Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386477071> ?p ?o ?g. }
- W4386477071 endingPage "122524" @default.
- W4386477071 startingPage "122524" @default.
- W4386477071 abstract "Chronic kidney disease of unknown etiology (CKDu) is an endemic disease in the dry zone of farming communities, Sri Lanka. The drinking water in a CKDu prevalent area contains a high concentration of F-, hardness and other environmental pollutants, including heavy metals and microcystin, which are considered possible etiology of CKDu in these areas. Here, multi-omics data with host transcriptome, metabolome and gut microbiomes were obtained using simulated local drinking water of Sri Lanka after their exposure to adult zebrafish. Based on an integrated multi-omics analysis in the context of host physiology in the kidney injury samples with different pathologic grades, two common pathways necroptosis and purine metabolism were identified as potentially important pathways that affect kidney injury. The key metabolite acetyl adenylate in the purine metabolism pathway was significantly positively correlated with Comamonas (rho = 0.72) and significantly negatively correlated with Plesiomonas (rho = -0.58). This crucial metabolite and two key gut bacteria genera may not only be potential markers but also potential therapeutic targets in the uric acid metabolic pathway, which is an important factor in the pathogenesis of acute kidney injury (AKI) in general, as well as of chronic kidney disease (CKD). Based on this, we revealed the urea metabolism pathway of kidney injury in zebrafish and provided a new avenue for the treatment of CKDu in Sri Lanka." @default.
- W4386477071 created "2023-09-07" @default.
- W4386477071 creator A5003147636 @default.
- W4386477071 creator A5015262950 @default.
- W4386477071 creator A5015273050 @default.
- W4386477071 creator A5022882052 @default.
- W4386477071 creator A5026492595 @default.
- W4386477071 creator A5065708432 @default.
- W4386477071 creator A5074731531 @default.
- W4386477071 date "2023-11-01" @default.
- W4386477071 modified "2023-09-30" @default.
- W4386477071 title "Multi-omics reveal mechanisms underlying chronic kidney disease of unknown etiology (CKDu) pathogenesis using zebrafish" @default.
- W4386477071 cites W1526255994 @default.
- W4386477071 cites W1698019464 @default.
- W4386477071 cites W1810028515 @default.
- W4386477071 cites W1966327575 @default.
- W4386477071 cites W1976569265 @default.
- W4386477071 cites W1987979328 @default.
- W4386477071 cites W1990484548 @default.
- W4386477071 cites W1997272729 @default.
- W4386477071 cites W1999574084 @default.
- W4386477071 cites W2003144438 @default.
- W4386477071 cites W2004632880 @default.
- W4386477071 cites W2005980936 @default.
- W4386477071 cites W2011815318 @default.
- W4386477071 cites W2015336570 @default.
- W4386477071 cites W2027215920 @default.
- W4386477071 cites W2030788558 @default.
- W4386477071 cites W2044887439 @default.
- W4386477071 cites W2048779286 @default.
- W4386477071 cites W2055980989 @default.
- W4386477071 cites W2066526094 @default.
- W4386477071 cites W2075290657 @default.
- W4386477071 cites W2103017472 @default.
- W4386477071 cites W2113977541 @default.
- W4386477071 cites W2121182823 @default.
- W4386477071 cites W2140000393 @default.
- W4386477071 cites W2150589499 @default.
- W4386477071 cites W2154877414 @default.
- W4386477071 cites W2159675211 @default.
- W4386477071 cites W2162243074 @default.
- W4386477071 cites W2164249826 @default.
- W4386477071 cites W2170642681 @default.
- W4386477071 cites W2179438025 @default.
- W4386477071 cites W2184254448 @default.
- W4386477071 cites W2242602245 @default.
- W4386477071 cites W2328831822 @default.
- W4386477071 cites W2345489509 @default.
- W4386477071 cites W2514509547 @default.
- W4386477071 cites W2559729100 @default.
- W4386477071 cites W2603028808 @default.
- W4386477071 cites W2806716578 @default.
- W4386477071 cites W2889531675 @default.
- W4386477071 cites W2896673688 @default.
- W4386477071 cites W2907308062 @default.
- W4386477071 cites W2909263595 @default.
- W4386477071 cites W2943272538 @default.
- W4386477071 cites W2946727664 @default.
- W4386477071 cites W2947238838 @default.
- W4386477071 cites W2950484163 @default.
- W4386477071 cites W2966001002 @default.
- W4386477071 cites W2972444770 @default.
- W4386477071 cites W2981562581 @default.
- W4386477071 cites W3010276916 @default.
- W4386477071 cites W3014903642 @default.
- W4386477071 cites W3095583226 @default.
- W4386477071 cites W4292730494 @default.
- W4386477071 cites W4379522096 @default.
- W4386477071 doi "https://doi.org/10.1016/j.envpol.2023.122524" @default.
- W4386477071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37683759" @default.
- W4386477071 hasPublicationYear "2023" @default.
- W4386477071 type Work @default.
- W4386477071 citedByCount "0" @default.
- W4386477071 crossrefType "journal-article" @default.
- W4386477071 hasAuthorship W4386477071A5003147636 @default.
- W4386477071 hasAuthorship W4386477071A5015262950 @default.
- W4386477071 hasAuthorship W4386477071A5015273050 @default.
- W4386477071 hasAuthorship W4386477071A5022882052 @default.
- W4386477071 hasAuthorship W4386477071A5026492595 @default.
- W4386477071 hasAuthorship W4386477071A5065708432 @default.
- W4386477071 hasAuthorship W4386477071A5074731531 @default.
- W4386477071 hasConcept C104317684 @default.
- W4386477071 hasConcept C126322002 @default.
- W4386477071 hasConcept C134018914 @default.
- W4386477071 hasConcept C135870905 @default.
- W4386477071 hasConcept C151730666 @default.
- W4386477071 hasConcept C203014093 @default.
- W4386477071 hasConcept C21565614 @default.
- W4386477071 hasConcept C2776878037 @default.
- W4386477071 hasConcept C2777477808 @default.
- W4386477071 hasConcept C2778653478 @default.
- W4386477071 hasConcept C2779343474 @default.
- W4386477071 hasConcept C2780472472 @default.
- W4386477071 hasConcept C2780942790 @default.
- W4386477071 hasConcept C55493867 @default.
- W4386477071 hasConcept C60644358 @default.
- W4386477071 hasConcept C71924100 @default.
- W4386477071 hasConcept C86803240 @default.