FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386476688> ?p ?o ?g. }

• W4386476688 abstract "The treatment of cancer was revolutionized within the last two decades by utilizing the mechanism of the immune system against malignant tissue in so-called cancer immunotherapy. Two main developments boosted cancer immunotherapy: 1) the use of checkpoint inhibitors, which are characterized by a relatively high response rate mainly in solid tumors; however, at the cost of serious side effects, and 2) the use of chimeric antigen receptor (CAR)-T cells, which were shown to be very efficient in the treatment of hematologic malignancies, but failed to show high clinical effectiveness in solid tumors until now. In addition, active immunization against individual tumors is emerging, and the first products have reached clinical approval. These new treatment options are very cost-intensive and are not financially compensated by health insurance in many countries. Hence, strategies must be developed to make cancer immunotherapy affordable and to improve the cost-benefit ratio. In this review, we discuss the following strategies: 1) to leverage the antigenicity of cold tumors with affordable reagents, 2) to use microbiome-based products as markers or therapeutics, 3) to apply measures that make adoptive cell therapy (ACT) cheaper, e.g., the use of off-the-shelf products, 4) to use immunotherapies that offer cheaper platforms, such as RNA- or peptide-based vaccines and vaccines that use shared or common antigens instead of highly personal antigens, 5) to use a small set of predictive biomarkers instead of the sequence everything approach, and 6) to explore affordable immunohistochemistry markers that may direct individual therapies." @default.
• W4386476688 created "2023-09-07" @default.
• W4386476688 creator A5009930357 @default.
• W4386476688 creator A5011167937 @default.
• W4386476688 creator A5021478147 @default.
• W4386476688 creator A5045064568 @default.
• W4386476688 creator A5052441291 @default.
• W4386476688 creator A5053310678 @default.
• W4386476688 creator A5054793680 @default.
• W4386476688 creator A5064778812 @default.
• W4386476688 creator A5074296844 @default.
• W4386476688 creator A5075426741 @default.
• W4386476688 date "2023-09-06" @default.
• W4386476688 modified "2023-10-18" @default.
• W4386476688 title "The future of affordable cancer immunotherapy" @default.
• W4386476688 cites W1504474376 @default.
• W4386476688 cites W1535243328 @default.
• W4386476688 cites W1678468169 @default.
• W4386476688 cites W1978878186 @default.
• W4386476688 cites W1980137951 @default.
• W4386476688 cites W1990515033 @default.
• W4386476688 cites W1995580450 @default.
• W4386476688 cites W2038399651 @default.
• W4386476688 cites W2039123767 @default.
• W4386476688 cites W2043612975 @default.
• W4386476688 cites W2049553585 @default.
• W4386476688 cites W2063682146 @default.
• W4386476688 cites W2065363863 @default.
• W4386476688 cites W2067354849 @default.
• W4386476688 cites W2076361525 @default.
• W4386476688 cites W2083601518 @default.
• W4386476688 cites W2094751832 @default.
• W4386476688 cites W2094945699 @default.
• W4386476688 cites W2095598060 @default.
• W4386476688 cites W2102927263 @default.
• W4386476688 cites W2104597364 @default.
• W4386476688 cites W2108410958 @default.
• W4386476688 cites W2115176597 @default.
• W4386476688 cites W2116556475 @default.
• W4386476688 cites W2133298966 @default.
• W4386476688 cites W2136100686 @default.
• W4386476688 cites W2146445916 @default.
• W4386476688 cites W2152061559 @default.
• W4386476688 cites W2160143217 @default.
• W4386476688 cites W2166662937 @default.
• W4386476688 cites W2167553852 @default.
• W4386476688 cites W2299181842 @default.
• W4386476688 cites W2463547628 @default.
• W4386476688 cites W2539418106 @default.
• W4386476688 cites W2548694234 @default.
• W4386476688 cites W2560367415 @default.
• W4386476688 cites W2749362214 @default.
• W4386476688 cites W2759239761 @default.
• W4386476688 cites W2761575992 @default.
• W4386476688 cites W2766903152 @default.
• W4386476688 cites W2768089870 @default.
• W4386476688 cites W2794160747 @default.
• W4386476688 cites W2806895459 @default.
• W4386476688 cites W2809520091 @default.
• W4386476688 cites W2899145148 @default.
• W4386476688 cites W2900082702 @default.
• W4386476688 cites W2903484859 @default.
• W4386476688 cites W2907564726 @default.
• W4386476688 cites W2911604931 @default.
• W4386476688 cites W2912561170 @default.
• W4386476688 cites W2913415147 @default.
• W4386476688 cites W2914345456 @default.
• W4386476688 cites W2922288722 @default.
• W4386476688 cites W2946348245 @default.
• W4386476688 cites W2949459510 @default.
• W4386476688 cites W2968712798 @default.
• W4386476688 cites W2972356268 @default.
• W4386476688 cites W2977842151 @default.
• W4386476688 cites W2979785336 @default.
• W4386476688 cites W2987711192 @default.
• W4386476688 cites W3001956165 @default.
• W4386476688 cites W3004611567 @default.
• W4386476688 cites W3016048052 @default.
• W4386476688 cites W3016607029 @default.
• W4386476688 cites W3028940790 @default.
• W4386476688 cites W3031508706 @default.
• W4386476688 cites W3034367669 @default.
• W4386476688 cites W3037672888 @default.
• W4386476688 cites W3046115489 @default.
• W4386476688 cites W3091061098 @default.
• W4386476688 cites W3111836013 @default.
• W4386476688 cites W3113029153 @default.
• W4386476688 cites W3120457009 @default.
• W4386476688 cites W3126208996 @default.
• W4386476688 cites W3132255011 @default.
• W4386476688 cites W3176618876 @default.
• W4386476688 cites W3180780036 @default.
• W4386476688 cites W3202901824 @default.
• W4386476688 cites W3211423761 @default.
• W4386476688 cites W3213541617 @default.
• W4386476688 cites W3217808407 @default.
• W4386476688 cites W35202944 @default.
• W4386476688 cites W4206153591 @default.
• W4386476688 cites W4206610428 @default.
• W4386476688 cites W4210450192 @default.

• next