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- W4386476168 abstract "Abstract Background: Survivors of sepsis hospitalization commonly experience functional impairment, which may limit return to work. We aimed to investigate return to work (RTW) of patients with sepsis and the associations between patient and clinical characteristics with RTW. Methods: Working-age patients (18 to 60 years) admitted to a Norwegian hospital with sepsis between 2010 and end of 2021 were identified using the Norwegian Patient Registry and linked to sick-leave data from the Norwegian National Social Security System Registry. The outcomes were time to RTW, trends in age-standardized proportions of RTW and probability of sustainable RTW (31 days of consecutive work). The trends were calculated for each admission year, reported as annual percentage change with 95% CI. Cox regression analysis, including crude and adjusted hazard risk (HRs), was used to explore the association between sustainable RTW and patient and clinical characteristics (e.g., COVID-19 vs non-COVID-19 sepsis, ward vs intensive care admission) with RTW. Results Among 35.839 hospitalizations for sepsis among patients aged 18 to 60 years during the study period, 12.260 (34.2%) were working prior to hospitalization and included in this study. The mean age was 43.7 years. At 6 months, 1 year, and 2 years post-discharge, 58.6%, 67.5%, and 63.4%, respectively, were working. The overall annual age-standardized RTW proportion at 6 months and 1 year remained stable throughout the study period, while the 2-year age-standardized RTW declined by 1.51% (95% CI, -2.22 to -0.79) per year, from 70.01% (95% CI, 67.21 to 74.80) in 2010 to 57.04% (95% CI, 53.81to 60.28) in 2019. Characteristics associated with sustainable RTW were younger age, fewer comorbidities, and fewer organ dysfunctions. The probability of sustainable RTW was higher in patients with COVID-19-related sepsis (HR 1.31; 95% CI 1.15 to 1.49) than in sepsis patients and lower in ICU-patients (HR 0.56; 95% CI 0.52 to 0.61) compared to ward-patients. Conclusion The decrease in RTW from 1 to 2 years and the temporal trend of declining RTW at 2 years needs attention, and further work facilitation efforts are required, especially in vulnerable groups that may need other interventions than today to achieve sustained RTW." @default.
- W4386476168 created "2023-09-07" @default.
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- W4386476168 date "2023-09-06" @default.
- W4386476168 modified "2023-09-27" @default.
- W4386476168 title "Return to work after hospitalization for sepsis; a nationwide, registry-based cohort study." @default.
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- W4386476168 doi "https://doi.org/10.21203/rs.3.rs-3328613/v1" @default.
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