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• W4386475103 abstract "<p><i>SSTR2</i> promoter methylation levels in GEP-NET patients (<b>A</b> and <b>B</b>) and three NET cell lines (<b>C</b>). <b>A,</b> An NIH cohort of 96 patients with GEP-NETs was analyzed on the basis of tumor grade and methylation level. Those patients with higher-grade tumors showed increased methylation levels at the CpG methylation sites of the SSTR2 promoter. Significant changes were observed in the methylation levels between grades 1 and 2 (<i>P</i> = 0.034), grades 2 and 3 (<i>P</i> = 0.044), and grades 1 and 3 (<i>P</i> = 0.000014). <b>B,</b> The GSE117852 dataset of 32 patients with PNETs was analyzed for gene expression and mean <i>SSTR2</i> promoter methylation levels, using the Spearman method to calculate the <i>R</i> and <i>P</i> value. <b>C,</b> Methylation levels and SSTR2 expression were measured before and after treatment with VPA and azacytidine (TRTM) in three NET cell lines (QGP-1, BON-1, GOT-1). The controls are untreated for comparison (CTRL). The <i>x</i>-axis represents the degree of methylation (0–1), adjusted graphically for optimal visual display. The most significant changes were observed at CpG island cg14232289 (<i>P</i> < 0.0001).</p>" @default.
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• W4386475103 date "2023-09-06" @default.
• W4386475103 modified "2023-10-16" @default.
• W4386475103 title "Figure 1 from Upregulation of Somatostatin Receptor Type 2 Improves ¹⁷⁷Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model" @default.
• W4386475103 doi "https://doi.org/10.1158/1535-7163.24089591.v1" @default.
• W4386475103 hasPublicationYear "2023" @default.
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