Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386448277> ?p ?o ?g. }
- W4386448277 endingPage "13856" @default.
- W4386448277 startingPage "13848" @default.
- W4386448277 abstract "l-Cysteine is a valuable sulfur-containing amino acid with applications across a wide range of fields. Recently, microbial fermentation has emerged as a method to produce l-cysteine. However, cellular redox stress from high levels of l-cysteine is a bottleneck for achieving efficient production. In this study, we aimed to facilitate l-cysteine biosynthesis by modulating cellular redox homeostasis through the introduction of the natural antioxidant astaxanthin in Corynebacterium glutamicum. To achieve this, we first introduced an exogenous astaxanthin synthesis module in C. glutamicum. Then, an l-cysteine-dependent autonomous bifunctional genetic switch was developed to dynamically regulate the l-cysteine and astaxanthin biosynthesis pathway to maintain cellular redox homeostasis. This regulation system achieved high biosynthesis of astaxanthin, which significantly facilitated l-cysteine production. Finally, engineered strain Cg-10 produced 8.45 g/L l-cysteine and 95 mg/L astaxanthin in a 5 L bioreactor, both of which are the highest reported levels in C. glutamicum." @default.
- W4386448277 created "2023-09-06" @default.
- W4386448277 creator A5005691707 @default.
- W4386448277 creator A5013044543 @default.
- W4386448277 creator A5037633294 @default.
- W4386448277 creator A5041517373 @default.
- W4386448277 creator A5063967794 @default.
- W4386448277 creator A5079272207 @default.
- W4386448277 creator A5085357348 @default.
- W4386448277 creator A5089718840 @default.
- W4386448277 date "2023-09-05" @default.
- W4386448277 modified "2023-10-08" @default.
- W4386448277 title "Balancing Redox Homeostasis to Improve <scp>l</scp>-Cysteine Production in <i>Corynebacterium glutamicum</i>" @default.
- W4386448277 cites W1574002303 @default.
- W4386448277 cites W1979287129 @default.
- W4386448277 cites W2025038110 @default.
- W4386448277 cites W2037920917 @default.
- W4386448277 cites W2056386224 @default.
- W4386448277 cites W2063641945 @default.
- W4386448277 cites W2065095031 @default.
- W4386448277 cites W2077361309 @default.
- W4386448277 cites W2106918722 @default.
- W4386448277 cites W2124688646 @default.
- W4386448277 cites W2137793738 @default.
- W4386448277 cites W2152224886 @default.
- W4386448277 cites W2460756007 @default.
- W4386448277 cites W2535095745 @default.
- W4386448277 cites W2551155733 @default.
- W4386448277 cites W2561831109 @default.
- W4386448277 cites W2563717514 @default.
- W4386448277 cites W2618054500 @default.
- W4386448277 cites W2756789001 @default.
- W4386448277 cites W2765206790 @default.
- W4386448277 cites W2765756425 @default.
- W4386448277 cites W2793893203 @default.
- W4386448277 cites W2796160246 @default.
- W4386448277 cites W2894132914 @default.
- W4386448277 cites W2901006478 @default.
- W4386448277 cites W2904082980 @default.
- W4386448277 cites W2927318903 @default.
- W4386448277 cites W2943940584 @default.
- W4386448277 cites W2964834922 @default.
- W4386448277 cites W2971907845 @default.
- W4386448277 cites W2982551297 @default.
- W4386448277 cites W2995371081 @default.
- W4386448277 cites W3083459141 @default.
- W4386448277 cites W3087326082 @default.
- W4386448277 cites W3109823762 @default.
- W4386448277 cites W3126411385 @default.
- W4386448277 cites W3164714144 @default.
- W4386448277 cites W3217632767 @default.
- W4386448277 cites W4220720695 @default.
- W4386448277 cites W4288926378 @default.
- W4386448277 cites W4328022379 @default.
- W4386448277 doi "https://doi.org/10.1021/acs.jafc.3c03828" @default.
- W4386448277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37669547" @default.
- W4386448277 hasPublicationYear "2023" @default.
- W4386448277 type Work @default.
- W4386448277 citedByCount "0" @default.
- W4386448277 crossrefType "journal-article" @default.
- W4386448277 hasAuthorship W4386448277A5005691707 @default.
- W4386448277 hasAuthorship W4386448277A5013044543 @default.
- W4386448277 hasAuthorship W4386448277A5037633294 @default.
- W4386448277 hasAuthorship W4386448277A5041517373 @default.
- W4386448277 hasAuthorship W4386448277A5063967794 @default.
- W4386448277 hasAuthorship W4386448277A5079272207 @default.
- W4386448277 hasAuthorship W4386448277A5085357348 @default.
- W4386448277 hasAuthorship W4386448277A5089718840 @default.
- W4386448277 hasConcept C100544194 @default.
- W4386448277 hasConcept C104317684 @default.
- W4386448277 hasConcept C178790620 @default.
- W4386448277 hasConcept C181199279 @default.
- W4386448277 hasConcept C185592680 @default.
- W4386448277 hasConcept C2776260651 @default.
- W4386448277 hasConcept C2779201268 @default.
- W4386448277 hasConcept C553450214 @default.
- W4386448277 hasConcept C55493867 @default.
- W4386448277 hasConcept C55904794 @default.
- W4386448277 hasConcept C6350086 @default.
- W4386448277 hasConcept C86803240 @default.
- W4386448277 hasConceptScore W4386448277C100544194 @default.
- W4386448277 hasConceptScore W4386448277C104317684 @default.
- W4386448277 hasConceptScore W4386448277C178790620 @default.
- W4386448277 hasConceptScore W4386448277C181199279 @default.
- W4386448277 hasConceptScore W4386448277C185592680 @default.
- W4386448277 hasConceptScore W4386448277C2776260651 @default.
- W4386448277 hasConceptScore W4386448277C2779201268 @default.
- W4386448277 hasConceptScore W4386448277C553450214 @default.
- W4386448277 hasConceptScore W4386448277C55493867 @default.
- W4386448277 hasConceptScore W4386448277C55904794 @default.
- W4386448277 hasConceptScore W4386448277C6350086 @default.
- W4386448277 hasConceptScore W4386448277C86803240 @default.
- W4386448277 hasFunder F4320321001 @default.
- W4386448277 hasFunder F4320335777 @default.
- W4386448277 hasIssue "37" @default.
- W4386448277 hasLocation W43864482771 @default.
- W4386448277 hasLocation W43864482772 @default.
- W4386448277 hasOpenAccess W4386448277 @default.