FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386468030> ?p ?o ?g. }

• W4386468030 abstract "Abstract Background Radiation therapy is a primary treatment for hepatocellular carcinoma (HCC), but its effectiveness can be diminished by various factors. The over-expression of PD-L1 has been identified as a critical reason for radiotherapy resistance. Previous studies have demonstrated that nifuroxazide exerts antitumor activity by damaging the Stat3 pathway, but its efficacy against PD-L1 has remained unclear. In this study, we investigated whether nifuroxazide could enhance the efficacy of radiotherapy in HCC by reducing PD-L1 expression. Methods This study investigated the effects of Nifuroxazide on hepatocellular carcinoma using HepG2 cells and female C57BL/6 mice. HepG2 cells were irradiated and treated with different concentrations of Nifuroxazide, and various parameters were evaluated. Female C57BL/6 mice were divided into four groups and a hepatocellular carcinoma model was established. Each group received different treatments and observations were recorded. Spleens and tumor tissues were isolated from the mice and analyzed for tumor cell proliferation, apoptosis, and lymphocyte protein expression. T-cell subsets and the percentage of NK cells in the spleens were determined using flow cytometry. Results Our results showed that nifuroxazide significantly increased the sensitivity of tumor cells to radiation therapy by inhibiting cell proliferation and migration while increasing apoptosis in vitro . Additionally, nifuroxazide attenuated the up-regulation of PD-L1 expression induced by irradiation, which may be associated with increased degradation of PD-L1 through the ubiquitination-proteasome pathway. Furthermore, nifuroxazide greatly enhanced the efficacy of radiation therapy in H22-bearing mice by inhibiting tumor growth, improving survival, boosting the activation of T lymphocytes, and decelerating the ratios of Treg cells in spleens. Importantly, nifuroxazide limited the increased expression of PD-L1 in tumor tissues induced by radiation therapy. This study confirms, for the first time, that nifuroxazide can augment PD-L1 degradation to improve the efficacy of radiation therapy in HCC-bearing mice." @default.
• W4386468030 created "2023-09-07" @default.
• W4386468030 creator A5000108442 @default.
• W4386468030 creator A5000322479 @default.
• W4386468030 creator A5001438687 @default.
• W4386468030 creator A5011916760 @default.
• W4386468030 creator A5015247269 @default.
• W4386468030 creator A5017019889 @default.
• W4386468030 creator A5027299943 @default.
• W4386468030 creator A5032229723 @default.
• W4386468030 creator A5039962884 @default.
• W4386468030 creator A5041580796 @default.
• W4386468030 creator A5058014638 @default.
• W4386468030 creator A5060197272 @default.
• W4386468030 creator A5065798727 @default.
• W4386468030 creator A5072548035 @default.
• W4386468030 creator A5072876816 @default.
• W4386468030 creator A5075120323 @default.
• W4386468030 creator A5076924374 @default.
• W4386468030 creator A5089455540 @default.
• W4386468030 date "2023-09-06" @default.
• W4386468030 modified "2023-09-30" @default.
• W4386468030 title "Nifuroxazide enhances radiotherapy efficacy against hepatocellular carcinoma by upregulating PD-L1 degradation via the ubiquitin-proteasome pathway" @default.
• W4386468030 cites W2028279608 @default.
• W4386468030 cites W2068713081 @default.
• W4386468030 cites W2074285323 @default.
• W4386468030 cites W2560628113 @default.
• W4386468030 cites W2610224116 @default.
• W4386468030 cites W2790574591 @default.
• W4386468030 cites W2801517459 @default.
• W4386468030 cites W2806383117 @default.
• W4386468030 cites W2883594834 @default.
• W4386468030 cites W2911604706 @default.
• W4386468030 cites W2914403965 @default.
• W4386468030 cites W2915321625 @default.
• W4386468030 cites W2924762495 @default.
• W4386468030 cites W2943606118 @default.
• W4386468030 cites W2952477280 @default.
• W4386468030 cites W2971223564 @default.
• W4386468030 cites W2994559189 @default.
• W4386468030 cites W3011009916 @default.
• W4386468030 cites W3014516696 @default.
• W4386468030 cites W3016720267 @default.
• W4386468030 cites W3023037803 @default.
• W4386468030 cites W3076758593 @default.
• W4386468030 cites W3090720142 @default.
• W4386468030 cites W3119005666 @default.
• W4386468030 cites W3170739112 @default.
• W4386468030 cites W3172706779 @default.
• W4386468030 cites W3197402708 @default.
• W4386468030 cites W3202089767 @default.
• W4386468030 cites W4200558611 @default.
• W4386468030 cites W4205454439 @default.
• W4386468030 cites W4213108994 @default.
• W4386468030 cites W4243625103 @default.
• W4386468030 cites W4376848320 @default.
• W4386468030 doi "https://doi.org/10.1101/2023.09.03.556121" @default.
• W4386468030 hasPublicationYear "2023" @default.
• W4386468030 type Work @default.
• W4386468030 citedByCount "0" @default.
• W4386468030 crossrefType "posted-content" @default.
• W4386468030 hasAuthorship W4386468030A5000108442 @default.
• W4386468030 hasAuthorship W4386468030A5000322479 @default.
• W4386468030 hasAuthorship W4386468030A5001438687 @default.
• W4386468030 hasAuthorship W4386468030A5011916760 @default.
• W4386468030 hasAuthorship W4386468030A5015247269 @default.
• W4386468030 hasAuthorship W4386468030A5017019889 @default.
• W4386468030 hasAuthorship W4386468030A5027299943 @default.
• W4386468030 hasAuthorship W4386468030A5032229723 @default.
• W4386468030 hasAuthorship W4386468030A5039962884 @default.
• W4386468030 hasAuthorship W4386468030A5041580796 @default.
• W4386468030 hasAuthorship W4386468030A5058014638 @default.
• W4386468030 hasAuthorship W4386468030A5060197272 @default.
• W4386468030 hasAuthorship W4386468030A5065798727 @default.
• W4386468030 hasAuthorship W4386468030A5072548035 @default.
• W4386468030 hasAuthorship W4386468030A5072876816 @default.
• W4386468030 hasAuthorship W4386468030A5075120323 @default.
• W4386468030 hasAuthorship W4386468030A5076924374 @default.
• W4386468030 hasAuthorship W4386468030A5089455540 @default.
• W4386468030 hasBestOaLocation W43864680301 @default.
• W4386468030 hasConcept C185592680 @default.
• W4386468030 hasConcept C190283241 @default.
• W4386468030 hasConcept C203014093 @default.
• W4386468030 hasConcept C27740335 @default.
• W4386468030 hasConcept C2778019345 @default.
• W4386468030 hasConcept C502942594 @default.
• W4386468030 hasConcept C553184892 @default.
• W4386468030 hasConcept C55493867 @default.
• W4386468030 hasConcept C71924100 @default.
• W4386468030 hasConceptScore W4386468030C185592680 @default.
• W4386468030 hasConceptScore W4386468030C190283241 @default.
• W4386468030 hasConceptScore W4386468030C203014093 @default.
• W4386468030 hasConceptScore W4386468030C27740335 @default.
• W4386468030 hasConceptScore W4386468030C2778019345 @default.
• W4386468030 hasConceptScore W4386468030C502942594 @default.
• W4386468030 hasConceptScore W4386468030C553184892 @default.
• W4386468030 hasConceptScore W4386468030C55493867 @default.
• W4386468030 hasConceptScore W4386468030C71924100 @default.
• W4386468030 hasLocation W43864680301 @default.
• W4386468030 hasOpenAccess W4386468030 @default.

• next