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• W4386475764 abstract "The fungus Nectria sp. MHHJ-3 was isolated from Illigera rhodantha. A molecular networking-guided the secondary metabolites investigation of Nectria sp. MHHJ-3 led to the isolation of ten metabolites (1-10), including two new naphthalenone derivatives, nectrianaphthalenones A (1) and B (2), and two new steroids, nectriasteroids A (3) and B (4). Their structures were elucidated by extensive spectroscopic analysis including the HRESIMS, 1D/2D NMR and electronic circular dichroism (ECD) spectra. A plausible biosynthetic pathway for 1-2 was proposed. Compounds 1 and 2 exhibited moderate acetylcholinesterase (AChE) inhibitory activities. Compounds 3 and 4 showed significant cytotoxic activity against selected tumor cells. Particularly, compound 3 exhibited the strongest activity against A549 cells with an IC50 value of 13.73 ± 0.03 μM, which was at the same grade with that of positive control cisplatin." @default.
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• W4386475764 date "2023-12-01" @default.
• W4386475764 modified "2023-09-27" @default.
• W4386475764 title "Guided isolation of secondary metabolites from Nectria sp. MHHJ-3 by molecular network strategy" @default.
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• W4386475764 doi "https://doi.org/10.1016/j.fitote.2023.105668" @default.
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