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- W4386444327 abstract "Reconstructing large craniofacial tissue defects, particularly those in the tongue following surgery for oral cancer, is a significant challenge in oral and maxillofacial surgery. Although progress has been made in reconstructive techniques, restoring full tongue function remains difficult.1 The current gold standard is to use microvascular soft tissue free flaps, but these do not fully restore the muscular and functional aspects of the tongue and can also result in donor site complications. In recent years, researchers have been exploring the use of mesenchymal stem cells (MSCs) and their derivatives, such as extracellular vesicles (EVs), in combination with biomaterials to develop tissue engineering and regenerative products that can help repair damaged tissues. A recent study found that using EVs from gingiva-derived MSCs (GMSC-EVs) along with porcine small intestine submucosa extracellular matrix (SIS-ECM) can facilitate myomucosal regeneration in rats with tongue defects.2" @default.
- W4386444327 created "2023-09-06" @default.
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- W4386444327 date "2023-09-01" @default.
- W4386444327 modified "2023-09-27" @default.
- W4386444327 title "Beyond Free Flaps: The Promising Role of GMSC-Derived Extracellular Vesicles in Tongue Reconstruction" @default.
- W4386444327 doi "https://doi.org/10.1016/j.joms.2023.08.146" @default.
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