Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386474249> ?p ?o ?g. }
- W4386474249 abstract "The synthesis of fatty acids from acetyl-coenzyme A (AcCoA) is deregulated in diverse pathologies, including cancer. Here, we report that fatty acid accumulation is negatively regulated by nucleoside diphosphate kinases 1 and 2 (NME1/2), housekeeping enzymes involved in nucleotide homeostasis that were recently found to bind CoA. We show that NME1 additionally binds AcCoA and that ligand recognition involves a unique binding mode dependent on the CoA/AcCoA 3' phosphate. We report that Nme2 knockout mice fed a high-fat diet (HFD) exhibit excessive triglyceride synthesis and liver steatosis. In liver cells, NME2 mediates a gene transcriptional response to HFD leading to the repression of fatty acid accumulation and activation of a protective gene expression program via targeted histone acetylation. Our findings implicate NME1/2 in the epigenetic regulation of a protective liver response to HFD and suggest a potential role in controlling AcCoA usage between the competing paths of histone acetylation and fatty acid synthesis." @default.
- W4386474249 created "2023-09-07" @default.
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- W4386474249 date "2023-09-08" @default.
- W4386474249 modified "2023-10-17" @default.
- W4386474249 title "Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet" @default.
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