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- W4386424532 endingPage "102062" @default.
- W4386424532 startingPage "102062" @default.
- W4386424532 abstract "Environmental and occupational exposure to hazardous substances accelerates biological aging. However, the toxic effects of nanomaterials on telomere and cellular senescence (major hallmarks of the biological aging) remained controversial. This study was to synthesize all published evidence to explore the effects of nanomaterial exposure on the telomere change, cellular senescence and mortality of model animals. Thirty-five studies were included by searching electronic databases (PubMed, Embase and Web of Science). The pooled analysis by Stata 15.0 software showed that compared with the control, nanomaterial exposure could significantly shorten the telomere length [measured as kbp: standardized mean difference (SMD) = -1.88; 95% confidence interval (CI) = -3.13 – -0.64; % of control: SMD = -1.26; 95%CI = -2.11– -0.42; < 3 kbp %: SMD = 5.76; 95%CI = 2.92 – 8.60), increase the telomerase activity (SMD = -1.00; 95%CI = -1.74 – -0.26), senescence-associated β-galactosidase levels in cells (SMD = 8.20; 95%CI = 6.05 – 10.34) and zebrafish embryos (SMD = 7.32; 95%CI = 4.70 – 9.94) as well as the mortality of zebrafish (SMD = 3.83; 95%CI = 2.94 – 4.72)]. The expression levels of telomerase TERT, shelterin components (TRF1, TRF2 and POT1) and senescence biomarkers (p21, p16) were respectively identified to be decreased or increased in subgroup analyses. In conclusion, this meta-analysis demonstrates that nanomaterial exposure is associated with telomere attrition, cell senescence and organismal death." @default.
- W4386424532 created "2023-09-05" @default.
- W4386424532 creator A5007834895 @default.
- W4386424532 creator A5010301775 @default.
- W4386424532 creator A5022802322 @default.
- W4386424532 creator A5037681415 @default.
- W4386424532 creator A5083404387 @default.
- W4386424532 date "2023-11-01" @default.
- W4386424532 modified "2023-09-27" @default.
- W4386424532 title "Effects of Nanomaterial Exposure on Telomere Dysfunction, Hallmarks of Mammalian and Zebrafish Cell Senescence, and Zebrafish Mortality" @default.
- W4386424532 cites W1590561480 @default.
- W4386424532 cites W1986808724 @default.
- W4386424532 cites W1996952541 @default.
- W4386424532 cites W1998747335 @default.
- W4386424532 cites W2001295032 @default.
- W4386424532 cites W2002255627 @default.
- W4386424532 cites W2003446723 @default.
- W4386424532 cites W2009357228 @default.
- W4386424532 cites W2013987722 @default.
- W4386424532 cites W2014437104 @default.
- W4386424532 cites W2024733002 @default.
- W4386424532 cites W2029456327 @default.
- W4386424532 cites W2032991822 @default.
- W4386424532 cites W2034761114 @default.
- W4386424532 cites W2036639619 @default.
- W4386424532 cites W2047860054 @default.
- W4386424532 cites W2058571677 @default.
- W4386424532 cites W2062395030 @default.
- W4386424532 cites W2075980277 @default.
- W4386424532 cites W2098312065 @default.
- W4386424532 cites W2110565388 @default.
- W4386424532 cites W2153461638 @default.
- W4386424532 cites W2157271021 @default.
- W4386424532 cites W2162057862 @default.
- W4386424532 cites W2165340198 @default.
- W4386424532 cites W2169309858 @default.
- W4386424532 cites W2170506418 @default.
- W4386424532 cites W2183678767 @default.
- W4386424532 cites W2285882574 @default.
- W4386424532 cites W2315682205 @default.
- W4386424532 cites W2316744180 @default.
- W4386424532 cites W2347193990 @default.
- W4386424532 cites W2465967941 @default.
- W4386424532 cites W2517591559 @default.
- W4386424532 cites W2577072214 @default.
- W4386424532 cites W2760601553 @default.
- W4386424532 cites W2763414868 @default.
- W4386424532 cites W2772143356 @default.
- W4386424532 cites W2808722214 @default.
- W4386424532 cites W2889963064 @default.
- W4386424532 cites W2896236665 @default.
- W4386424532 cites W2898136889 @default.
- W4386424532 cites W2901725075 @default.
- W4386424532 cites W2903075687 @default.
- W4386424532 cites W2906297534 @default.
- W4386424532 cites W2907531390 @default.
- W4386424532 cites W2911635622 @default.
- W4386424532 cites W2924502542 @default.
- W4386424532 cites W2947597328 @default.
- W4386424532 cites W2950192924 @default.
- W4386424532 cites W2963536788 @default.
- W4386424532 cites W2965342894 @default.
- W4386424532 cites W3004110216 @default.
- W4386424532 cites W3012383235 @default.
- W4386424532 cites W3013207020 @default.
- W4386424532 cites W3035392077 @default.
- W4386424532 cites W3042763112 @default.
- W4386424532 cites W3047426364 @default.
- W4386424532 cites W3048043984 @default.
- W4386424532 cites W3093938386 @default.
- W4386424532 cites W3108147177 @default.
- W4386424532 cites W3109324289 @default.
- W4386424532 cites W3112638854 @default.
- W4386424532 cites W3114155501 @default.
- W4386424532 cites W3121207180 @default.
- W4386424532 cites W3157869551 @default.
- W4386424532 cites W3158264986 @default.
- W4386424532 cites W3162089396 @default.
- W4386424532 cites W3164732278 @default.
- W4386424532 cites W3174007007 @default.
- W4386424532 cites W3180872259 @default.
- W4386424532 cites W3185162347 @default.
- W4386424532 cites W3192348719 @default.
- W4386424532 cites W3192626265 @default.
- W4386424532 cites W3193959016 @default.
- W4386424532 cites W3203796926 @default.
- W4386424532 cites W3205582645 @default.
- W4386424532 cites W3206663935 @default.
- W4386424532 cites W373873944 @default.
- W4386424532 cites W4200501792 @default.
- W4386424532 cites W4205930897 @default.
- W4386424532 cites W4206758580 @default.
- W4386424532 cites W4210720818 @default.
- W4386424532 cites W4210721493 @default.
- W4386424532 cites W4214776784 @default.
- W4386424532 cites W4223519766 @default.
- W4386424532 cites W4224030188 @default.
- W4386424532 cites W4224234800 @default.