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- W4386460571 abstract "Microtubule asters are essential in localizing the action of microtubules in processes including mitosis and organelle positioning. In large cells, such as the one-cell sea urchin embryo, aster dynamics are dominated by hydrodynamic pulling forces. However, in systems with more densely positioned nuclei such as the early Drosophila embryo, which packs around 6000 nuclei within the syncytium in a crystalline-like order, it is unclear what processes dominate aster dynamics. Here, we take advantage of a cell cycle regulation Drosophila mutant to generate embryos with multiple asters, independent from nuclei. We use an ex vivo assay to further simplify this biological system to explore the forces generated by and between asters. Through live imaging, drug and optical perturbations, and theoretical modelling, we demonstrate that these asters likely generate an effective pushing force over short distances.Using cytosolic explants from Drosophila syncytial embryos combined with quantitative microscopy and perturbations, de-Carvalho et al., reveal the mechanical forces separating Drosophila microtubule asters. Aster separation drives precise nuclear positioning in multinucleated embryo cells, a vital process for tissue formation and gene expression during subsequent embryo development." @default.
- W4386460571 created "2023-09-06" @default.
- W4386460571 date "2023-09-05" @default.
- W4386460571 modified "2023-10-01" @default.
- W4386460571 title "Reviewer #2 (Public Review): The positioning mechanics of microtubule asters in Drosophila embryo explants" @default.
- W4386460571 doi "https://doi.org/10.7554/elife.90541.1.sa2" @default.
- W4386460571 hasPublicationYear "2023" @default.
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