Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386444658> ?p ?o ?g. }
- W4386444658 abstract "An instructive role for metabolism in embryonic patterning is emerging, although a role for mitochondria is poorly defined. We demonstrate that mitochondrial oxidative metabolism establishes the embryonic patterning center, the Spemann-Mangold Organizer, via hypoxia-inducible factor 1α (Hif-1α) in Xenopus. Hypoxia or decoupling ATP production from oxygen consumption expands the Organizer by activating Hif-1α. In addition, oxygen consumption is 20% higher in the Organizer than in the ventral mesoderm, indicating an elevation in mitochondrial respiration. To reconcile increased mitochondrial respiration with activation of Hif-1α, we discovered that the “free” c-subunit ring of the F1Fo ATP synthase creates an inner mitochondrial membrane leak, which decouples ATP production from respiration at the Organizer, driving Hif-1α activation there. Overexpression of either the c-subunit or Hif-1α is sufficient to induce Organizer cell fates even when β-catenin is inhibited. We propose that mitochondrial leak metabolism could be a general mechanism for activating Hif-1α and Wnt signaling." @default.
- W4386444658 created "2023-09-06" @default.
- W4386444658 creator A5000896516 @default.
- W4386444658 creator A5001396855 @default.
- W4386444658 creator A5002386330 @default.
- W4386444658 creator A5060297696 @default.
- W4386444658 creator A5067795566 @default.
- W4386444658 creator A5077778488 @default.
- W4386444658 creator A5077792733 @default.
- W4386444658 creator A5086493602 @default.
- W4386444658 creator A5092756924 @default.
- W4386444658 date "2023-09-01" @default.
- W4386444658 modified "2023-10-16" @default.
- W4386444658 title "Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus" @default.
- W4386444658 cites W1481324524 @default.
- W4386444658 cites W1525764529 @default.
- W4386444658 cites W1526227860 @default.
- W4386444658 cites W1553978925 @default.
- W4386444658 cites W160236471 @default.
- W4386444658 cites W1796950446 @default.
- W4386444658 cites W1862688974 @default.
- W4386444658 cites W1874303456 @default.
- W4386444658 cites W1897999350 @default.
- W4386444658 cites W1915704240 @default.
- W4386444658 cites W1963954608 @default.
- W4386444658 cites W1965446416 @default.
- W4386444658 cites W1965588143 @default.
- W4386444658 cites W1968461724 @default.
- W4386444658 cites W1971175769 @default.
- W4386444658 cites W1972604738 @default.
- W4386444658 cites W1972782503 @default.
- W4386444658 cites W1984288177 @default.
- W4386444658 cites W1985439298 @default.
- W4386444658 cites W1989721036 @default.
- W4386444658 cites W1989910300 @default.
- W4386444658 cites W1990938412 @default.
- W4386444658 cites W1990989076 @default.
- W4386444658 cites W1995091371 @default.
- W4386444658 cites W2000528338 @default.
- W4386444658 cites W2005870745 @default.
- W4386444658 cites W2006604617 @default.
- W4386444658 cites W2008999766 @default.
- W4386444658 cites W2011810742 @default.
- W4386444658 cites W2012804105 @default.
- W4386444658 cites W2015483723 @default.
- W4386444658 cites W2017742632 @default.
- W4386444658 cites W2018504915 @default.
- W4386444658 cites W2021432629 @default.
- W4386444658 cites W2024279589 @default.
- W4386444658 cites W2025019677 @default.
- W4386444658 cites W2026112588 @default.
- W4386444658 cites W2027705428 @default.
- W4386444658 cites W2028327476 @default.
- W4386444658 cites W2032546372 @default.
- W4386444658 cites W2032583877 @default.
- W4386444658 cites W2033958147 @default.
- W4386444658 cites W2035246304 @default.
- W4386444658 cites W2035593743 @default.
- W4386444658 cites W2037049906 @default.
- W4386444658 cites W2039155076 @default.
- W4386444658 cites W2044288458 @default.
- W4386444658 cites W2047165320 @default.
- W4386444658 cites W2051531582 @default.
- W4386444658 cites W2052238247 @default.
- W4386444658 cites W2052737683 @default.
- W4386444658 cites W2054091111 @default.
- W4386444658 cites W2055302859 @default.
- W4386444658 cites W2060262332 @default.
- W4386444658 cites W2061052195 @default.
- W4386444658 cites W2063250341 @default.
- W4386444658 cites W2064696266 @default.
- W4386444658 cites W2065582754 @default.
- W4386444658 cites W2070915058 @default.
- W4386444658 cites W2071135527 @default.
- W4386444658 cites W2076598575 @default.
- W4386444658 cites W2082973248 @default.
- W4386444658 cites W2087377825 @default.
- W4386444658 cites W2087814592 @default.
- W4386444658 cites W2088553907 @default.
- W4386444658 cites W2090636859 @default.
- W4386444658 cites W2098972920 @default.
- W4386444658 cites W2104158696 @default.
- W4386444658 cites W2104276565 @default.
- W4386444658 cites W2106133121 @default.
- W4386444658 cites W2106998229 @default.
- W4386444658 cites W2115686163 @default.
- W4386444658 cites W2118336842 @default.
- W4386444658 cites W2119273342 @default.
- W4386444658 cites W2121053966 @default.
- W4386444658 cites W2123911142 @default.
- W4386444658 cites W2125068279 @default.
- W4386444658 cites W2128817019 @default.
- W4386444658 cites W2133291915 @default.
- W4386444658 cites W2138954281 @default.
- W4386444658 cites W2141926453 @default.
- W4386444658 cites W2143302229 @default.
- W4386444658 cites W2143505819 @default.
- W4386444658 cites W2144076366 @default.
- W4386444658 cites W2144300167 @default.
- W4386444658 cites W2147609603 @default.