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- W4386475148 abstract "<p>MAPKi induce HRD phenotype and thereby act synthetic lethal in combination with PARPi. <b>A,</b> Immunofluorescence of A375 S cells that were treated with 5 μmol/L talazoparib (Tala.), 5 μmol/L vemurafenib (Vem.), or a combination of both inhibitors (Combi.) for 24 hours, or remained untreated (Ctr.). Green: pH2AX, blue: DAPI. 40X magnification was used. Number of pH2AX foci per cell was counted and one-way ANOVA was performed to analyze the differences between the groups. <b>B,</b> Comet Assay was performed using A375 S cells that were treated with either 15 μmol/L talazoparib (Tala.), 5 μmol/L vemurafenib (Vem.), a combination of both drugs (Combi.) for 24 hours or remained untreated (Ctr.). Green: DNA. 10X magnification was used. <b>C,</b> RNA expression of MAPKi sensitive (S), vemurafenib resistant (R), or vemurafenib and trametinib double-resistant (RR) A375 cells after the treatment with 5 μmol/L vemurafenib (Vem.), 10 nmol/L trametinib (Trame.), or 5 μmol/L LY3009120 (LY.) for 24 hours. The relative gene expression of the treated cells compared with the control group is shown.</p>" @default.
- W4386475148 created "2023-09-07" @default.
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- W4386475148 date "2023-09-06" @default.
- W4386475148 modified "2023-09-27" @default.
- W4386475148 title "FIGURE 5 from PARP Inhibitors Effectively Reduce MAPK Inhibitor Resistant Melanoma Cell Growth and Synergize with MAPK Inhibitors through a Synthetic Lethal Interaction <i>In Vitro</i> and <i>In Vivo</i>" @default.
- W4386475148 doi "https://doi.org/10.1158/2767-9764.24089894" @default.
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