Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386469199> ?p ?o ?g. }
- W4386469199 endingPage "13782" @default.
- W4386469199 startingPage "13768" @default.
- W4386469199 abstract "Although great progress has been made recently in targeted and immune-based therapies, additional treatments are needed for most melanoma patients due to acquired chemoresistance, recurrence, or metastasis. Elevated autophagy is required for the pathogenesis of melanoma to attenuate metabolic stress, protecting cancer cells from chemotherapeutics or radiation. Thus, intervention with autophagy is a promising strategy for melanoma treatment. Here, we examined a novel antimelanoma natural compound named kuwanon H (KuH), which significantly inhibited melanoma cell growth invitro/vivo. Mechanistically, KuH induced cytotoxic endoplasmic reticulum (ER) stress, which inhibited cell viability and induced apoptosis. Meanwhile, KuH-induced ER stress mediated autophagysome formation through the ATF4-DDIT3-TRIB3-AKT-MTOR axis. Importantly, KuH impaired autophagy flux, which contributed to the anticancer effects of KuH. Finally, our results showed that KuH enhanced the sensitivity of melanoma cells to cisplatin, both invitro and in vivo, by impairing autophagy degradation of reactive oxygen species and damaged mitochondria. Our findings indicate that KuH is a promising candidate anticancer natural product for melanoma therapy." @default.
- W4386469199 created "2023-09-07" @default.
- W4386469199 creator A5005093874 @default.
- W4386469199 creator A5026878092 @default.
- W4386469199 creator A5029555444 @default.
- W4386469199 creator A5036016529 @default.
- W4386469199 creator A5036859326 @default.
- W4386469199 creator A5038592450 @default.
- W4386469199 creator A5039802330 @default.
- W4386469199 creator A5053342330 @default.
- W4386469199 creator A5054020363 @default.
- W4386469199 creator A5070407653 @default.
- W4386469199 creator A5072740925 @default.
- W4386469199 creator A5091882153 @default.
- W4386469199 date "2023-09-06" @default.
- W4386469199 modified "2023-10-05" @default.
- W4386469199 title "Kuwanon H Inhibits Melanoma Growth through Cytotoxic Endoplasmic Reticulum Stress and Impaired Autophagy Flux" @default.
- W4386469199 cites W1674751464 @default.
- W4386469199 cites W1979783084 @default.
- W4386469199 cites W1984209860 @default.
- W4386469199 cites W2018652183 @default.
- W4386469199 cites W2034357604 @default.
- W4386469199 cites W2045122835 @default.
- W4386469199 cites W2050024462 @default.
- W4386469199 cites W2071285300 @default.
- W4386469199 cites W2088226047 @default.
- W4386469199 cites W2092820966 @default.
- W4386469199 cites W2099429776 @default.
- W4386469199 cites W2403462736 @default.
- W4386469199 cites W2406913770 @default.
- W4386469199 cites W2425010760 @default.
- W4386469199 cites W2509421821 @default.
- W4386469199 cites W2565453971 @default.
- W4386469199 cites W2565746848 @default.
- W4386469199 cites W2586097538 @default.
- W4386469199 cites W2600911889 @default.
- W4386469199 cites W2604219873 @default.
- W4386469199 cites W2745652592 @default.
- W4386469199 cites W2754676266 @default.
- W4386469199 cites W2797956345 @default.
- W4386469199 cites W2886636516 @default.
- W4386469199 cites W2898511356 @default.
- W4386469199 cites W2935622333 @default.
- W4386469199 cites W2937766145 @default.
- W4386469199 cites W2948634457 @default.
- W4386469199 cites W2952998155 @default.
- W4386469199 cites W2982979216 @default.
- W4386469199 cites W3003319481 @default.
- W4386469199 cites W3014753106 @default.
- W4386469199 cites W3024853202 @default.
- W4386469199 cites W3027954567 @default.
- W4386469199 cites W3038795195 @default.
- W4386469199 cites W3048367162 @default.
- W4386469199 cites W3097885939 @default.
- W4386469199 cites W3111963866 @default.
- W4386469199 cites W3119965837 @default.
- W4386469199 cites W3128442055 @default.
- W4386469199 cites W3130578067 @default.
- W4386469199 cites W3134838168 @default.
- W4386469199 cites W3148544959 @default.
- W4386469199 cites W3153216022 @default.
- W4386469199 cites W3154040928 @default.
- W4386469199 cites W3171856141 @default.
- W4386469199 cites W3177918665 @default.
- W4386469199 cites W3211976951 @default.
- W4386469199 cites W4200168827 @default.
- W4386469199 cites W4200359101 @default.
- W4386469199 cites W4206487309 @default.
- W4386469199 cites W4210415452 @default.
- W4386469199 cites W4220904234 @default.
- W4386469199 cites W4225322441 @default.
- W4386469199 cites W4283762260 @default.
- W4386469199 cites W4295906390 @default.
- W4386469199 cites W4298632682 @default.
- W4386469199 cites W4306842036 @default.
- W4386469199 cites W4313574394 @default.
- W4386469199 cites W4321377096 @default.
- W4386469199 cites W4324344827 @default.
- W4386469199 cites W4361294985 @default.
- W4386469199 doi "https://doi.org/10.1021/acs.jafc.3c02257" @default.
- W4386469199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37672659" @default.
- W4386469199 hasPublicationYear "2023" @default.
- W4386469199 type Work @default.
- W4386469199 citedByCount "0" @default.
- W4386469199 crossrefType "journal-article" @default.
- W4386469199 hasAuthorship W4386469199A5005093874 @default.
- W4386469199 hasAuthorship W4386469199A5026878092 @default.
- W4386469199 hasAuthorship W4386469199A5029555444 @default.
- W4386469199 hasAuthorship W4386469199A5036016529 @default.
- W4386469199 hasAuthorship W4386469199A5036859326 @default.
- W4386469199 hasAuthorship W4386469199A5038592450 @default.
- W4386469199 hasAuthorship W4386469199A5039802330 @default.
- W4386469199 hasAuthorship W4386469199A5053342330 @default.
- W4386469199 hasAuthorship W4386469199A5054020363 @default.
- W4386469199 hasAuthorship W4386469199A5070407653 @default.
- W4386469199 hasAuthorship W4386469199A5072740925 @default.
- W4386469199 hasAuthorship W4386469199A5091882153 @default.
- W4386469199 hasConcept C139447449 @default.