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- W4386469434 abstract "Abstract Sonodynamic therapy (SDT) has emerged as a highly effective modality for the treatment of malignant tumors owing to its powerful penetration ability, noninvasiveness, site‐confined irradiation, and excellent therapeutic efficacy. However, the traditional SDT, which relies on oxygen availability, often fails to generate a satisfactory level of reactive oxygen species because of the widespread issue of hypoxia in the tumor microenvironment of solid tumors. To address this challenge, various approaches are developed to alleviate hypoxia and improve the efficiency of SDT. These strategies aim to either increase oxygen supply or prevent hypoxia exacerbation, thereby enhancing the effectiveness of SDT. In view of this, the current review provides an overview of these strategies and their underlying principles, focusing on the circulation of oxygen from consumption to external supply. The detailed research examples conducted using these strategies in combination with SDT are also discussed. Additionally, this review highlights the future prospects and challenges of the hypoxia‐alleviated SDT, along with the key considerations for future clinical applications. These considerations include the development of efficient oxygen delivery systems, the accurate methods for hypoxia detection, and the exploration of combination therapies to optimize SDT outcomes." @default.
- W4386469434 created "2023-09-07" @default.
- W4386469434 creator A5014679455 @default.
- W4386469434 creator A5035264971 @default.
- W4386469434 creator A5058025282 @default.
- W4386469434 creator A5058541580 @default.
- W4386469434 creator A5070542012 @default.
- W4386469434 creator A5078100813 @default.
- W4386469434 creator A5012866332 @default.
- W4386469434 date "2023-09-17" @default.
- W4386469434 modified "2023-10-14" @default.
- W4386469434 title "Strategies to Reverse Hypoxic Tumor Microenvironment for Enhanced Sonodynamic Therapy" @default.
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