FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386413481> ?p ?o ?g. }

• W4386413481 endingPage "166878" @default.
• W4386413481 startingPage "166878" @default.
• W4386413481 abstract "Macrophage-driven chronic low-grade inflammatory response is intimately associated with pathogenesis of insulin resistance and type 2 diabetes (T2D). However, the molecular basis for skewing of pro-inflammatory macrophage is still elusive. Here, we describe the mechanism and significance of TGS1/PIMT (PRIP-Interacting protein with Methyl Transferase domain) in regulating macrophage activation and polarization and its impact on the development of insulin resistance in skeletal muscle cells. We show altered expression of TGS1 in M1 polarized cultured macrophages, bone marrow-derived (BMDM) and adipose tissue macrophages. Moreover, in High Fat Diet (HFD)-fed mice enhanced TGS1 expression is predominantly localized to the nucleus of adipose tissue macrophages suggesting its potential functional role. Gain and loss of TGS1 expression in macrophage further established its role in the secretion of pro-inflammatory mediators. Mechanistically, TGS1 controls the transcription of numerous genes linked to inflammation by forming a complex with Histone Acetyl Transferase (HAT)-containing transcriptional co-activators CBP and p300. Functionally, TGS1 mediated macrophage inflammatory response induces the development of insulin resistance in skeletal muscle cells and adipocytes. Our findings thus demonstrate an unexpected contribution of TGS1 in the regulation of macrophage mediated inflammation and insulin resistance highlighting that TGS1 antagonism could be a promising therapeutic target for the management of inflammation and insulin resistance in T2D." @default.
• W4386413481 created "2023-09-05" @default.
• W4386413481 creator A5011640671 @default.
• W4386413481 creator A5013248527 @default.
• W4386413481 creator A5023371410 @default.
• W4386413481 creator A5039843096 @default.
• W4386413481 creator A5058627249 @default.
• W4386413481 creator A5076206728 @default.
• W4386413481 creator A5092823152 @default.
• W4386413481 date "2024-01-01" @default.
• W4386413481 modified "2023-10-01" @default.
• W4386413481 title "TGS1/PIMT regulates pro-inflammatory macrophage mediated paracrine insulin resistance: Crosstalk between macrophages and skeletal muscle cells" @default.
• W4386413481 cites W1499902555 @default.
• W4386413481 cites W1629317989 @default.
• W4386413481 cites W1814898443 @default.
• W4386413481 cites W1964041401 @default.
• W4386413481 cites W1970559071 @default.
• W4386413481 cites W1974033843 @default.
• W4386413481 cites W1984230217 @default.
• W4386413481 cites W2030865745 @default.
• W4386413481 cites W2042683090 @default.
• W4386413481 cites W2054472394 @default.
• W4386413481 cites W2063131576 @default.
• W4386413481 cites W2072668724 @default.
• W4386413481 cites W2079688329 @default.
• W4386413481 cites W2088133087 @default.
• W4386413481 cites W2101328621 @default.
• W4386413481 cites W2120528492 @default.
• W4386413481 cites W2121817596 @default.
• W4386413481 cites W2129316761 @default.
• W4386413481 cites W2145697808 @default.
• W4386413481 cites W2159560463 @default.
• W4386413481 cites W2426939044 @default.
• W4386413481 cites W2589359615 @default.
• W4386413481 cites W2596378672 @default.
• W4386413481 cites W2606396227 @default.
• W4386413481 cites W2792246690 @default.
• W4386413481 cites W2993908729 @default.
• W4386413481 cites W3015496674 @default.
• W4386413481 cites W3111400727 @default.
• W4386413481 cites W4207075716 @default.
• W4386413481 cites W4238497443 @default.
• W4386413481 cites W4249727000 @default.
• W4386413481 cites W4306385315 @default.
• W4386413481 cites W4318953565 @default.
• W4386413481 cites W4367625097 @default.
• W4386413481 doi "https://doi.org/10.1016/j.bbadis.2023.166878" @default.
• W4386413481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37673359" @default.
• W4386413481 hasPublicationYear "2024" @default.
• W4386413481 type Work @default.
• W4386413481 citedByCount "1" @default.
• W4386413481 countsByYear W43864134812023 @default.
• W4386413481 crossrefType "journal-article" @default.
• W4386413481 hasAuthorship W4386413481A5011640671 @default.
• W4386413481 hasAuthorship W4386413481A5013248527 @default.
• W4386413481 hasAuthorship W4386413481A5023371410 @default.
• W4386413481 hasAuthorship W4386413481A5039843096 @default.
• W4386413481 hasAuthorship W4386413481A5058627249 @default.
• W4386413481 hasAuthorship W4386413481A5076206728 @default.
• W4386413481 hasAuthorship W4386413481A5092823152 @default.
• W4386413481 hasConcept C120665830 @default.
• W4386413481 hasConcept C121332964 @default.
• W4386413481 hasConcept C126322002 @default.
• W4386413481 hasConcept C134018914 @default.
• W4386413481 hasConcept C169822122 @default.
• W4386413481 hasConcept C170493617 @default.
• W4386413481 hasConcept C171089720 @default.
• W4386413481 hasConcept C17675752 @default.
• W4386413481 hasConcept C202751555 @default.
• W4386413481 hasConcept C203014093 @default.
• W4386413481 hasConcept C2776682551 @default.
• W4386413481 hasConcept C2776914184 @default.
• W4386413481 hasConcept C2777391703 @default.
• W4386413481 hasConcept C2779244956 @default.
• W4386413481 hasConcept C2779306644 @default.
• W4386413481 hasConcept C2910375186 @default.
• W4386413481 hasConcept C55493867 @default.
• W4386413481 hasConcept C71924100 @default.
• W4386413481 hasConcept C7876069 @default.
• W4386413481 hasConcept C86803240 @default.
• W4386413481 hasConcept C95444343 @default.
• W4386413481 hasConceptScore W4386413481C120665830 @default.
• W4386413481 hasConceptScore W4386413481C121332964 @default.
• W4386413481 hasConceptScore W4386413481C126322002 @default.
• W4386413481 hasConceptScore W4386413481C134018914 @default.
• W4386413481 hasConceptScore W4386413481C169822122 @default.
• W4386413481 hasConceptScore W4386413481C170493617 @default.
• W4386413481 hasConceptScore W4386413481C171089720 @default.
• W4386413481 hasConceptScore W4386413481C17675752 @default.
• W4386413481 hasConceptScore W4386413481C202751555 @default.
• W4386413481 hasConceptScore W4386413481C203014093 @default.
• W4386413481 hasConceptScore W4386413481C2776682551 @default.
• W4386413481 hasConceptScore W4386413481C2776914184 @default.
• W4386413481 hasConceptScore W4386413481C2777391703 @default.
• W4386413481 hasConceptScore W4386413481C2779244956 @default.
• W4386413481 hasConceptScore W4386413481C2779306644 @default.
• W4386413481 hasConceptScore W4386413481C2910375186 @default.
• W4386413481 hasConceptScore W4386413481C55493867 @default.

• next