Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386465377> ?p ?o ?g. }
- W4386465377 abstract "Intrahepatic cholangiocarcinoma (ICC) is a primary liver malignancy and is characterized by highly aggressive and malignant biological behavior. Currently, effective treatment strategies are limited. The effect of lenvatinib on ICC is unknown. In this study, we found that AZGP1 was the key target of lenvatinib in ICC, and its low expression in ICC cancer tissues was associated with a poor prognosis in patients. Lenvatinib is a novel AZGP1 agonist candidate for ICC that inhibits ICC-EMT by regulating the TGF-β1/Smad3 signaling pathway in an AZGP1-dependent manner. Furthermore, we found that lenvatinib could increase AZGP1 expression by increasing the acetylation level of H3K27Ac in the promoter region of the AZGP1 gene, thereby inhibiting EMT in ICC cells. In conclusion, lenvatinib activates AZGP1 by increasing the acetylation level of H3K27Ac on the AZGP1 promoter region and regulates the TGF-β1/Smad3 signaling pathway in an AZGP1-dependent manner to inhibit ICC-EMT. This study offers new insight into the mechanism of lenvatinib in the treatment of ICC and provides a theoretical basis for new treatment methods." @default.
- W4386465377 created "2023-09-06" @default.
- W4386465377 creator A5002458192 @default.
- W4386465377 creator A5016116228 @default.
- W4386465377 creator A5019752847 @default.
- W4386465377 creator A5026713312 @default.
- W4386465377 creator A5027873445 @default.
- W4386465377 creator A5029117570 @default.
- W4386465377 creator A5046908797 @default.
- W4386465377 creator A5048405476 @default.
- W4386465377 creator A5058429637 @default.
- W4386465377 creator A5061724140 @default.
- W4386465377 creator A5075683151 @default.
- W4386465377 creator A5082419716 @default.
- W4386465377 creator A5084989005 @default.
- W4386465377 creator A5086560872 @default.
- W4386465377 date "2023-09-05" @default.
- W4386465377 modified "2023-10-16" @default.
- W4386465377 title "AZGP1 activation by lenvatinib suppresses intrahepatic cholangiocarcinoma epithelial-mesenchymal transition through the TGF-β1/Smad3 pathway" @default.
- W4386465377 cites W1692971431 @default.
- W4386465377 cites W1760215417 @default.
- W4386465377 cites W1911261107 @default.
- W4386465377 cites W1918568431 @default.
- W4386465377 cites W1966091911 @default.
- W4386465377 cites W1971511780 @default.
- W4386465377 cites W1979728979 @default.
- W4386465377 cites W1993230696 @default.
- W4386465377 cites W1995760091 @default.
- W4386465377 cites W2011387799 @default.
- W4386465377 cites W2014428158 @default.
- W4386465377 cites W2015654354 @default.
- W4386465377 cites W2034584820 @default.
- W4386465377 cites W2037306480 @default.
- W4386465377 cites W2047992261 @default.
- W4386465377 cites W2064822275 @default.
- W4386465377 cites W2094109552 @default.
- W4386465377 cites W2110738400 @default.
- W4386465377 cites W2113962581 @default.
- W4386465377 cites W2115261608 @default.
- W4386465377 cites W2117247812 @default.
- W4386465377 cites W2117674153 @default.
- W4386465377 cites W2126496017 @default.
- W4386465377 cites W2127847089 @default.
- W4386465377 cites W2128027522 @default.
- W4386465377 cites W2128790046 @default.
- W4386465377 cites W2137373909 @default.
- W4386465377 cites W2139805080 @default.
- W4386465377 cites W2151600653 @default.
- W4386465377 cites W2154568166 @default.
- W4386465377 cites W2155521816 @default.
- W4386465377 cites W2157446798 @default.
- W4386465377 cites W2180850028 @default.
- W4386465377 cites W2257452128 @default.
- W4386465377 cites W2275265220 @default.
- W4386465377 cites W2293269107 @default.
- W4386465377 cites W2309818502 @default.
- W4386465377 cites W2560993675 @default.
- W4386465377 cites W2561318234 @default.
- W4386465377 cites W2572077158 @default.
- W4386465377 cites W2734361535 @default.
- W4386465377 cites W2740522148 @default.
- W4386465377 cites W2763492611 @default.
- W4386465377 cites W2770576134 @default.
- W4386465377 cites W2786843484 @default.
- W4386465377 cites W2787358630 @default.
- W4386465377 cites W2789297669 @default.
- W4386465377 cites W2952658308 @default.
- W4386465377 cites W2984763033 @default.
- W4386465377 cites W2989929077 @default.
- W4386465377 cites W3010532021 @default.
- W4386465377 cites W3156972901 @default.
- W4386465377 cites W3176008189 @default.
- W4386465377 cites W3182063950 @default.
- W4386465377 doi "https://doi.org/10.1038/s41419-023-06092-5" @default.
- W4386465377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37669935" @default.
- W4386465377 hasPublicationYear "2023" @default.
- W4386465377 type Work @default.
- W4386465377 citedByCount "0" @default.
- W4386465377 crossrefType "journal-article" @default.
- W4386465377 hasAuthorship W4386465377A5002458192 @default.
- W4386465377 hasAuthorship W4386465377A5016116228 @default.
- W4386465377 hasAuthorship W4386465377A5019752847 @default.
- W4386465377 hasAuthorship W4386465377A5026713312 @default.
- W4386465377 hasAuthorship W4386465377A5027873445 @default.
- W4386465377 hasAuthorship W4386465377A5029117570 @default.
- W4386465377 hasAuthorship W4386465377A5046908797 @default.
- W4386465377 hasAuthorship W4386465377A5048405476 @default.
- W4386465377 hasAuthorship W4386465377A5058429637 @default.
- W4386465377 hasAuthorship W4386465377A5061724140 @default.
- W4386465377 hasAuthorship W4386465377A5075683151 @default.
- W4386465377 hasAuthorship W4386465377A5082419716 @default.
- W4386465377 hasAuthorship W4386465377A5084989005 @default.
- W4386465377 hasAuthorship W4386465377A5086560872 @default.
- W4386465377 hasBestOaLocation W43864653771 @default.
- W4386465377 hasConcept C104317684 @default.
- W4386465377 hasConcept C119157956 @default.
- W4386465377 hasConcept C121608353 @default.
- W4386465377 hasConcept C126322002 @default.
- W4386465377 hasConcept C143998085 @default.
- W4386465377 hasConcept C185592680 @default.