Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386467575> ?p ?o ?g. }
- W4386467575 abstract "ABSTRACT Maternal-to-fetal transmission of respiratory syncytial virus (RSV) has been shown to occur but whether late prenatal exposure to RSV season influences offspring postnatal RSV-lower respiratory illness (LRI) risk in early life or RSV immune status at birth is unclear. In this study, the duration of third trimester RSV season exposure was determined for 1,094 newborns of the Tucson Children’s Respiratory Study (TCRS) and found to show an inverse relation to risk for first RSV-LRI in the first year. Cord blood anti-RSV antibody is related to third trimester RSV season exposure but not to first year RSV-LRI risk. In a separate birth cohort (the Infant Immune Study), supernatants from cord blood mononuclear cells stimulated with the recall antigen, UV-inactivated RSV, were assayed for IFN-γ and IL-4. The frequency of detectable IFN-γ (but not IL-4) was increased for those with at least 2 mo of third trimester RSV season exposure, suggestive of a fetal immune response to RSV. IMPORTANCE Our study found that duration of third trimester exposure to RSV season related inversely to subsequent risk of postnatal RSV-LRI in the first year, thus implicating this exposure as an important factor in reducing risk of postnatal RSV-LRIs, a risk reduction that appears to be independent of maternally transferred anti-RSV antibody level. The increase in frequency of detectable IFN-γ and not IL-4 in response to UV-inactivated RSV in cord blood immune cells for infants with greater third trimester exposure to RSV season is suggestive of a Type-1 immune response to RSV occurring in utero ." @default.
- W4386467575 created "2023-09-07" @default.
- W4386467575 creator A5008526963 @default.
- W4386467575 creator A5036637586 @default.
- W4386467575 creator A5042613825 @default.
- W4386467575 creator A5054940860 @default.
- W4386467575 creator A5056700648 @default.
- W4386467575 creator A5074977259 @default.
- W4386467575 creator A5084840996 @default.
- W4386467575 date "2023-09-28" @default.
- W4386467575 modified "2023-10-01" @default.
- W4386467575 title "Prenatal exposure to RSV season influences first-year risk of RSV lower respiratory illness and RSV-specific immune responses assessed at birth" @default.
- W4386467575 cites W1561060155 @default.
- W4386467575 cites W1929856540 @default.
- W4386467575 cites W1947556504 @default.
- W4386467575 cites W1951007341 @default.
- W4386467575 cites W1982817475 @default.
- W4386467575 cites W1991630568 @default.
- W4386467575 cites W2001017978 @default.
- W4386467575 cites W2004927942 @default.
- W4386467575 cites W2025391611 @default.
- W4386467575 cites W2043393188 @default.
- W4386467575 cites W2051721450 @default.
- W4386467575 cites W2094983978 @default.
- W4386467575 cites W2100877443 @default.
- W4386467575 cites W2101114010 @default.
- W4386467575 cites W2122187646 @default.
- W4386467575 cites W2145445974 @default.
- W4386467575 cites W2162794057 @default.
- W4386467575 cites W2166245578 @default.
- W4386467575 cites W2322654587 @default.
- W4386467575 cites W2331939246 @default.
- W4386467575 cites W2468800990 @default.
- W4386467575 cites W2610042854 @default.
- W4386467575 cites W2749134140 @default.
- W4386467575 cites W2757615417 @default.
- W4386467575 cites W2764098312 @default.
- W4386467575 cites W2792552406 @default.
- W4386467575 cites W2800578026 @default.
- W4386467575 cites W2889790259 @default.
- W4386467575 cites W2920794476 @default.
- W4386467575 cites W2970902124 @default.
- W4386467575 cites W3045880340 @default.
- W4386467575 cites W4221009636 @default.
- W4386467575 cites W4229454852 @default.
- W4386467575 cites W4254903140 @default.
- W4386467575 cites W4281385327 @default.
- W4386467575 doi "https://doi.org/10.1128/jvi.00767-23" @default.
- W4386467575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37671863" @default.
- W4386467575 hasPublicationYear "2023" @default.
- W4386467575 type Work @default.
- W4386467575 citedByCount "0" @default.
- W4386467575 crossrefType "journal-article" @default.
- W4386467575 hasAuthorship W4386467575A5008526963 @default.
- W4386467575 hasAuthorship W4386467575A5036637586 @default.
- W4386467575 hasAuthorship W4386467575A5042613825 @default.
- W4386467575 hasAuthorship W4386467575A5054940860 @default.
- W4386467575 hasAuthorship W4386467575A5056700648 @default.
- W4386467575 hasAuthorship W4386467575A5074977259 @default.
- W4386467575 hasAuthorship W4386467575A5084840996 @default.
- W4386467575 hasConcept C105702510 @default.
- W4386467575 hasConcept C112672928 @default.
- W4386467575 hasConcept C140793950 @default.
- W4386467575 hasConcept C159654299 @default.
- W4386467575 hasConcept C172680121 @default.
- W4386467575 hasConcept C203014093 @default.
- W4386467575 hasConcept C2778299150 @default.
- W4386467575 hasConcept C2779234561 @default.
- W4386467575 hasConcept C2780914630 @default.
- W4386467575 hasConcept C534529494 @default.
- W4386467575 hasConcept C54355233 @default.
- W4386467575 hasConcept C86803240 @default.
- W4386467575 hasConcept C8891405 @default.
- W4386467575 hasConceptScore W4386467575C105702510 @default.
- W4386467575 hasConceptScore W4386467575C112672928 @default.
- W4386467575 hasConceptScore W4386467575C140793950 @default.
- W4386467575 hasConceptScore W4386467575C159654299 @default.
- W4386467575 hasConceptScore W4386467575C172680121 @default.
- W4386467575 hasConceptScore W4386467575C203014093 @default.
- W4386467575 hasConceptScore W4386467575C2778299150 @default.
- W4386467575 hasConceptScore W4386467575C2779234561 @default.
- W4386467575 hasConceptScore W4386467575C2780914630 @default.
- W4386467575 hasConceptScore W4386467575C534529494 @default.
- W4386467575 hasConceptScore W4386467575C54355233 @default.
- W4386467575 hasConceptScore W4386467575C86803240 @default.
- W4386467575 hasConceptScore W4386467575C8891405 @default.
- W4386467575 hasIssue "9" @default.
- W4386467575 hasLocation W43864675751 @default.
- W4386467575 hasLocation W43864675752 @default.
- W4386467575 hasOpenAccess W4386467575 @default.
- W4386467575 hasPrimaryLocation W43864675751 @default.
- W4386467575 hasRelatedWork W1541766870 @default.
- W4386467575 hasRelatedWork W1964501103 @default.
- W4386467575 hasRelatedWork W2006311894 @default.
- W4386467575 hasRelatedWork W2063472312 @default.
- W4386467575 hasRelatedWork W2068145071 @default.
- W4386467575 hasRelatedWork W2078337539 @default.
- W4386467575 hasRelatedWork W2103427042 @default.
- W4386467575 hasRelatedWork W2320470164 @default.
- W4386467575 hasRelatedWork W3176226870 @default.