Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386446579> ?p ?o ?g. }
- W4386446579 abstract "Abstract Undruggable proteins are a class of proteins that are often characterized by large, complex structures or functions that are difficult to interfere with using conventional drug design strategies. Targeting such undruggable targets has been considered also a great opportunity for treatment of human diseases and has attracted substantial efforts in the field of medicine. Therefore, in this review, we focus on the recent development of drug discovery targeting “undruggable” proteins and their application in clinic. To make this review well organized, we discuss the design strategies targeting the undruggable proteins, including covalent regulation, allosteric inhibition, protein–protein/DNA interaction inhibition, targeted proteins regulation, nucleic acid-based approach, immunotherapy and others." @default.
- W4386446579 created "2023-09-06" @default.
- W4386446579 creator A5009318195 @default.
- W4386446579 creator A5011125335 @default.
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- W4386446579 creator A5022454880 @default.
- W4386446579 creator A5044695259 @default.
- W4386446579 creator A5048257624 @default.
- W4386446579 creator A5072809229 @default.
- W4386446579 creator A5074467611 @default.
- W4386446579 date "2023-09-06" @default.
- W4386446579 modified "2023-10-10" @default.
- W4386446579 title "Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials" @default.
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