Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386419314> ?p ?o ?g. }
- W4386419314 abstract "ABSTRACT The spherical bacterium Staphylococcus aureus , a leading cause of nosocomial infections, undergoes binary fission by dividing in two alternating orthogonal planes, but the mechanism by which S. aureus correctly selects the next cell division plane is not known. To identify cell division placement factors, we performed a chemical genetic screen that revealed a gene which we termed pcdA . We show that PcdA is a member of the McrB family of AAA+ NTPases that has undergone structural changes and a concomitant functional shift from a restriction enzyme subunit to an early cell division protein. PcdA directly interacts with the tubulin-like central divisome component FtsZ and localizes to future cell division sites before membrane invagination initiates. This parallels the action of another McrB family protein, CTTNBP2, which stabilizes microtubules in animals. We show that PcdA also interacts with the structural protein DivIVA and propose that the DivIVA/PcdA complex recruits unpolymerized FtsZ to assemble along the proper cell division plane. Deletion of pcdA conferred abnormal, non-orthogonal division plane selection, increased sensitivity to cell wall-targeting antibiotics, and reduced virulence in a murine infection model. Targeting PcdA could therefore highlight a treatment strategy for combatting antibiotic-resistant strains of S. aureus ." @default.
- W4386419314 created "2023-09-05" @default.
- W4386419314 creator A5005368537 @default.
- W4386419314 creator A5009208815 @default.
- W4386419314 creator A5024629664 @default.
- W4386419314 creator A5026932356 @default.
- W4386419314 creator A5059079968 @default.
- W4386419314 creator A5061543166 @default.
- W4386419314 creator A5066053482 @default.
- W4386419314 creator A5071305391 @default.
- W4386419314 creator A5076748687 @default.
- W4386419314 creator A5088275965 @default.
- W4386419314 date "2023-09-03" @default.
- W4386419314 modified "2023-09-29" @default.
- W4386419314 title "Protein coopted from a phage restriction system dictates orthogonal cell division plane selection in Staphylococcus aureus" @default.
- W4386419314 cites W1512049313 @default.
- W4386419314 cites W1800014854 @default.
- W4386419314 cites W1865825039 @default.
- W4386419314 cites W1901667800 @default.
- W4386419314 cites W1961464713 @default.
- W4386419314 cites W1969003508 @default.
- W4386419314 cites W1975256163 @default.
- W4386419314 cites W1981138564 @default.
- W4386419314 cites W1986181072 @default.
- W4386419314 cites W1996029720 @default.
- W4386419314 cites W2001277616 @default.
- W4386419314 cites W2001652739 @default.
- W4386419314 cites W2021312899 @default.
- W4386419314 cites W2026220836 @default.
- W4386419314 cites W2027466240 @default.
- W4386419314 cites W2028904598 @default.
- W4386419314 cites W2046708334 @default.
- W4386419314 cites W2047670590 @default.
- W4386419314 cites W2049431015 @default.
- W4386419314 cites W2059081233 @default.
- W4386419314 cites W2082667898 @default.
- W4386419314 cites W2093661624 @default.
- W4386419314 cites W2106941304 @default.
- W4386419314 cites W2110743190 @default.
- W4386419314 cites W2123378429 @default.
- W4386419314 cites W2127113854 @default.
- W4386419314 cites W2132629607 @default.
- W4386419314 cites W2145268834 @default.
- W4386419314 cites W2145546429 @default.
- W4386419314 cites W2149055528 @default.
- W4386419314 cites W2152783224 @default.
- W4386419314 cites W2153374357 @default.
- W4386419314 cites W2163846478 @default.
- W4386419314 cites W2167370287 @default.
- W4386419314 cites W2270731344 @default.
- W4386419314 cites W2600936327 @default.
- W4386419314 cites W2613142165 @default.
- W4386419314 cites W2613570472 @default.
- W4386419314 cites W2727035568 @default.
- W4386419314 cites W2737196618 @default.
- W4386419314 cites W2737279591 @default.
- W4386419314 cites W2747808744 @default.
- W4386419314 cites W2751583588 @default.
- W4386419314 cites W2895198460 @default.
- W4386419314 cites W2930049421 @default.
- W4386419314 cites W2951904782 @default.
- W4386419314 cites W2959440892 @default.
- W4386419314 cites W2967544277 @default.
- W4386419314 cites W2996647957 @default.
- W4386419314 cites W3003509394 @default.
- W4386419314 cites W3015586265 @default.
- W4386419314 cites W3049658440 @default.
- W4386419314 cites W3101667854 @default.
- W4386419314 cites W3104438892 @default.
- W4386419314 cites W3108271252 @default.
- W4386419314 cites W3159719254 @default.
- W4386419314 cites W3164683859 @default.
- W4386419314 cites W3177828909 @default.
- W4386419314 cites W3202105508 @default.
- W4386419314 cites W4210613466 @default.
- W4386419314 cites W4237465007 @default.
- W4386419314 cites W4240297670 @default.
- W4386419314 cites W4366990620 @default.
- W4386419314 doi "https://doi.org/10.1101/2023.09.03.556088" @default.
- W4386419314 hasPublicationYear "2023" @default.
- W4386419314 type Work @default.
- W4386419314 citedByCount "0" @default.
- W4386419314 crossrefType "posted-content" @default.
- W4386419314 hasAuthorship W4386419314A5005368537 @default.
- W4386419314 hasAuthorship W4386419314A5009208815 @default.
- W4386419314 hasAuthorship W4386419314A5024629664 @default.
- W4386419314 hasAuthorship W4386419314A5026932356 @default.
- W4386419314 hasAuthorship W4386419314A5059079968 @default.
- W4386419314 hasAuthorship W4386419314A5061543166 @default.
- W4386419314 hasAuthorship W4386419314A5066053482 @default.
- W4386419314 hasAuthorship W4386419314A5071305391 @default.
- W4386419314 hasAuthorship W4386419314A5076748687 @default.
- W4386419314 hasAuthorship W4386419314A5088275965 @default.
- W4386419314 hasBestOaLocation W43864193141 @default.
- W4386419314 hasConcept C104317684 @default.
- W4386419314 hasConcept C1491633281 @default.
- W4386419314 hasConcept C2776237524 @default.
- W4386419314 hasConcept C2779489039 @default.
- W4386419314 hasConcept C523546767 @default.
- W4386419314 hasConcept C54355233 @default.