Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386475991> ?p ?o ?g. }
- W4386475991 endingPage "1141" @default.
- W4386475991 startingPage "1141" @default.
- W4386475991 abstract "The recognition of microbe and extracellular matrix (ECM) is a recurring theme in the humoral innate immune system. Fluid-phase molecules of innate immunity share regulatory roles in ECM. On the other hand, ECM elements have immunological functions. Innate immunity is evolutionary and functionally connected to hemostasis. Staphylococcus aureus (S. aureus) is a major cause of hospital-associated bloodstream infections and the most common cause of several life-threatening conditions such as endocarditis and sepsis through its ability to manipulate hemostasis. Biofilm-related infection and sepsis represent a medical need due to the lack of treatments and the high resistance to antibiotics. We designed a method combining imaging and microfluidics to dissect the role of elements of the ECM and hemostasis in triggering S. aureus biofilm by highlighting an essential role of fibrinogen (FG) in adhesion and formation. Furthermore, we ascertained an important role of the fluid-phase activation of fibrinolysis in inhibiting biofilm of S. aureus and facilitating an antibody-mediated response aimed at pathogen killing. The results define FG as an essential element of hemostasis in the S. aureus biofilm formation and a role of fibrinolysis in its inhibition, while promoting an antibody-mediated response. Understanding host molecular mechanisms influencing biofilm formation and degradation is instrumental for the development of new combined therapeutic approaches to prevent the risk of S. aureus biofilm-associated diseases." @default.
- W4386475991 created "2023-09-07" @default.
- W4386475991 creator A5013198517 @default.
- W4386475991 creator A5014018414 @default.
- W4386475991 creator A5020386511 @default.
- W4386475991 creator A5023148161 @default.
- W4386475991 creator A5040551472 @default.
- W4386475991 creator A5057186485 @default.
- W4386475991 creator A5057685639 @default.
- W4386475991 creator A5078160598 @default.
- W4386475991 creator A5080137334 @default.
- W4386475991 creator A5083182126 @default.
- W4386475991 creator A5086871102 @default.
- W4386475991 date "2023-09-06" @default.
- W4386475991 modified "2023-10-17" @default.
- W4386475991 title "A Multilayered Imaging and Microfluidics Approach for Evaluating the Effect of Fibrinolysis in Staphylococcus aureus Biofilm Formation" @default.
- W4386475991 cites W1531268983 @default.
- W4386475991 cites W1716237860 @default.
- W4386475991 cites W1886710441 @default.
- W4386475991 cites W1894776803 @default.
- W4386475991 cites W1899719674 @default.
- W4386475991 cites W1916719191 @default.
- W4386475991 cites W1964848005 @default.
- W4386475991 cites W1973311237 @default.
- W4386475991 cites W1976954262 @default.
- W4386475991 cites W1986176487 @default.
- W4386475991 cites W1986438546 @default.
- W4386475991 cites W1998960362 @default.
- W4386475991 cites W2000531332 @default.
- W4386475991 cites W2027165635 @default.
- W4386475991 cites W2029655969 @default.
- W4386475991 cites W2029677015 @default.
- W4386475991 cites W2037541009 @default.
- W4386475991 cites W2039258127 @default.
- W4386475991 cites W2047623832 @default.
- W4386475991 cites W2048892639 @default.
- W4386475991 cites W2049527081 @default.
- W4386475991 cites W2053460725 @default.
- W4386475991 cites W2062182733 @default.
- W4386475991 cites W2064369146 @default.
- W4386475991 cites W2068041880 @default.
- W4386475991 cites W2072110323 @default.
- W4386475991 cites W2077930487 @default.
- W4386475991 cites W2089713734 @default.
- W4386475991 cites W2091748474 @default.
- W4386475991 cites W2092673460 @default.
- W4386475991 cites W2097708776 @default.
- W4386475991 cites W2119115625 @default.
- W4386475991 cites W2120224373 @default.
- W4386475991 cites W2124551895 @default.
- W4386475991 cites W2128088984 @default.
- W4386475991 cites W2141547848 @default.
- W4386475991 cites W2146364619 @default.
- W4386475991 cites W2154661271 @default.
- W4386475991 cites W2156382695 @default.
- W4386475991 cites W2158825633 @default.
- W4386475991 cites W2164561524 @default.
- W4386475991 cites W2167279371 @default.
- W4386475991 cites W2172965897 @default.
- W4386475991 cites W2214330682 @default.
- W4386475991 cites W2313619242 @default.
- W4386475991 cites W2330804969 @default.
- W4386475991 cites W2335557001 @default.
- W4386475991 cites W2417366306 @default.
- W4386475991 cites W2477957045 @default.
- W4386475991 cites W2522564570 @default.
- W4386475991 cites W2552154273 @default.
- W4386475991 cites W2553300030 @default.
- W4386475991 cites W2750857351 @default.
- W4386475991 cites W2770369272 @default.
- W4386475991 cites W2770879248 @default.
- W4386475991 cites W2775076624 @default.
- W4386475991 cites W2779317509 @default.
- W4386475991 cites W2808641599 @default.
- W4386475991 cites W2918970704 @default.
- W4386475991 cites W2936844729 @default.
- W4386475991 cites W2957901376 @default.
- W4386475991 cites W2975634117 @default.
- W4386475991 cites W3048414995 @default.
- W4386475991 cites W3099585008 @default.
- W4386475991 cites W3158869156 @default.
- W4386475991 cites W3184250239 @default.
- W4386475991 cites W4211163608 @default.
- W4386475991 cites W4220902062 @default.
- W4386475991 cites W4280600849 @default.
- W4386475991 cites W4281561438 @default.
- W4386475991 cites W4317659929 @default.
- W4386475991 cites W4318262992 @default.
- W4386475991 cites W4321018211 @default.
- W4386475991 cites W4322500741 @default.
- W4386475991 cites W4360584870 @default.
- W4386475991 cites W4377287694 @default.
- W4386475991 cites W4380550753 @default.
- W4386475991 doi "https://doi.org/10.3390/pathogens12091141" @default.
- W4386475991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37764949" @default.
- W4386475991 hasPublicationYear "2023" @default.
- W4386475991 type Work @default.
- W4386475991 citedByCount "0" @default.