FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386425318> ?p ?o ?g. }

• W4386425318 abstract "The majority of deaths from malaria are in young African children. Parenteral artesunate (ARS) is the first‐line treatment for severe falciparum malaria. Since 2015, the World Health Organization has recommended individual doses of 3 mg/kg for children weighing < 20 kg. Recently, the US Food and Drug Administration (FDA) has challenged this recommendation, based on a simulated pediatric population, and argued for a lower dose in younger children (2.4 mg/kg). In this study, we performed population pharmacokinetic (PK) modeling of plasma concentration data from 80 children with severe falciparum malaria in the Democratic Republic of Congo who were given 2.4 mg/kg of ARS intravenously. Bayesian hierarchical modeling and a two‐compartment parent drug‐metabolite PK model for ARS were used to describe the population PKs of ARS and its main biologically active metabolite dihydroartemisinin. We then generated a virtual population representative of the target population in which the drug is used and simulated the total first‐dose exposures. Our study shows that the majority of younger children given the lower 2.4 mg/kg dose of intravenous ARS do not reach the same drug exposures as older children above 20 kg. This finding supports withdrawal of the FDA's recent lower ARS dose recommendation as parenteral ARS is an extremely safe and well‐tolerated drug and there is potential for harm from underdosing in this rapidly lethal infection." @default.
• W4386425318 created "2023-09-05" @default.
• W4386425318 creator A5007135659 @default.
• W4386425318 creator A5008316351 @default.
• W4386425318 creator A5029054664 @default.
• W4386425318 creator A5055163004 @default.
• W4386425318 creator A5057569681 @default.
• W4386425318 creator A5084217335 @default.
• W4386425318 creator A5086476653 @default.
• W4386425318 creator A5090110810 @default.
• W4386425318 creator A5090299164 @default.
• W4386425318 creator A5090998567 @default.
• W4386425318 date "2023-09-15" @default.
• W4386425318 modified "2023-10-14" @default.
• W4386425318 title "Evidence based optimal dosing of intravenous artesunate in children with severe <i>falciparum</i> malaria" @default.
• W4386425318 cites W1518816458 @default.
• W4386425318 cites W1673362020 @default.
• W4386425318 cites W1965418384 @default.
• W4386425318 cites W1970564042 @default.
• W4386425318 cites W2014212853 @default.
• W4386425318 cites W2021538725 @default.
• W4386425318 cites W2039192863 @default.
• W4386425318 cites W2053346910 @default.
• W4386425318 cites W2084045976 @default.
• W4386425318 cites W2101112779 @default.
• W4386425318 cites W2104419634 @default.
• W4386425318 cites W2105028287 @default.
• W4386425318 cites W2110383454 @default.
• W4386425318 cites W2117590566 @default.
• W4386425318 cites W2123640851 @default.
• W4386425318 cites W2154482991 @default.
• W4386425318 cites W2162779994 @default.
• W4386425318 cites W2162842262 @default.
• W4386425318 cites W2234933177 @default.
• W4386425318 cites W2313139941 @default.
• W4386425318 cites W2320022633 @default.
• W4386425318 cites W2322213143 @default.
• W4386425318 cites W2410093489 @default.
• W4386425318 cites W2577537660 @default.
• W4386425318 cites W3127085032 @default.
• W4386425318 cites W3133022102 @default.
• W4386425318 cites W4205604162 @default.
• W4386425318 cites W4302293775 @default.
• W4386425318 doi "https://doi.org/10.1002/cpt.3041" @default.
• W4386425318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37666798" @default.
• W4386425318 hasPublicationYear "2023" @default.
• W4386425318 type Work @default.
• W4386425318 citedByCount "0" @default.
• W4386425318 crossrefType "journal-article" @default.
• W4386425318 hasAuthorship W4386425318A5007135659 @default.
• W4386425318 hasAuthorship W4386425318A5008316351 @default.
• W4386425318 hasAuthorship W4386425318A5029054664 @default.
• W4386425318 hasAuthorship W4386425318A5055163004 @default.
• W4386425318 hasAuthorship W4386425318A5057569681 @default.
• W4386425318 hasAuthorship W4386425318A5084217335 @default.
• W4386425318 hasAuthorship W4386425318A5086476653 @default.
• W4386425318 hasAuthorship W4386425318A5090110810 @default.
• W4386425318 hasAuthorship W4386425318A5090299164 @default.
• W4386425318 hasAuthorship W4386425318A5090998567 @default.
• W4386425318 hasBestOaLocation W43864253181 @default.
• W4386425318 hasConcept C112705442 @default.
• W4386425318 hasConcept C203014093 @default.
• W4386425318 hasConcept C2776120307 @default.
• W4386425318 hasConcept C2777288759 @default.
• W4386425318 hasConcept C2778048844 @default.
• W4386425318 hasConcept C2778059366 @default.
• W4386425318 hasConcept C2778371730 @default.
• W4386425318 hasConcept C2780035454 @default.
• W4386425318 hasConcept C2781160685 @default.
• W4386425318 hasConcept C2908647359 @default.
• W4386425318 hasConcept C71924100 @default.
• W4386425318 hasConcept C98274493 @default.
• W4386425318 hasConcept C99454951 @default.
• W4386425318 hasConceptScore W4386425318C112705442 @default.
• W4386425318 hasConceptScore W4386425318C203014093 @default.
• W4386425318 hasConceptScore W4386425318C2776120307 @default.
• W4386425318 hasConceptScore W4386425318C2777288759 @default.
• W4386425318 hasConceptScore W4386425318C2778048844 @default.
• W4386425318 hasConceptScore W4386425318C2778059366 @default.
• W4386425318 hasConceptScore W4386425318C2778371730 @default.
• W4386425318 hasConceptScore W4386425318C2780035454 @default.
• W4386425318 hasConceptScore W4386425318C2781160685 @default.
• W4386425318 hasConceptScore W4386425318C2908647359 @default.
• W4386425318 hasConceptScore W4386425318C71924100 @default.
• W4386425318 hasConceptScore W4386425318C98274493 @default.
• W4386425318 hasConceptScore W4386425318C99454951 @default.
• W4386425318 hasFunder F4320311904 @default.
• W4386425318 hasLocation W43864253181 @default.
• W4386425318 hasLocation W43864253182 @default.
• W4386425318 hasOpenAccess W4386425318 @default.
• W4386425318 hasPrimaryLocation W43864253181 @default.
• W4386425318 hasRelatedWork W1902021372 @default.
• W4386425318 hasRelatedWork W1998356222 @default.
• W4386425318 hasRelatedWork W2020052983 @default.
• W4386425318 hasRelatedWork W2046445824 @default.
• W4386425318 hasRelatedWork W2094082567 @default.
• W4386425318 hasRelatedWork W2104300146 @default.
• W4386425318 hasRelatedWork W2348145511 @default.
• W4386425318 hasRelatedWork W2770888081 @default.
• W4386425318 hasRelatedWork W38628413 @default.

• next