Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386466929> ?p ?o ?g. }
- W4386466929 endingPage "20201" @default.
- W4386466929 startingPage "20196" @default.
- W4386466929 abstract "Hydroxylamine-derived reagents have enabled versatile nitrene transfer reactions for introducing nitrogen-containing functionalities in small-molecule catalysis, as well as biocatalysis. These reagents, however, result in a poor atom economy and stoichiometric organic waste. Activating hydroxylamine (NH2OH) for nitrene transfer offers a low-cost and sustainable route to amine synthesis, since water is the sole byproduct. Despite its presence in nature, hydroxylamine is not known to be used for enzymatic nitrogen incorporation in biosynthesis. Here, we report an engineered heme enzyme that can utilize hydroxylammonium chloride, an inexpensive commodity chemical, for nitrene transfer. Directed evolution of Pyrobaculum arsenaticum protoglobin generated efficient enzymes for benzylic C-H primary amination and styrene aminohydroxylation. Mechanistic studies supported a stepwise radical pathway involving rate-limiting hydrogen atom transfer. This unprecedented activity is a useful addition to the nitrene transferase repertoire and hints at possible future discovery of natural enzymes that use hydroxylamine for amination chemistry." @default.
- W4386466929 created "2023-09-07" @default.
- W4386466929 creator A5016234863 @default.
- W4386466929 creator A5023203307 @default.
- W4386466929 creator A5027945137 @default.
- W4386466929 creator A5060399773 @default.
- W4386466929 creator A5081226757 @default.
- W4386466929 creator A5086426097 @default.
- W4386466929 date "2023-09-06" @default.
- W4386466929 modified "2023-10-11" @default.
- W4386466929 title "Enzymatic Nitrogen Incorporation Using Hydroxylamine" @default.
- W4386466929 cites W1487814959 @default.
- W4386466929 cites W1976410590 @default.
- W4386466929 cites W1979259658 @default.
- W4386466929 cites W1981836681 @default.
- W4386466929 cites W1995612596 @default.
- W4386466929 cites W2008754081 @default.
- W4386466929 cites W2058849821 @default.
- W4386466929 cites W2062298804 @default.
- W4386466929 cites W2083744110 @default.
- W4386466929 cites W2093157324 @default.
- W4386466929 cites W2103385859 @default.
- W4386466929 cites W2109441358 @default.
- W4386466929 cites W2162652079 @default.
- W4386466929 cites W2340271397 @default.
- W4386466929 cites W2398693549 @default.
- W4386466929 cites W2550997175 @default.
- W4386466929 cites W2617140651 @default.
- W4386466929 cites W2734889802 @default.
- W4386466929 cites W2767044445 @default.
- W4386466929 cites W2769883184 @default.
- W4386466929 cites W2778341989 @default.
- W4386466929 cites W2786747858 @default.
- W4386466929 cites W2801390591 @default.
- W4386466929 cites W2808178331 @default.
- W4386466929 cites W2908452108 @default.
- W4386466929 cites W2979854900 @default.
- W4386466929 cites W3013064848 @default.
- W4386466929 cites W3025895458 @default.
- W4386466929 cites W3026121095 @default.
- W4386466929 cites W3093643402 @default.
- W4386466929 cites W3110060582 @default.
- W4386466929 cites W3133047276 @default.
- W4386466929 cites W3162699243 @default.
- W4386466929 cites W3164178662 @default.
- W4386466929 cites W3175171924 @default.
- W4386466929 cites W3200686549 @default.
- W4386466929 cites W3204357064 @default.
- W4386466929 cites W4200098981 @default.
- W4386466929 cites W4200219606 @default.
- W4386466929 cites W4210320504 @default.
- W4386466929 cites W4280544970 @default.
- W4386466929 cites W4292607405 @default.
- W4386466929 cites W4300981430 @default.
- W4386466929 cites W4311821622 @default.
- W4386466929 cites W4311929984 @default.
- W4386466929 cites W4316467671 @default.
- W4386466929 cites W4321792340 @default.
- W4386466929 doi "https://doi.org/10.1021/jacs.3c08053" @default.
- W4386466929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37671894" @default.
- W4386466929 hasPublicationYear "2023" @default.
- W4386466929 type Work @default.
- W4386466929 citedByCount "0" @default.
- W4386466929 crossrefType "journal-article" @default.
- W4386466929 hasAuthorship W4386466929A5016234863 @default.
- W4386466929 hasAuthorship W4386466929A5023203307 @default.
- W4386466929 hasAuthorship W4386466929A5027945137 @default.
- W4386466929 hasAuthorship W4386466929A5060399773 @default.
- W4386466929 hasAuthorship W4386466929A5081226757 @default.
- W4386466929 hasAuthorship W4386466929A5086426097 @default.
- W4386466929 hasConcept C161790260 @default.
- W4386466929 hasConcept C178790620 @default.
- W4386466929 hasConcept C185592680 @default.
- W4386466929 hasConcept C191503008 @default.
- W4386466929 hasConcept C198503264 @default.
- W4386466929 hasConcept C21951064 @default.
- W4386466929 hasConcept C2775999725 @default.
- W4386466929 hasConcept C38489247 @default.
- W4386466929 hasConcept C65024703 @default.
- W4386466929 hasConceptScore W4386466929C161790260 @default.
- W4386466929 hasConceptScore W4386466929C178790620 @default.
- W4386466929 hasConceptScore W4386466929C185592680 @default.
- W4386466929 hasConceptScore W4386466929C191503008 @default.
- W4386466929 hasConceptScore W4386466929C198503264 @default.
- W4386466929 hasConceptScore W4386466929C21951064 @default.
- W4386466929 hasConceptScore W4386466929C2775999725 @default.
- W4386466929 hasConceptScore W4386466929C38489247 @default.
- W4386466929 hasConceptScore W4386466929C65024703 @default.
- W4386466929 hasFunder F4320312920 @default.
- W4386466929 hasFunder F4320332161 @default.
- W4386466929 hasFunder F4320332359 @default.
- W4386466929 hasIssue "37" @default.
- W4386466929 hasLocation W43864669291 @default.
- W4386466929 hasLocation W43864669292 @default.
- W4386466929 hasOpenAccess W4386466929 @default.
- W4386466929 hasPrimaryLocation W43864669291 @default.
- W4386466929 hasRelatedWork W1983515948 @default.
- W4386466929 hasRelatedWork W2003754630 @default.