FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386458093> ?p ?o ?g. }

• W4386458093 abstract "Introduction: Platinum-based chemotherapy is the first-line treatment strategy for ovarian cancer patients. The dismal prognosis of ovarian cancer was shown to be stringently associated with the heterogeneity of tumor cells in response to this therapy, therefore understanding platinum sensitivity in ovarian cancer would be helpful for improving patients’ quality of life and clinical outcomes. HRDetect, utilized to characterize patients’ homologous recombination repair deficiency, was used to predict patients’ response to platinum-based chemotherapy. However, whether each of the single features contributing to HRD score is associated with platinum sensitivity remains elusive. Methods: We analyzed the whole-exome sequencing data of 196 patients who received platinum-based chemotherapy from the TCGA database. Genetic features were determined individually to see if they could indicate patients’ response to platinum-based chemotherapy and prognosis, then integrated into a Pt-score employing LASSO regression model to assess its predictive performance. Results and discussion: Multiple genetic features, including bi-allelic inactivation of BRCA1/2 genes and genes involved in HR pathway, multiple somatic mutations in genes involved in DNA damage repair (DDR), and previously reported HRD-related features, were found to be stringently associated with platinum sensitivity and improved prognosis. Higher contributions of mutational signature SBS39 or ID6 predicted improved overall survival. Besides, arm-level loss of heterozygosity (LOH) of either chr4p or chr5q predicted significantly better disease-free survival. Notably, some of these features were found independent of HRD. And SBS3, an HRD-related feature, was found irrelevant to platinum sensitivity. Integrated all candidate markers using the LASSO model to yield a Pt-score, which showed better predictive ability compared to HRDetect in determining platinum sensitivity and predicting patients’ prognosis, and this performance was validated in an independent cohort. The outcomes of our study will be instrumental in devising effective strategies for treating ovarian cancer with platinum-based chemotherapy." @default.
• W4386458093 created "2023-09-06" @default.
• W4386458093 creator A5003799076 @default.
• W4386458093 creator A5021778652 @default.
• W4386458093 creator A5025963248 @default.
• W4386458093 creator A5029588473 @default.
• W4386458093 creator A5051541488 @default.
• W4386458093 creator A5055721210 @default.
• W4386458093 creator A5079525897 @default.
• W4386458093 creator A5089823903 @default.
• W4386458093 creator A5089966579 @default.
• W4386458093 date "2023-09-05" @default.
• W4386458093 modified "2023-09-28" @default.
• W4386458093 title "A novel marker integrating multiple genetic alterations better predicts platinum sensitivity in ovarian cancer than HRD score" @default.
• W4386458093 cites W1526705543 @default.
• W4386458093 cites W2005534721 @default.
• W4386458093 cites W2011033166 @default.
• W4386458093 cites W2038170131 @default.
• W4386458093 cites W2042633087 @default.
• W4386458093 cites W2059128931 @default.
• W4386458093 cites W2071966564 @default.
• W4386458093 cites W2074952360 @default.
• W4386458093 cites W2111715435 @default.
• W4386458093 cites W2142363848 @default.
• W4386458093 cites W2142658272 @default.
• W4386458093 cites W2152061559 @default.
• W4386458093 cites W2170454539 @default.
• W4386458093 cites W2515864258 @default.
• W4386458093 cites W2567144558 @default.
• W4386458093 cites W2567230103 @default.
• W4386458093 cites W2586629973 @default.
• W4386458093 cites W2596164112 @default.
• W4386458093 cites W2626537767 @default.
• W4386458093 cites W2749641460 @default.
• W4386458093 cites W2764292139 @default.
• W4386458093 cites W2771217224 @default.
• W4386458093 cites W2775269156 @default.
• W4386458093 cites W2795993993 @default.
• W4386458093 cites W2807649309 @default.
• W4386458093 cites W2899790658 @default.
• W4386458093 cites W2930305328 @default.
• W4386458093 cites W2976511826 @default.
• W4386458093 cites W2976898289 @default.
• W4386458093 cites W2984589472 @default.
• W4386458093 cites W3015646919 @default.
• W4386458093 cites W3021256483 @default.
• W4386458093 cites W3187517073 @default.
• W4386458093 cites W4210987384 @default.
• W4386458093 cites W4212835986 @default.
• W4386458093 cites W4282027230 @default.
• W4386458093 doi "https://doi.org/10.3389/fgene.2023.1240068" @default.
• W4386458093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37732324" @default.
• W4386458093 hasPublicationYear "2023" @default.
• W4386458093 type Work @default.
• W4386458093 citedByCount "0" @default.
• W4386458093 crossrefType "journal-article" @default.
• W4386458093 hasAuthorship W4386458093A5003799076 @default.
• W4386458093 hasAuthorship W4386458093A5021778652 @default.
• W4386458093 hasAuthorship W4386458093A5025963248 @default.
• W4386458093 hasAuthorship W4386458093A5029588473 @default.
• W4386458093 hasAuthorship W4386458093A5051541488 @default.
• W4386458093 hasAuthorship W4386458093A5055721210 @default.
• W4386458093 hasAuthorship W4386458093A5079525897 @default.
• W4386458093 hasAuthorship W4386458093A5089823903 @default.
• W4386458093 hasAuthorship W4386458093A5089966579 @default.
• W4386458093 hasBestOaLocation W43864580931 @default.
• W4386458093 hasConcept C104317684 @default.
• W4386458093 hasConcept C121608353 @default.
• W4386458093 hasConcept C126322002 @default.
• W4386458093 hasConcept C143589142 @default.
• W4386458093 hasConcept C143998085 @default.
• W4386458093 hasConcept C180754005 @default.
• W4386458093 hasConcept C2776694085 @default.
• W4386458093 hasConcept C2778239845 @default.
• W4386458093 hasConcept C2780427987 @default.
• W4386458093 hasConcept C2781451048 @default.
• W4386458093 hasConcept C54355233 @default.
• W4386458093 hasConcept C71924100 @default.
• W4386458093 hasConcept C86803240 @default.
• W4386458093 hasConceptScore W4386458093C104317684 @default.
• W4386458093 hasConceptScore W4386458093C121608353 @default.
• W4386458093 hasConceptScore W4386458093C126322002 @default.
• W4386458093 hasConceptScore W4386458093C143589142 @default.
• W4386458093 hasConceptScore W4386458093C143998085 @default.
• W4386458093 hasConceptScore W4386458093C180754005 @default.
• W4386458093 hasConceptScore W4386458093C2776694085 @default.
• W4386458093 hasConceptScore W4386458093C2778239845 @default.
• W4386458093 hasConceptScore W4386458093C2780427987 @default.
• W4386458093 hasConceptScore W4386458093C2781451048 @default.
• W4386458093 hasConceptScore W4386458093C54355233 @default.
• W4386458093 hasConceptScore W4386458093C71924100 @default.
• W4386458093 hasConceptScore W4386458093C86803240 @default.
• W4386458093 hasLocation W43864580931 @default.
• W4386458093 hasLocation W43864580932 @default.
• W4386458093 hasOpenAccess W4386458093 @default.
• W4386458093 hasPrimaryLocation W43864580931 @default.
• W4386458093 hasRelatedWork W1565683009 @default.
• W4386458093 hasRelatedWork W1967715255 @default.
• W4386458093 hasRelatedWork W2053778437 @default.
• W4386458093 hasRelatedWork W2123388967 @default.

• next