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• W4386418754 abstract "ABSTRACT Vancomycin intermediate-resistant Staphylococcus aureus (VISA) is a pathogen of concern. VraS, a histidine kinase, facilitates the VISA phenotype. Here, we reveal a benzoxazolylurea that directly inhibits VraS and enhances vancomycin to below the clinical breakpoint against an archetypal VISA strain. To the best of our knowledge, this is the first direct VraS inhibitor ever reported that shows significant enhancement of vancomycin against VISA." @default.
• W4386418754 created "2023-09-05" @default.
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• W4386418754 date "2023-09-03" @default.
• W4386418754 modified "2023-09-27" @default.
• W4386418754 title "A benzoxazolylurea inhibits VraS and enhances antimicrobials against vancomycin intermediate-resistant Staphylococcus aureus" @default.
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• W4386418754 doi "https://doi.org/10.1101/2023.08.31.555806" @default.
• W4386418754 hasPublicationYear "2023" @default.
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