Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386475584> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4386475584 abstract "Abstract Background Baicalin has been shown to promote spatial learning and neural regeneration, which might increase the differentiation of neural stem cells in Alzheimer’s disease (AD) rat models. We aimed to study the role of baicalin on neuronal pentraxin-1 (NPTX-1), neuronal pentraxin-2 (NPTX-2), and C-reactive protein (CRP) in AD model rats. Methods The 30 male Sprague Dawley rats were divided into three groups: the control group, the AD model group, and the AD + baicalin group. Then, the Morris water maze was used to verify the effect of baicalin on the memory and spatial learning of rats. Immunohistochemistry and immunofluorescence were used to observe the expression of NPTX-1, NPTX-2, and CRP in brain tissue. Results Compared with the AD model group, the AD rats treated with baicalin spent significantly less time finding escape latencies ( P = 0.008) and had longer cross-platform times in the target quadrant ( P = 0.015). In addition, the AD + baicalin group had significantly higher numbers of hippocampal neurons compared with the AD model group ( P < 0.05). Baicalin also obviously decreased the apoptosis of neurons. Moreover, compared with the AD model group, the NPTX-1 and CRP expression in the AD + baicalin group was significantly reduced ( P = 0.000) while the expression of NPTX-2 in the brain tissue of AD rats was significantly increased ( P = 0.000). Conclusions Baicalin can play a therapeutic role by downregulating NPTX-1, upregulating NPTX-2, and downregulating CPR in AD model rats." @default.
- W4386475584 created "2023-09-07" @default.
- W4386475584 creator A5002032971 @default.
- W4386475584 creator A5005611137 @default.
- W4386475584 creator A5058701158 @default.
- W4386475584 creator A5083969121 @default.
- W4386475584 creator A5084320586 @default.
- W4386475584 date "2023-01-01" @default.
- W4386475584 modified "2023-09-26" @default.
- W4386475584 title "An interventional study of baicalin on neuronal pentraxin-1, neuronal pentraxin-2, and C-reactive protein in Alzheimer’s disease rat model" @default.
- W4386475584 cites W1964065265 @default.
- W4386475584 cites W1970567538 @default.
- W4386475584 cites W1971053086 @default.
- W4386475584 cites W2000908311 @default.
- W4386475584 cites W2003841076 @default.
- W4386475584 cites W2012801870 @default.
- W4386475584 cites W2025894278 @default.
- W4386475584 cites W2055190268 @default.
- W4386475584 cites W2065281821 @default.
- W4386475584 cites W2078165545 @default.
- W4386475584 cites W2082429191 @default.
- W4386475584 cites W2084060787 @default.
- W4386475584 cites W2094640306 @default.
- W4386475584 cites W2130945157 @default.
- W4386475584 cites W2136199683 @default.
- W4386475584 cites W2168334242 @default.
- W4386475584 cites W2169473035 @default.
- W4386475584 cites W2506432941 @default.
- W4386475584 cites W2562584466 @default.
- W4386475584 cites W2591323097 @default.
- W4386475584 cites W2761517608 @default.
- W4386475584 cites W2789287723 @default.
- W4386475584 cites W2791391987 @default.
- W4386475584 cites W2792619661 @default.
- W4386475584 cites W2913751428 @default.
- W4386475584 cites W4206631174 @default.
- W4386475584 cites W4206774749 @default.
- W4386475584 cites W4223591189 @default.
- W4386475584 cites W4293771139 @default.
- W4386475584 cites W4296077746 @default.
- W4386475584 cites W4309507742 @default.
- W4386475584 cites W4323035633 @default.
- W4386475584 cites W4386065661 @default.
- W4386475584 doi "https://doi.org/10.1515/tnsci-2022-0298" @default.
- W4386475584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37719746" @default.
- W4386475584 hasPublicationYear "2023" @default.
- W4386475584 type Work @default.
- W4386475584 citedByCount "0" @default.
- W4386475584 crossrefType "journal-article" @default.
- W4386475584 hasAuthorship W4386475584A5002032971 @default.
- W4386475584 hasAuthorship W4386475584A5005611137 @default.
- W4386475584 hasAuthorship W4386475584A5058701158 @default.
- W4386475584 hasAuthorship W4386475584A5083969121 @default.
- W4386475584 hasAuthorship W4386475584A5084320586 @default.
- W4386475584 hasBestOaLocation W43864755841 @default.
- W4386475584 hasConcept C126322002 @default.
- W4386475584 hasConcept C134018914 @default.
- W4386475584 hasConcept C148762608 @default.
- W4386475584 hasConcept C179998833 @default.
- W4386475584 hasConcept C185592680 @default.
- W4386475584 hasConcept C204232928 @default.
- W4386475584 hasConcept C2780113650 @default.
- W4386475584 hasConcept C2781161787 @default.
- W4386475584 hasConcept C43617362 @default.
- W4386475584 hasConcept C44752575 @default.
- W4386475584 hasConcept C71924100 @default.
- W4386475584 hasConcept C98274493 @default.
- W4386475584 hasConceptScore W4386475584C126322002 @default.
- W4386475584 hasConceptScore W4386475584C134018914 @default.
- W4386475584 hasConceptScore W4386475584C148762608 @default.
- W4386475584 hasConceptScore W4386475584C179998833 @default.
- W4386475584 hasConceptScore W4386475584C185592680 @default.
- W4386475584 hasConceptScore W4386475584C204232928 @default.
- W4386475584 hasConceptScore W4386475584C2780113650 @default.
- W4386475584 hasConceptScore W4386475584C2781161787 @default.
- W4386475584 hasConceptScore W4386475584C43617362 @default.
- W4386475584 hasConceptScore W4386475584C44752575 @default.
- W4386475584 hasConceptScore W4386475584C71924100 @default.
- W4386475584 hasConceptScore W4386475584C98274493 @default.
- W4386475584 hasIssue "1" @default.
- W4386475584 hasLocation W43864755841 @default.
- W4386475584 hasLocation W43864755842 @default.
- W4386475584 hasOpenAccess W4386475584 @default.
- W4386475584 hasPrimaryLocation W43864755841 @default.
- W4386475584 hasRelatedWork W1964065265 @default.
- W4386475584 hasRelatedWork W1984501765 @default.
- W4386475584 hasRelatedWork W2000662683 @default.
- W4386475584 hasRelatedWork W2030152196 @default.
- W4386475584 hasRelatedWork W2039296833 @default.
- W4386475584 hasRelatedWork W2354993017 @default.
- W4386475584 hasRelatedWork W2366980818 @default.
- W4386475584 hasRelatedWork W2397681982 @default.
- W4386475584 hasRelatedWork W2748952813 @default.
- W4386475584 hasRelatedWork W3031109344 @default.
- W4386475584 hasVolume "14" @default.
- W4386475584 isParatext "false" @default.
- W4386475584 isRetracted "false" @default.
- W4386475584 workType "article" @default.