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- W4386449418 abstract "Abstract Drosophila remains a pre-eminent insect model system for host-virus interaction, but the host range and fitness consequences of the drosophilid virome are poorly understood. Metagenomic studies have reported over 160 viruses associated with Drosophilidae , but few isolates are available to characterise the Drosophila immune response, and most characterisation has relied on injection and systemic infection. Here we use a more natural infection route to characterise the fitness effects of infection and to study a wider range of viruses. We exposed laboratory D. melanogaster to 23 naturally occurring viruses from wild-collected drosophilids. We recorded transmission rates along with two components of female fitness: survival and the lifetime number of adult offspring produced. Nine different viruses transmitted during contact with laboratory D. melanogaster , although for the majority, rates of transmission were less than 20%. Five virus infections led to a significant decrease in lifespan (D. melanogaster nora virus, D. immigrans nora virus, Muthill virus, galbut virus and Prestney Burn virus), and three led to a reduction in the total number of offspring. Our findings demonstrate the utility of the Drosophila model for community-level studies of host-virus interactions, and suggest that viral infection could be a substantial fitness burden on wild flies." @default.
- W4386449418 created "2023-09-06" @default.
- W4386449418 creator A5041375754 @default.
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- W4386449418 date "2023-09-05" @default.
- W4386449418 modified "2023-09-27" @default.
- W4386449418 title "Naturally occurring viruses of Drosophila reduce offspring number and lifespan" @default.
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- W4386449418 doi "https://doi.org/10.1101/2023.09.05.555738" @default.
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