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- W4386467207 abstract "Summary: Cancer is an age-related disease, with the majority of patients receiving their diagnosis after the age of 60 and most mortality from cancer occurring after this age. The tumor microenvironment changes drastically with age, which in turn affects cancer progression and treatment efficacy. Age-related changes to individual components of the microenvironment have received well-deserved attention over the past few decades, but the effects of aging at the interface of two or more microenvironmental components have been vastly understudied. In this perspective, we discuss the relationship between the aging extracellular matrix and the aging immune system, how they affect the tumor microenvironment, and how these multidisciplinary studies may open avenues for new therapeutics. Cancer is a disease of aging. With a rapidly aging population, we need to better understand the age-related changes that drive tumor progression, ranging from secreted changes to biophysical and immune changes." @default.
- W4386467207 created "2023-09-07" @default.
- W4386467207 creator A5085589424 @default.
- W4386467207 creator A5091108869 @default.
- W4386467207 date "2023-09-06" @default.
- W4386467207 modified "2023-10-14" @default.
- W4386467207 title "A Wrinkle in TIME: How Changes in the Aging ECM Drive the Remodeling of the Tumor Immune Microenvironment" @default.
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- W4386467207 doi "https://doi.org/10.1158/2159-8290.cd-23-0505" @default.
- W4386467207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37671471" @default.
- W4386467207 hasPublicationYear "2023" @default.
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