FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386415343> ?p ?o ?g. }

• W4386415343 abstract "Abstract We examined the individual prognostic contribution of absolute neutrophil (ANC), lymphocyte (ALC), and monocyte (AMC) counts, on overall (OS), leukemia‐free (LFS), and myelofibrosis‐free (MFFS) survival in essential thrombocythemia (ET). Informative cases ( N = 598; median age 59 years; females 62%) were retrospectively accrued from a Mayo Clinic database: JAK2 59%, CALR 27%, triple‐negative 11%, and MPL 3%; international prognostic scoring system for ET (IPSET) risk high 21%, intermediate 42%, and low 37%; 7% (37/515) had abnormal karyotype and 10% (21/205) adverse mutations ( SF3B1/SRSF2/U2AF1/TP53 ). At median 8.4 years, 163 (27%) deaths, 71 (12%) fibrotic, and 20 (3%) leukemic transformations were recorded. Multivariable analysis resulted in HR (95% CI) of 16.5 (9.9–27.4) for age > 70 years, 3.7 (2.3–6.0) for age 50–70 years, 2.4 (1.7–3.3) for ANC ≥8 × 10 9 /L, and 1.9 (1.4–2.6) for ALC <1.7 × 10 9 /L. The corresponding HR‐based scores were 4, 2, 1, and 1, resulting in an new 4‐tiered AgeAncAlc (AAA; triple A) risk model: high (5–6 points; median survival 8 years; HR 30.1, 95% CI 17.6–54), intermediate‐2 (4 points; median 13.5 years; HR 12.7, 95% CI 7.1–23.0), intermediate‐1 (2–3 points; median 20.7 years; HR 3.8, 95% CI 2.3–6.4) and low (0–1 points; median 47 years). The AAA model (Akaike Information Criterion [AIC] 621) performed better than IPSET (AIC 647) and was subsequently validated by an external University of Florence ET cohort ( N = 485). None of the AAA variables predicted LFS while ALC <1.7 × 10 9 /L was associated with inferior MFFS ( p = .01). Adverse mutations ( p < .01) and karyotype ( p < .01) displayed additional prognostic value without disqualifying the prognostic integrity of the AAA model. This study proposes a simple and globally applicable survival model for ET, which can be used as a platform for further molecular refinement. This study also suggests a potential role for immune‐related biomarkers, as a prognostic tool in myeloproliferative neoplasms." @default.
• W4386415343 created "2023-09-05" @default.
• W4386415343 creator A5002643270 @default.
• W4386415343 creator A5008437556 @default.
• W4386415343 creator A5013539196 @default.
• W4386415343 creator A5014707543 @default.
• W4386415343 creator A5016216479 @default.
• W4386415343 creator A5019229900 @default.
• W4386415343 creator A5024612499 @default.
• W4386415343 creator A5032323700 @default.
• W4386415343 creator A5046772202 @default.
• W4386415343 creator A5053174640 @default.
• W4386415343 creator A5054304877 @default.
• W4386415343 creator A5061275603 @default.
• W4386415343 creator A5069072959 @default.
• W4386415343 creator A5073001728 @default.
• W4386415343 date "2023-09-04" @default.
• W4386415343 modified "2023-10-16" @default.
• W4386415343 title "A globally applicable “triple <scp>A</scp>” risk model for essential thrombocythemia based on <scp>A</scp>ge, <scp>A</scp>bsolute neutrophil count, and <scp>A</scp>bsolute lymphocyte count" @default.
• W4386415343 cites W1757492577 @default.
• W4386415343 cites W1967491538 @default.
• W4386415343 cites W1977342027 @default.
• W4386415343 cites W1980724348 @default.
• W4386415343 cites W1985994644 @default.
• W4386415343 cites W2009825752 @default.
• W4386415343 cites W2030356048 @default.
• W4386415343 cites W2030868349 @default.
• W4386415343 cites W2072881492 @default.
• W4386415343 cites W2075485826 @default.
• W4386415343 cites W2079939446 @default.
• W4386415343 cites W2111141291 @default.
• W4386415343 cites W2148237316 @default.
