Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386442337> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4386442337 abstract "Abstract Neurogenesis and proliferation of neural stem cells (NSCs) in the subventricular zone (SVZ) are controlled by both intrinsic molecular pathways and extrinsic signaling cues, including neural circuits. One such circuit, the ACC-subep-ChAT + circuit, has been identified as a regulator of ventral SVZ neurogenesis by modulating the proliferation of LV NSCs. However, the specific neural signals that promote the proliferation activity of LV NSCs have remained largely unknown. In this study, we uncover a molecular mechanism underlying the cellular activation and proliferation of quiescent NSCs (qNSCs) in the lateral ventricle SVZ (LV-SVZ) mediated by the cortical circuit. Our findings demonstrate that postnatal and adult LV qNSCs are triggered by the cortical circuit through ChAT + neuron stimulation, consequently resulting in the activation of muscarinic 3 receptors (M3) expressed on LV qNSCs. This, in turn, triggers inositol 1,4,5-trisphosphate receptor type 1 (IP3R1) activation, causing intracellular calcium release. Subsequently, the proliferation of LV qNSCs occurs through the downstream regulation of the calcium/calmodulin dependent protein kinase II delta (CAMK2D) and the MAPK10 signaling pathway. These findings shed light on the molecular regulatory mechanisms that govern LV qNSCs and emphasize the significant role of the cortical circuit in promoting their proliferative activation within the ventral LV-SVZ." @default.
- W4386442337 created "2023-09-06" @default.
- W4386442337 creator A5027117815 @default.
- W4386442337 creator A5029968554 @default.
- W4386442337 date "2023-09-05" @default.
- W4386442337 modified "2023-09-27" @default.
- W4386442337 title "Muscarinic Signaling Pathway Controls Cortical Circuit Regulation of Lateral Ventricle Quiescent Neural Stem Cells" @default.
- W4386442337 cites W1745534060 @default.
- W4386442337 cites W1848864628 @default.
- W4386442337 cites W1853414269 @default.
- W4386442337 cites W1928317628 @default.
- W4386442337 cites W1964468906 @default.
- W4386442337 cites W1968911616 @default.
- W4386442337 cites W1974018894 @default.
- W4386442337 cites W1974791004 @default.
- W4386442337 cites W1988896202 @default.
- W4386442337 cites W2007242343 @default.
- W4386442337 cites W2010054551 @default.
- W4386442337 cites W2011232162 @default.
- W4386442337 cites W2012253237 @default.
- W4386442337 cites W2023500019 @default.
- W4386442337 cites W2024035512 @default.
- W4386442337 cites W2035250926 @default.
- W4386442337 cites W2051430216 @default.
- W4386442337 cites W2060850575 @default.
- W4386442337 cites W2065970275 @default.
- W4386442337 cites W2067927644 @default.
- W4386442337 cites W2077439063 @default.
- W4386442337 cites W2089966630 @default.
- W4386442337 cites W2090249462 @default.
- W4386442337 cites W2092319653 @default.
- W4386442337 cites W2093502142 @default.
- W4386442337 cites W2107495112 @default.
- W4386442337 cites W2109719538 @default.
- W4386442337 cites W2118565754 @default.
- W4386442337 cites W2141535241 @default.
- W4386442337 cites W2155076048 @default.
- W4386442337 cites W2165104370 @default.
- W4386442337 cites W2165867905 @default.
- W4386442337 cites W2168363131 @default.
- W4386442337 cites W2172245356 @default.
- W4386442337 cites W2177341172 @default.
- W4386442337 cites W2319605272 @default.
- W4386442337 cites W2786235809 @default.
- W4386442337 cites W2805257646 @default.
- W4386442337 cites W2903124740 @default.
- W4386442337 cites W2915097886 @default.
- W4386442337 cites W3010775569 @default.
- W4386442337 cites W3015997124 @default.
- W4386442337 cites W3094650086 @default.
- W4386442337 cites W3097219478 @default.
- W4386442337 cites W4296458937 @default.
- W4386442337 cites W4383620036 @default.
- W4386442337 doi "https://doi.org/10.1101/2023.09.02.556037" @default.
- W4386442337 hasPublicationYear "2023" @default.
- W4386442337 type Work @default.
- W4386442337 citedByCount "0" @default.
- W4386442337 crossrefType "posted-content" @default.
- W4386442337 hasAuthorship W4386442337A5027117815 @default.
- W4386442337 hasAuthorship W4386442337A5029968554 @default.
- W4386442337 hasBestOaLocation W43864423371 @default.
- W4386442337 hasConcept C136834591 @default.
- W4386442337 hasConcept C169760540 @default.
- W4386442337 hasConcept C2777542384 @default.
- W4386442337 hasConcept C28328180 @default.
- W4386442337 hasConcept C4746552 @default.
- W4386442337 hasConcept C86803240 @default.
- W4386442337 hasConcept C95444343 @default.
- W4386442337 hasConceptScore W4386442337C136834591 @default.
- W4386442337 hasConceptScore W4386442337C169760540 @default.
- W4386442337 hasConceptScore W4386442337C2777542384 @default.
- W4386442337 hasConceptScore W4386442337C28328180 @default.
- W4386442337 hasConceptScore W4386442337C4746552 @default.
- W4386442337 hasConceptScore W4386442337C86803240 @default.
- W4386442337 hasConceptScore W4386442337C95444343 @default.
- W4386442337 hasLocation W43864423371 @default.
- W4386442337 hasOpenAccess W4386442337 @default.
- W4386442337 hasPrimaryLocation W43864423371 @default.
- W4386442337 hasRelatedWork W1521652786 @default.
- W4386442337 hasRelatedWork W2028948697 @default.
- W4386442337 hasRelatedWork W2104934532 @default.
- W4386442337 hasRelatedWork W2130946516 @default.
- W4386442337 hasRelatedWork W2135046848 @default.
- W4386442337 hasRelatedWork W2325666967 @default.
- W4386442337 hasRelatedWork W233354604 @default.
- W4386442337 hasRelatedWork W2914367266 @default.
- W4386442337 hasRelatedWork W4244950130 @default.
- W4386442337 hasRelatedWork W69835883 @default.
- W4386442337 isParatext "false" @default.
- W4386442337 isRetracted "false" @default.
- W4386442337 workType "article" @default.