Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386477799> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W4386477799 abstract "Background: As the COVID-19 pandemic continues, efforts to better understand SARS-CoV-2 viral shedding and transmission in both unvaccinated and vaccinated populations remain critical to informing public health policies and vaccine development. The utility of using RT-PCR cycle threshold values (CT values) as a proxy for infectious viral titers from individuals infected with SARS-CoV-2 is yet to be fully understood. This retrospective observational cohort study compares quantitative infectious viral titers derived from a focus-forming viral titer assay with SARS-CoV-2 RT-PCR CT values in both unvaccinated and vaccinated individuals infected with the Delta strain.Methods: Nasopharyngeal swabs positive for SARS-CoV-2 by RT-PCR with a CT value < 27 collected from June 26th to October 17th of 2021 at the University of Vermont Medical Center Clinical Laboratory for which vaccination records were available were included. Partially vaccinated and individuals < 18 years of age were excluded. Infectious viral titers were determined using a micro-focus forming assay under BSL-3 containment.Results: 119 specimens from 22 unvaccinated and 97 vaccinated individuals met all inclusion criteria and had sufficient residual volume to undergo viral titering. A negative correlation between RT-PCR CT values and viral titers was observed in both unvaccinated and vaccinated groups. No difference in mean CT value or viral titer was detected between vaccinated and unvaccinated groups. Viral titers did not change as a function of time since vaccination.Conclusions: Our results add to the growing body of knowledge regarding the correlation of SARS-CoV-2 RNA levels and levels of infectious virus. At similar CT values, vaccination does not appear to impact an individual’s potential infectivity." @default.
- W4386477799 created "2023-09-07" @default.
- W4386477799 creator A5042484448 @default.
- W4386477799 date "2023-09-06" @default.
- W4386477799 modified "2023-09-27" @default.
- W4386477799 title "Editor response for version 1" @default.
- W4386477799 doi "https://doi.org/10.1099/acmi.0.000597.v1.5" @default.
- W4386477799 hasPublicationYear "2023" @default.
- W4386477799 type Work @default.
- W4386477799 citedByCount "0" @default.
- W4386477799 crossrefType "peer-review" @default.
- W4386477799 hasAuthorship W4386477799A5042484448 @default.
- W4386477799 hasBestOaLocation W43864777991 @default.
- W4386477799 hasConcept C116675565 @default.
- W4386477799 hasConcept C126322002 @default.
- W4386477799 hasConcept C12914427 @default.
- W4386477799 hasConcept C142462285 @default.
- W4386477799 hasConcept C159047783 @default.
- W4386477799 hasConcept C203014093 @default.
- W4386477799 hasConcept C22070199 @default.
- W4386477799 hasConcept C2522874641 @default.
- W4386477799 hasConcept C2779134260 @default.
- W4386477799 hasConcept C3008058167 @default.
- W4386477799 hasConcept C32611913 @default.
- W4386477799 hasConcept C524204448 @default.
- W4386477799 hasConcept C71924100 @default.
- W4386477799 hasConcept C89623803 @default.
- W4386477799 hasConceptScore W4386477799C116675565 @default.
- W4386477799 hasConceptScore W4386477799C126322002 @default.
- W4386477799 hasConceptScore W4386477799C12914427 @default.
- W4386477799 hasConceptScore W4386477799C142462285 @default.
- W4386477799 hasConceptScore W4386477799C159047783 @default.
- W4386477799 hasConceptScore W4386477799C203014093 @default.
- W4386477799 hasConceptScore W4386477799C22070199 @default.
- W4386477799 hasConceptScore W4386477799C2522874641 @default.
- W4386477799 hasConceptScore W4386477799C2779134260 @default.
- W4386477799 hasConceptScore W4386477799C3008058167 @default.
- W4386477799 hasConceptScore W4386477799C32611913 @default.
- W4386477799 hasConceptScore W4386477799C524204448 @default.
- W4386477799 hasConceptScore W4386477799C71924100 @default.
- W4386477799 hasConceptScore W4386477799C89623803 @default.
- W4386477799 hasLocation W43864777991 @default.
- W4386477799 hasOpenAccess W4386477799 @default.
- W4386477799 hasPrimaryLocation W43864777991 @default.
- W4386477799 hasRelatedWork W1982703806 @default.
- W4386477799 hasRelatedWork W2055960421 @default.
- W4386477799 hasRelatedWork W2056874204 @default.
- W4386477799 hasRelatedWork W2097778920 @default.
- W4386477799 hasRelatedWork W2888158018 @default.
- W4386477799 hasRelatedWork W2943058277 @default.
- W4386477799 hasRelatedWork W3207787146 @default.
- W4386477799 hasRelatedWork W4381942459 @default.
- W4386477799 hasRelatedWork W4384024323 @default.
- W4386477799 hasRelatedWork W2181940165 @default.
- W4386477799 isParatext "false" @default.
- W4386477799 isRetracted "false" @default.
- W4386477799 workType "peer-review" @default.