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- W4386424322 endingPage "126697" @default.
- W4386424322 startingPage "126697" @default.
- W4386424322 abstract "Wound healing is a multifaceted and complex process that includes inflammation, hemostasis, remodeling, and granulation. Failures in any link may cause the healing process to be delayed. As a result, wound healing has always been a main research focus across the entire medical field, posing significant challenges and financial burdens. Hence, the current investigation focused on the design and development of arginine-modified chitosan/PVA hydrogel-based microneedles (MNs) as a curcumin (CUR) delivery system for improved wound healing and antibacterial activity. The substrate possesses exceptional swelling capabilities that allow tissue fluid from the wound to be absorbed, speeding up wound closure. The antibacterial activity of MNs was investigated against S. aureus and E. coli. The results revealed that the developed CUR-loaded MNs had increased antioxidant activity and sustained drug release behavior. Furthermore, after being loaded in the developed MNs, it revealed improved antibacterial activity of CUR. Wound healing potential was assessed by histopathological analysis and wound closure%. The observed results suggest that the CUR-loaded MNs greatly improved wound healing potential via tissue regeneration and collagen deposition, demonstrating the potential of developed MNs patches to be used as an effective carrier for wound healing in healthcare settings." @default.
- W4386424322 created "2023-09-05" @default.
- W4386424322 creator A5017049737 @default.
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- W4386424322 creator A5091775788 @default.
- W4386424322 date "2023-12-01" @default.
- W4386424322 modified "2023-09-26" @default.
- W4386424322 title "Microarray needles comprised of arginine-modified chitosan/PVA hydrogel for enhanced antibacterial and wound healing potential of curcumin" @default.
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- W4386424322 doi "https://doi.org/10.1016/j.ijbiomac.2023.126697" @default.