Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386421547> ?p ?o ?g. }
- W4386421547 abstract "Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic disorder characterized by pelvic and/or bladder pain, along with lower urinary tract symptoms that have a significant impact on an individual’s quality of life. The diverse range of symptoms and underlying causes in IC/BPS patients pose a significant challenge for effective disease management and the development of new and effective treatments. To facilitate the development of innovative therapies for IC/BPS, numerous preclinical animal models have been developed, each focusing on distinct pathophysiological components such as localized urothelial permeability or inflammation, psychological stress, autoimmunity, and central sensitization. However, since the precise etiopathophysiology of IC/BPS remains undefined, these animal models have primarily aimed to replicate the key clinical symptoms of bladder hypersensitivity and pain to enhance the translatability of potential therapeutics. Several animal models have now been characterized to mimic the major symptoms of IC/BPS, and significant progress has been made in refining these models to induce chronic symptomatology that more closely resembles the IC/BPS phenotype. Nevertheless, it's important to note that no single model can fully replicate all aspects of the human disease. When selecting an appropriate model for preclinical therapeutic evaluation, consideration must be given to the specific pathology believed to underlie the development of IC/BPS symptoms in a particular patient group, as well as the type and severity of the model, its duration, and the proposed intervention’s mechanism of action. Therefore, it is likely that different models will continue to be necessary for preclinical drug development, depending on the unique etiology of IC/BPS being investigated." @default.
- W4386421547 created "2023-09-05" @default.
- W4386421547 creator A5054558614 @default.
- W4386421547 creator A5076728319 @default.
- W4386421547 date "2023-09-04" @default.
- W4386421547 modified "2023-09-28" @default.
- W4386421547 title "Animal models of interstitial cystitis/bladder pain syndrome" @default.
- W4386421547 cites W108337335 @default.
- W4386421547 cites W146409794 @default.
- W4386421547 cites W1502228150 @default.
- W4386421547 cites W1502836460 @default.
- W4386421547 cites W1503571030 @default.
- W4386421547 cites W1514553982 @default.
- W4386421547 cites W1536174640 @default.
- W4386421547 cites W1561891673 @default.
- W4386421547 cites W1578911538 @default.
- W4386421547 cites W1579133082 @default.
- W4386421547 cites W1580207267 @default.
- W4386421547 cites W1586846969 @default.
- W4386421547 cites W1590044823 @default.
- W4386421547 cites W1592153121 @default.
- W4386421547 cites W1607913602 @default.
- W4386421547 cites W1612465238 @default.
- W4386421547 cites W1640645158 @default.
- W4386421547 cites W1827370309 @default.
- W4386421547 cites W1831458736 @default.
- W4386421547 cites W183249409 @default.
- W4386421547 cites W1855850047 @default.
- W4386421547 cites W186740274 @default.
- W4386421547 cites W1872463428 @default.
- W4386421547 cites W1903377085 @default.
- W4386421547 cites W1963566296 @default.
- W4386421547 cites W1965066347 @default.
- W4386421547 cites W1966134861 @default.
- W4386421547 cites W1967130254 @default.
- W4386421547 cites W1968858550 @default.
- W4386421547 cites W1970050155 @default.
- W4386421547 cites W1970698916 @default.
- W4386421547 cites W1971161131 @default.
- W4386421547 cites W1972262223 @default.
- W4386421547 cites W1973247479 @default.
- W4386421547 cites W1976177602 @default.
- W4386421547 cites W1980721328 @default.
- W4386421547 cites W1981310378 @default.
- W4386421547 cites W1985548667 @default.
- W4386421547 cites W1985743386 @default.
- W4386421547 cites W1986241226 @default.
- W4386421547 cites W1988119950 @default.
- W4386421547 cites W1997246218 @default.
- W4386421547 cites W2006295537 @default.
- W4386421547 cites W2008616142 @default.
- W4386421547 cites W2008969125 @default.
- W4386421547 cites W2013942626 @default.
- W4386421547 cites W2015287365 @default.
- W4386421547 cites W2016473780 @default.
- W4386421547 cites W2016941468 @default.
- W4386421547 cites W2018577706 @default.
- W4386421547 cites W2018745308 @default.
- W4386421547 cites W2022375467 @default.
- W4386421547 cites W2023934341 @default.
- W4386421547 cites W2024893751 @default.
- W4386421547 cites W2025448962 @default.
- W4386421547 cites W2026634713 @default.
- W4386421547 cites W2029433444 @default.
- W4386421547 cites W2029537685 @default.
- W4386421547 cites W2029719395 @default.
- W4386421547 cites W2029986303 @default.
- W4386421547 cites W2030829370 @default.
- W4386421547 cites W2033847052 @default.
- W4386421547 cites W2035679857 @default.
- W4386421547 cites W2036156711 @default.
- W4386421547 cites W2036500600 @default.
- W4386421547 cites W2036875650 @default.
- W4386421547 cites W2041591721 @default.
- W4386421547 cites W2046960533 @default.
- W4386421547 cites W2048025784 @default.
- W4386421547 cites W2052800581 @default.
- W4386421547 cites W2054146357 @default.
- W4386421547 cites W2054255246 @default.
- W4386421547 cites W2055408622 @default.
- W4386421547 cites W2060674460 @default.
- W4386421547 cites W2060948456 @default.
- W4386421547 cites W2063308564 @default.
- W4386421547 cites W2063928696 @default.
- W4386421547 cites W2066320273 @default.
- W4386421547 cites W2066404757 @default.
- W4386421547 cites W2066631607 @default.
- W4386421547 cites W2069137464 @default.
- W4386421547 cites W2069700592 @default.
- W4386421547 cites W2075997480 @default.
- W4386421547 cites W2076357012 @default.
- W4386421547 cites W2082219200 @default.
- W4386421547 cites W2083608576 @default.
- W4386421547 cites W2085428036 @default.
- W4386421547 cites W2086105638 @default.
- W4386421547 cites W2088080391 @default.
- W4386421547 cites W2091290992 @default.
- W4386421547 cites W2093629630 @default.
- W4386421547 cites W2097117109 @default.
- W4386421547 cites W2097247989 @default.