Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386437940> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4386437940 endingPage "644" @default.
- W4386437940 startingPage "638" @default.
- W4386437940 abstract "Mechanical signal transduction are crucial for chondrocyte in response to mechanical cues during the growth, development and osteoarthritis (OA) of articular cartilage. Extracellular matrix (ECM) turnover regulates the matrix mechanical microenvironment of chondrocytes. Thus, understanding the mechanotransduction mechanisms during chondrocyte sensing the matrix mechanical microenvironment can develop effective targeted therapy for OA. In recent decades, growing evidences are rapidly advancing our understanding of the mechanical force-dependent cartilage remodeling and injury responses mediated by TRPV4 and PIEZOs. In this review, we highlighted the mechanosensing mechanism mediated by TRPV4 and PIEZOs during chondrocytes sensing mechanical microenvironment of the ECM. Additionally, the latest progress in the regulation of OA by inflammatory signals mediated by TRPV4 and PIEZOs was also introduced. These recent insights provide the potential mechanotheraputic strategies to target these channels and prevent cartilage degeneration associated with OA. This review will shed light on the pathogenesis of articular cartilage, searching clinical targeted therapies, and designing cell-induced biomaterials.软骨细胞转导机械力信号的力转导过程在关节软骨生长、发育和骨性关节炎（OA）过程中发挥着重要作用。在关节软骨中，细胞外基质代谢活动调控着软骨细胞的基质力学微环境。因此，理解软骨细胞感受基质力学微环境的力转导机制能够通过精准靶向机械力感受器有效建立OA治疗策略。近十几年，大量研究证实力敏感离子通道TRPV4和PIEZOs在关节软骨细胞中大量表达，而且介导机械力相关的软骨重塑和损伤响应。本文综述了软骨细胞感受基质力学微环境过程中TRPV4和PIEZOs介导的力感受和力响应方面的相关研究，同时也介绍了TRPV4和PIEZOs介导炎症信号调控骨性关节炎方面的进展。本文为理解关节软骨发病机制和寻求可能药物靶点，以及设计细胞诱导性生物材料提供了新思路。." @default.
- W4386437940 created "2023-09-06" @default.
- W4386437940 creator A5028455946 @default.
- W4386437940 creator A5037101462 @default.
- W4386437940 creator A5039837606 @default.
- W4386437940 creator A5050181587 @default.
- W4386437940 creator A5064495035 @default.
- W4386437940 creator A5092824682 @default.
- W4386437940 date "2023-08-25" @default.
- W4386437940 modified "2023-09-28" @default.
- W4386437940 title "[Research progress of chondrocyte mechanotransduction mediated by TRPV4 and PIEZOs]." @default.
- W4386437940 doi "https://doi.org/10.7507/1001-5515.202301029" @default.
- W4386437940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37666753" @default.
- W4386437940 hasPublicationYear "2023" @default.
- W4386437940 type Work @default.
- W4386437940 citedByCount "0" @default.
- W4386437940 crossrefType "journal-article" @default.
- W4386437940 hasAuthorship W4386437940A5028455946 @default.
- W4386437940 hasAuthorship W4386437940A5037101462 @default.
- W4386437940 hasAuthorship W4386437940A5039837606 @default.
- W4386437940 hasAuthorship W4386437940A5050181587 @default.
- W4386437940 hasAuthorship W4386437940A5064495035 @default.
- W4386437940 hasAuthorship W4386437940A5092824682 @default.
- W4386437940 hasConcept C105702510 @default.
- W4386437940 hasConcept C111472728 @default.
- W4386437940 hasConcept C138885662 @default.
- W4386437940 hasConcept C142724271 @default.
- W4386437940 hasConcept C169760540 @default.
- W4386437940 hasConcept C170493617 @default.
- W4386437940 hasConcept C181104049 @default.
- W4386437940 hasConcept C185592680 @default.
- W4386437940 hasConcept C189165786 @default.
- W4386437940 hasConcept C204787440 @default.
- W4386437940 hasConcept C2776164576 @default.
- W4386437940 hasConcept C2780550940 @default.
- W4386437940 hasConcept C2781403057 @default.
- W4386437940 hasConcept C3020332539 @default.
- W4386437940 hasConcept C50254741 @default.
- W4386437940 hasConcept C55493867 @default.
- W4386437940 hasConcept C71924100 @default.
- W4386437940 hasConcept C86803240 @default.
- W4386437940 hasConcept C89611455 @default.
- W4386437940 hasConcept C90420996 @default.
- W4386437940 hasConcept C95444343 @default.
- W4386437940 hasConceptScore W4386437940C105702510 @default.
- W4386437940 hasConceptScore W4386437940C111472728 @default.
- W4386437940 hasConceptScore W4386437940C138885662 @default.
- W4386437940 hasConceptScore W4386437940C142724271 @default.
- W4386437940 hasConceptScore W4386437940C169760540 @default.
- W4386437940 hasConceptScore W4386437940C170493617 @default.
- W4386437940 hasConceptScore W4386437940C181104049 @default.
- W4386437940 hasConceptScore W4386437940C185592680 @default.
- W4386437940 hasConceptScore W4386437940C189165786 @default.
- W4386437940 hasConceptScore W4386437940C204787440 @default.
- W4386437940 hasConceptScore W4386437940C2776164576 @default.
- W4386437940 hasConceptScore W4386437940C2780550940 @default.
- W4386437940 hasConceptScore W4386437940C2781403057 @default.
- W4386437940 hasConceptScore W4386437940C3020332539 @default.
- W4386437940 hasConceptScore W4386437940C50254741 @default.
- W4386437940 hasConceptScore W4386437940C55493867 @default.
- W4386437940 hasConceptScore W4386437940C71924100 @default.
- W4386437940 hasConceptScore W4386437940C86803240 @default.
- W4386437940 hasConceptScore W4386437940C89611455 @default.
- W4386437940 hasConceptScore W4386437940C90420996 @default.
- W4386437940 hasConceptScore W4386437940C95444343 @default.
- W4386437940 hasIssue "4" @default.
- W4386437940 hasLocation W43864379401 @default.
- W4386437940 hasOpenAccess W4386437940 @default.
- W4386437940 hasPrimaryLocation W43864379401 @default.
- W4386437940 hasRelatedWork W1512545208 @default.
- W4386437940 hasRelatedWork W1968203093 @default.
- W4386437940 hasRelatedWork W1988373706 @default.
- W4386437940 hasRelatedWork W2033329636 @default.
- W4386437940 hasRelatedWork W2324747502 @default.
- W4386437940 hasRelatedWork W2365956654 @default.
- W4386437940 hasRelatedWork W2378255905 @default.
- W4386437940 hasRelatedWork W2473018992 @default.
- W4386437940 hasRelatedWork W2516164232 @default.
- W4386437940 hasRelatedWork W3157513908 @default.
- W4386437940 hasVolume "40" @default.
- W4386437940 isParatext "false" @default.
- W4386437940 isRetracted "false" @default.
- W4386437940 workType "article" @default.