Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386448191> ?p ?o ?g. }
- W4386448191 endingPage "13755" @default.
- W4386448191 startingPage "13750" @default.
- W4386448191 abstract "Perfluorooctanesulfonic acid (PFOS) is a commonly found environmental pollutant with potential toxicity and health risks to biosystems and ecosystems. Study of the accumulation behavior and heterogeneity of PFOS in biological primary organ cells provides us significant insights to explore its cytotoxicity, carcinogenicity, and mutagenicity. Here a single-cell mass cytometry system was established for the high-throughput analysis of trace PFOS and the exploration of its accumulation behavior and heterogeneity in zebrafish primary organ cells. The single-cell mass cytometry system applied a ∼25 μm constant-inner-diameter capillary as the single-cell generation and transportation channel with an etched tip-end of 40 μm as the nanoelectrospray emitter for mass spectrometric analysis. The single-cell mass cytometry system showed satisfactory semiquantitative performance and sensitivity for analysis of PFOS in single cells, with a high detection throughput of ∼35 cells/min. Subsequently, the liver, intestine, heart, and brain from PFOS-exposed zebrafish (100 pg/μL, 28 days) were dissociated and prepared as cell suspensions, and the cell suspensions were introduced into the single-cell mass cytometry system for high-throughput analysis of PFOS in individual primary organ cells. Significant cellular accumulation heterogeneities were observed, with the highest content in liver cells, followed by intestine cells, then heart cells, and the lowest in brain cells. In addition, the dynamics of PFOS in the zebrafish liver, intestine, heart, and brain cells showed typical violin plot distributions and were well-described using a gamma (γ) function." @default.
- W4386448191 created "2023-09-06" @default.
- W4386448191 creator A5013249496 @default.
- W4386448191 creator A5016074858 @default.
- W4386448191 creator A5021339363 @default.
- W4386448191 creator A5023089689 @default.
- W4386448191 creator A5029106686 @default.
- W4386448191 creator A5042627512 @default.
- W4386448191 creator A5056340272 @default.
- W4386448191 creator A5073084663 @default.
- W4386448191 date "2023-09-05" @default.
- W4386448191 modified "2023-10-16" @default.
- W4386448191 title "Exploring the Accumulation Behavior and Heterogeneity of Perfluorooctanesulfonic Acid in Zebrafish Primary Organ Cells by Single-Cell Mass Cytometry" @default.
- W4386448191 cites W1971958233 @default.
- W4386448191 cites W2013337492 @default.
- W4386448191 cites W2030618194 @default.
- W4386448191 cites W2039774973 @default.
- W4386448191 cites W2075442155 @default.
- W4386448191 cites W2121075234 @default.
- W4386448191 cites W2288192121 @default.
- W4386448191 cites W2315376186 @default.
- W4386448191 cites W2316088817 @default.
- W4386448191 cites W2340182804 @default.
- W4386448191 cites W2419346047 @default.
- W4386448191 cites W2590237614 @default.
- W4386448191 cites W2592168063 @default.
- W4386448191 cites W2884971342 @default.
- W4386448191 cites W2952319526 @default.
- W4386448191 cites W2955888279 @default.
- W4386448191 cites W3042425731 @default.
- W4386448191 cites W3093527915 @default.
- W4386448191 cites W3133711424 @default.
- W4386448191 cites W3160721338 @default.
- W4386448191 cites W3167634451 @default.
- W4386448191 cites W3178285705 @default.
- W4386448191 cites W3202147738 @default.
- W4386448191 cites W4282918610 @default.
- W4386448191 cites W4285256008 @default.
- W4386448191 cites W4313397479 @default.
- W4386448191 cites W4319074599 @default.
- W4386448191 cites W4322725115 @default.
- W4386448191 doi "https://doi.org/10.1021/acs.analchem.3c02398" @default.
- W4386448191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37669419" @default.
- W4386448191 hasPublicationYear "2023" @default.
- W4386448191 type Work @default.
- W4386448191 citedByCount "0" @default.
- W4386448191 crossrefType "journal-article" @default.
- W4386448191 hasAuthorship W4386448191A5013249496 @default.
- W4386448191 hasAuthorship W4386448191A5016074858 @default.
- W4386448191 hasAuthorship W4386448191A5021339363 @default.
- W4386448191 hasAuthorship W4386448191A5023089689 @default.
- W4386448191 hasAuthorship W4386448191A5029106686 @default.
- W4386448191 hasAuthorship W4386448191A5042627512 @default.
- W4386448191 hasAuthorship W4386448191A5056340272 @default.
- W4386448191 hasAuthorship W4386448191A5073084663 @default.
- W4386448191 hasConcept C104317684 @default.
- W4386448191 hasConcept C12554922 @default.
- W4386448191 hasConcept C127716648 @default.
- W4386448191 hasConcept C1491633281 @default.
- W4386448191 hasConcept C153911025 @default.
- W4386448191 hasConcept C185592680 @default.
- W4386448191 hasConcept C2776878037 @default.
- W4386448191 hasConcept C2776950831 @default.
- W4386448191 hasConcept C2778015335 @default.
- W4386448191 hasConcept C2778630268 @default.
- W4386448191 hasConcept C2780339063 @default.
- W4386448191 hasConcept C553184892 @default.
- W4386448191 hasConcept C55493867 @default.
- W4386448191 hasConcept C86803240 @default.
- W4386448191 hasConcept C95444343 @default.
- W4386448191 hasConceptScore W4386448191C104317684 @default.
- W4386448191 hasConceptScore W4386448191C12554922 @default.
- W4386448191 hasConceptScore W4386448191C127716648 @default.
- W4386448191 hasConceptScore W4386448191C1491633281 @default.
- W4386448191 hasConceptScore W4386448191C153911025 @default.
- W4386448191 hasConceptScore W4386448191C185592680 @default.
- W4386448191 hasConceptScore W4386448191C2776878037 @default.
- W4386448191 hasConceptScore W4386448191C2776950831 @default.
- W4386448191 hasConceptScore W4386448191C2778015335 @default.
- W4386448191 hasConceptScore W4386448191C2778630268 @default.
- W4386448191 hasConceptScore W4386448191C2780339063 @default.
- W4386448191 hasConceptScore W4386448191C553184892 @default.
- W4386448191 hasConceptScore W4386448191C55493867 @default.
- W4386448191 hasConceptScore W4386448191C86803240 @default.
- W4386448191 hasConceptScore W4386448191C95444343 @default.
- W4386448191 hasFunder F4320321001 @default.
- W4386448191 hasFunder F4320337111 @default.
- W4386448191 hasIssue "37" @default.
- W4386448191 hasLocation W43864481911 @default.
- W4386448191 hasLocation W43864481912 @default.
- W4386448191 hasOpenAccess W4386448191 @default.
- W4386448191 hasPrimaryLocation W43864481911 @default.
- W4386448191 hasRelatedWork W2542672407 @default.
- W4386448191 hasRelatedWork W2727096535 @default.
- W4386448191 hasRelatedWork W2744301679 @default.
- W4386448191 hasRelatedWork W2791581835 @default.
- W4386448191 hasRelatedWork W2889594596 @default.
- W4386448191 hasRelatedWork W3004379864 @default.