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- W4386449557 abstract "Summary What developmental mechanisms underlie functional diversification of neural circuits? We address this question in Drosophila larvae by focusing on segmentally homologous Wave command neurons, which diversify their wiring and function in a location-specific manner. Anterior Wave (a-Wave) neurons extend axons anteriorly and connect to circuits inducing backward locomotion, whereas posterior Wave (p-Wave) neurons extend axons posteriorly and trigger forward locomotion. Here, we show that Frizzled receptors DFz2 and DFz4, together with the DWnt4 ligand, regulate the segment-specific Wave axon projection. DFz2 knock-down (KD) not only reroutes a-Wave axons to posterior neuromeres but also biases its motor command to induce forward instead of backward locomotion. Thus, segment-specific axon guidance diversifies the function of homologous command neurons in behavioral regulation. Since control of anterior-posterior (A-P) axon guidance by Wnt/Fz-signaling is evolutionarily conserved, our results reveal a potentially universal principle for formation and diversification of the command system in the nerve cord." @default.
- W4386449557 created "2023-09-06" @default.
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- W4386449557 date "2023-09-05" @default.
- W4386449557 modified "2023-10-16" @default.
- W4386449557 title "Segment-specific axon guidance by Wnt/Fz signaling diversifies motor commands in Drosophila larvae" @default.
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- W4386449557 doi "https://doi.org/10.1101/2023.09.05.555126" @default.
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