FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386461708> ?p ?o ?g. }

• W4386461708 endingPage "2499" @default.
• W4386461708 startingPage "2499" @default.
• W4386461708 abstract "The traditional nanocarriers are typically constructed to deliver anticancer agents for improving drug bioavailability and enhancing chemotherapeutic efficacy, but this strategy suffers from the critical issue of nanocarrier biosafety that hinders further clinical translation. In this work, a unique nanomedicine (PTX@ICG) has been rationally constructed by combining two clinically approved agents, i.e., paclitaxel (PTX) and indocyanine green (ICG), by a facile ultrasound-assisted self-assembly methodology. The formation of the nanostructure can effectively increase the enrichment of PTX and ICG molecules in the tumor site, and improve the utilization factor of hydrophobic PTX. Moreover, since the molecule interaction in PTX@ICG is mainly Van der Waals forces, the self-assembled structure can be spontaneously dissociated under laser irradiation and release PTX in situ to achieve safe tumor-targeted chemotherapy. Simultaneously, the released ICG can act as photothermic agents for photothermal therapy (PTT), thus combining chemotherapy and PTT to obtain an enhanced tumor nanotherapy via facile self-assembly. The synergistic chemo/photothermal tumor nanotherapy achieved the efficient tumor cell-killing effect and tumor-ablation ability, as systematically demonstrated both in vitro and in vivo. This work provides a distinct paradigm of the self-assembled nanomedicine design for effectively improving the drug bioavailability to achieve high antitumor efficacy." @default.
• W4386461708 created "2023-09-06" @default.
• W4386461708 creator A5051090425 @default.
• W4386461708 creator A5070331732 @default.
• W4386461708 creator A5075247746 @default.
• W4386461708 date "2023-09-05" @default.
• W4386461708 modified "2023-10-17" @default.
• W4386461708 title "Engineering Self-Assembled Nanomedicines Composed of Clinically Approved Medicines for Enhanced Tumor Nanotherapy" @default.
• W4386461708 cites W1895317372 @default.
• W4386461708 cites W1983600538 @default.
• W4386461708 cites W2003845311 @default.
• W4386461708 cites W2009720434 @default.
• W4386461708 cites W2063470712 @default.
• W4386461708 cites W2072575671 @default.
• W4386461708 cites W2078571932 @default.
• W4386461708 cites W2089066127 @default.
• W4386461708 cites W2110123023 @default.
• W4386461708 cites W2117692326 @default.
• W4386461708 cites W2123505773 @default.
• W4386461708 cites W2256492013 @default.
• W4386461708 cites W2322194440 @default.
• W4386461708 cites W2416555361 @default.
• W4386461708 cites W2560728809 @default.
• W4386461708 cites W2607394468 @default.
• W4386461708 cites W2781221906 @default.
• W4386461708 cites W2794373765 @default.
• W4386461708 cites W2809199844 @default.
• W4386461708 cites W2835368321 @default.
• W4386461708 cites W2890451487 @default.
• W4386461708 cites W2895282589 @default.
• W4386461708 cites W2897712761 @default.
• W4386461708 cites W2909644885 @default.
• W4386461708 cites W2966389029 @default.
• W4386461708 cites W2969622832 @default.
• W4386461708 cites W2987244339 @default.
• W4386461708 cites W2998465238 @default.
• W4386461708 cites W3021165754 @default.
• W4386461708 cites W3022127046 @default.
• W4386461708 cites W3024966196 @default.
• W4386461708 cites W3036078844 @default.
• W4386461708 cites W3047178396 @default.
• W4386461708 cites W3050950703 @default.
• W4386461708 cites W3082913439 @default.
• W4386461708 cites W3100033019 @default.
• W4386461708 cites W3108163234 @default.
• W4386461708 cites W3118594892 @default.
• W4386461708 cites W3127713761 @default.
• W4386461708 cites W3136361346 @default.
• W4386461708 cites W3137415194 @default.
• W4386461708 cites W3137771756 @default.
• W4386461708 cites W3141159738 @default.
• W4386461708 cites W3161618640 @default.
• W4386461708 cites W3186415059 @default.
• W4386461708 cites W4319461334 @default.
• W4386461708 cites W4319999695 @default.
• W4386461708 cites W4361253122 @default.
• W4386461708 doi "https://doi.org/10.3390/nano13182499" @default.
• W4386461708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37764528" @default.
• W4386461708 hasPublicationYear "2023" @default.
• W4386461708 type Work @default.
• W4386461708 citedByCount "0" @default.
• W4386461708 crossrefType "journal-article" @default.
• W4386461708 hasAuthorship W4386461708A5051090425 @default.
• W4386461708 hasAuthorship W4386461708A5070331732 @default.
• W4386461708 hasAuthorship W4386461708A5075247746 @default.
• W4386461708 hasBestOaLocation W43864617081 @default.
• W4386461708 hasConcept C141071460 @default.
• W4386461708 hasConcept C15083742 @default.
• W4386461708 hasConcept C150903083 @default.
• W4386461708 hasConcept C155672457 @default.
• W4386461708 hasConcept C171250308 @default.
• W4386461708 hasConcept C181389837 @default.
• W4386461708 hasConcept C18150654 @default.
• W4386461708 hasConcept C182606246 @default.
• W4386461708 hasConcept C192562407 @default.
• W4386461708 hasConcept C207001950 @default.
• W4386461708 hasConcept C2776694085 @default.
• W4386461708 hasConcept C2777292972 @default.
• W4386461708 hasConcept C2779820397 @default.
• W4386461708 hasConcept C2781065829 @default.
• W4386461708 hasConcept C71924100 @default.
• W4386461708 hasConcept C86803240 @default.
• W4386461708 hasConcept C98274493 @default.
• W4386461708 hasConceptScore W4386461708C141071460 @default.
• W4386461708 hasConceptScore W4386461708C15083742 @default.
• W4386461708 hasConceptScore W4386461708C150903083 @default.
• W4386461708 hasConceptScore W4386461708C155672457 @default.
• W4386461708 hasConceptScore W4386461708C171250308 @default.
• W4386461708 hasConceptScore W4386461708C181389837 @default.
• W4386461708 hasConceptScore W4386461708C18150654 @default.
• W4386461708 hasConceptScore W4386461708C182606246 @default.
• W4386461708 hasConceptScore W4386461708C192562407 @default.
• W4386461708 hasConceptScore W4386461708C207001950 @default.
• W4386461708 hasConceptScore W4386461708C2776694085 @default.
• W4386461708 hasConceptScore W4386461708C2777292972 @default.
• W4386461708 hasConceptScore W4386461708C2779820397 @default.
• W4386461708 hasConceptScore W4386461708C2781065829 @default.
• W4386461708 hasConceptScore W4386461708C71924100 @default.

• next