• W4386415343 cites W2339658711 @default.
• W4386415343 cites W2597513205 @default.
• W4386415343 cites W2775539199 @default.
• W4386415343 cites W2790425028 @default.
• W4386415343 cites W2889194299 @default.
• W4386415343 cites W2917495513 @default.
• W4386415343 cites W2968465690 @default.
• W4386415343 cites W2989650549 @default.
• W4386415343 cites W3000101033 @default.
• W4386415343 cites W3120602004 @default.
• W4386415343 cites W3214822775 @default.
• W4386415343 cites W4200233511 @default.
• W4386415343 cites W4211088843 @default.
• W4386415343 cites W4253724263 @default.
• W4386415343 cites W4283716970 @default.
• W4386415343 cites W4302286359 @default.
• W4386415343 cites W4313498987 @default.
• W4386415343 cites W4321004177 @default.
• W4386415343 doi "https://doi.org/10.1002/ajh.27079" @default.
• W4386415343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37665758" @default.
• W4386415343 hasPublicationYear "2023" @default.
• W4386415343 type Work @default.
• W4386415343 citedByCount "0" @default.
• W4386415343 crossrefType "journal-article" @default.
• W4386415343 hasAuthorship W4386415343A5002643270 @default.
• W4386415343 hasAuthorship W4386415343A5008437556 @default.
• W4386415343 hasAuthorship W4386415343A5013539196 @default.
• W4386415343 hasAuthorship W4386415343A5014707543 @default.
• W4386415343 hasAuthorship W4386415343A5016216479 @default.
• W4386415343 hasAuthorship W4386415343A5019229900 @default.
• W4386415343 hasAuthorship W4386415343A5024612499 @default.
• W4386415343 hasAuthorship W4386415343A5032323700 @default.
• W4386415343 hasAuthorship W4386415343A5046772202 @default.
• W4386415343 hasAuthorship W4386415343A5053174640 @default.
• W4386415343 hasAuthorship W4386415343A5054304877 @default.
• W4386415343 hasAuthorship W4386415343A5061275603 @default.
• W4386415343 hasAuthorship W4386415343A5069072959 @default.
• W4386415343 hasAuthorship W4386415343A5073001728 @default.
• W4386415343 hasBestOaLocation W43864153431 @default.
• W4386415343 hasConcept C126322002 @default.
• W4386415343 hasConcept C203014093 @default.
• W4386415343 hasConcept C2777063308 @default.
• W4386415343 hasConcept C2777761686 @default.
• W4386415343 hasConcept C2780007613 @default.
• W4386415343 hasConcept C2780076729 @default.
• W4386415343 hasConcept C2780240888 @default.
• W4386415343 hasConcept C2780817109 @default.
• W4386415343 hasConcept C2781057849 @default.
• W4386415343 hasConcept C29730261 @default.
• W4386415343 hasConcept C71924100 @default.
• W4386415343 hasConcept C74133956 @default.
• W4386415343 hasConcept C89560881 @default.
• W4386415343 hasConcept C90924648 @default.
• W4386415343 hasConceptScore W4386415343C126322002 @default.
• W4386415343 hasConceptScore W4386415343C203014093 @default.
• W4386415343 hasConceptScore W4386415343C2777063308 @default.
• W4386415343 hasConceptScore W4386415343C2777761686 @default.
• W4386415343 hasConceptScore W4386415343C2780007613 @default.
• W4386415343 hasConceptScore W4386415343C2780076729 @default.
• W4386415343 hasConceptScore W4386415343C2780240888 @default.
• W4386415343 hasConceptScore W4386415343C2780817109 @default.
• W4386415343 hasConceptScore W4386415343C2781057849 @default.
• W4386415343 hasConceptScore W4386415343C29730261 @default.
• W4386415343 hasConceptScore W4386415343C71924100 @default.
• W4386415343 hasConceptScore W4386415343C74133956 @default.
• W4386415343 hasConceptScore W4386415343C89560881 @default.
• W4386415343 hasConceptScore W4386415343C90924648 @default.
• W4386415343 hasFunder F4320323054 @default.

• next