FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386413118> ?p ?o ?g. }

• W4386413118 abstract "Summary Patients with multiple myeloma (MM) with chromosome 1q21 Gain (1q21+) are clinically and biologically heterogeneous. 1q21+ in the real world actually reflects the prognosis for gain/amplification of the CKS1B gene. In this study, we found that the copy number of prune exopolyphosphatase 1 ( PRUNE1 ), located on chromosome 1q21.3, could further stratify the prognosis of MM patients with 1q21+. Using selected reaction monitoring/multiple reaction monitoring (SRM/MRM) analysis, liquid chromatography–tandem mass spectrometry (LC–MS/MS), transmission electron microscopy (TEM), confocal fluorescence microscopy, calculation of adenosine triphosphate (ATP), intracellular reactive oxygen species (ROS) and mitochondrial oxygen consumption rates (OCRs), we demonstrated for the first time that PRUNE1 promotes the proliferation and invasion of MM cells by stimulating purine metabolism, purine synthesis enzymes and mitochondrial functions, enhancing links between purinosomes and mitochondria. SOX11 was identified as a transcription factor for PRUNE1. Through integrated analysis of the transcriptome and proteome, CD73 was determined to be the downstream target of PRUNE1. Furthermore, it has been determined that dipyridamole can effectively suppress the proliferation of MM cells with high‐expression levels of PRUNE1 in vitro and in vivo. These findings provide insights into disease‐causing mechanisms and new therapeutic targets for MM patients with 1q21+." @default.
• W4386413118 created "2023-09-05" @default.
• W4386413118 creator A5006627880 @default.
• W4386413118 creator A5006945645 @default.
• W4386413118 creator A5013535187 @default.
• W4386413118 creator A5030109415 @default.
• W4386413118 creator A5033323312 @default.
• W4386413118 creator A5067030467 @default.
• W4386413118 creator A5074628946 @default.
• W4386413118 date "2023-09-04" @default.
• W4386413118 modified "2023-09-30" @default.
• W4386413118 title "<scp>PRUNE1</scp> (located on chromosome 1q21.3) promotes multiple myeloma with 1q21 Gain by enhancing the links between purine and mitochondrion" @default.
• W4386413118 cites W1498172398 @default.
• W4386413118 cites W1922027332 @default.
• W4386413118 cites W2029436635 @default.
• W4386413118 cites W2041495660 @default.
• W4386413118 cites W2045010580 @default.
• W4386413118 cites W2051628879 @default.
• W4386413118 cites W2052773894 @default.
• W4386413118 cites W2064759291 @default.
• W4386413118 cites W2079282988 @default.
• W4386413118 cites W2089902119 @default.
• W4386413118 cites W2102278945 @default.
• W4386413118 cites W2115385885 @default.
• W4386413118 cites W2117692326 @default.
• W4386413118 cites W2124510143 @default.
• W4386413118 cites W2131271579 @default.
• W4386413118 cites W2138773756 @default.
• W4386413118 cites W2141458291 @default.
• W4386413118 cites W2141550675 @default.
• W4386413118 cites W2170515647 @default.
• W4386413118 cites W2486629951 @default.
• W4386413118 cites W2520654044 @default.
• W4386413118 cites W2593643692 @default.
• W4386413118 cites W2606401421 @default.
• W4386413118 cites W2616922646 @default.
• W4386413118 cites W2729371963 @default.
• W4386413118 cites W2758252083 @default.
• W4386413118 cites W2770323050 @default.
• W4386413118 cites W2793340326 @default.
• W4386413118 cites W2794480084 @default.
• W4386413118 cites W2799981419 @default.
• W4386413118 cites W2806376838 @default.
• W4386413118 cites W2890725238 @default.
• W4386413118 cites W2902338486 @default.
• W4386413118 cites W2904395643 @default.
• W4386413118 cites W2913434193 @default.
• W4386413118 cites W2913462228 @default.
• W4386413118 cites W2995383503 @default.
• W4386413118 cites W3033262554 @default.
• W4386413118 cites W3036192742 @default.
• W4386413118 cites W3042751689 @default.
• W4386413118 cites W3044926932 @default.
• W4386413118 cites W3166260715 @default.
• W4386413118 cites W3182706539 @default.
• W4386413118 cites W3204564031 @default.
• W4386413118 cites W4205976679 @default.
• W4386413118 cites W4221093336 @default.
• W4386413118 cites W4283361572 @default.
• W4386413118 cites W4293572476 @default.
• W4386413118 cites W4307628875 @default.
• W4386413118 cites W4310078340 @default.
• W4386413118 cites W4310598099 @default.
• W4386413118 cites W4312122495 @default.
• W4386413118 cites W4318214593 @default.
• W4386413118 doi "https://doi.org/10.1111/bjh.19088" @default.
• W4386413118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37666675" @default.
• W4386413118 hasPublicationYear "2023" @default.
• W4386413118 type Work @default.
• W4386413118 citedByCount "0" @default.
• W4386413118 crossrefType "journal-article" @default.
• W4386413118 hasAuthorship W4386413118A5006627880 @default.
• W4386413118 hasAuthorship W4386413118A5006945645 @default.
• W4386413118 hasAuthorship W4386413118A5013535187 @default.
• W4386413118 hasAuthorship W4386413118A5030109415 @default.
• W4386413118 hasAuthorship W4386413118A5033323312 @default.
• W4386413118 hasAuthorship W4386413118A5067030467 @default.
• W4386413118 hasAuthorship W4386413118A5074628946 @default.
• W4386413118 hasBestOaLocation W43864131181 @default.
• W4386413118 hasConcept C104317684 @default.
• W4386413118 hasConcept C150194340 @default.
• W4386413118 hasConcept C153911025 @default.
• W4386413118 hasConcept C162317418 @default.
• W4386413118 hasConcept C169586020 @default.
• W4386413118 hasConcept C181199279 @default.
• W4386413118 hasConcept C185592680 @default.
• W4386413118 hasConcept C2776476023 @default.
• W4386413118 hasConcept C28859421 @default.
• W4386413118 hasConcept C55493867 @default.
• W4386413118 hasConcept C86803240 @default.
• W4386413118 hasConcept C95444343 @default.
• W4386413118 hasConceptScore W4386413118C104317684 @default.
• W4386413118 hasConceptScore W4386413118C150194340 @default.
• W4386413118 hasConceptScore W4386413118C153911025 @default.
• W4386413118 hasConceptScore W4386413118C162317418 @default.
• W4386413118 hasConceptScore W4386413118C169586020 @default.
• W4386413118 hasConceptScore W4386413118C181199279 @default.
• W4386413118 hasConceptScore W4386413118C185592680 @default.
• W4386413118 hasConceptScore W4386413118C2776476023 @default.
• W4386413118 hasConceptScore W4386413118C28859421 @default.

• next