FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386477891> ?p ?o ?g. }

• W4386477891 abstract "Abstract Cryptides are a subfamily of bioactive peptides that exist in all living organisms. They are latently encrypted in their parent sequences and exhibit a wide range of biological activities when decrypted via in vivo or in vitro proteases. Cationic cryptides tend to be drawn to the negatively charged membranes of microbial and cancer cells, causing cell death through various mechanisms. This makes them promising candidates for alternative antimicrobial and anti-cancer therapies, as their mechanism of action is independent of gene mutations. In the current study, we employed an in silico approach to identify novel cationic cryptides with potential antimicrobial and anti-cancer activities in atypical and systematic strategy by reanalysis of a publicly available RNA-seq dataset of Pacific white shrimp ( Penaus vannamei ) in response to bacterial infection. Out of 12 cryptides identified, five were selected based on their net charges and potential for cell penetration. Following chemical synthesis, the cryptides were assayed in vitro to test for their biological activities. All five cryptides demonstrated a wide range of selective activity against the tested microbial and cancer cells, their anti-biofilm activities against mature biofilms, and their ability to interact with Gram-positive and negative bacterial membranes. Our research provides a framework for a comprehensive analysis of transcriptomes in various organisms to uncover novel bioactive cationic cryptides. This represents a significant step forward in combating the crisis of multi-drug-resistant microbial and cancer cells, as these cryptides neither induce mutations nor are influenced by mutations in the cells they target." @default.
• W4386477891 created "2023-09-07" @default.
• W4386477891 creator A5005333059 @default.
• W4386477891 creator A5021086121 @default.
• W4386477891 creator A5032555527 @default.
• W4386477891 creator A5059498160 @default.
• W4386477891 creator A5090957294 @default.
• W4386477891 date "2023-09-06" @default.
• W4386477891 modified "2023-09-28" @default.
• W4386477891 title "Novel cationic cryptides in Penaeus vannamei demonstrate antimicrobial and anti-cancer activities" @default.
• W4386477891 cites W1883683241 @default.
• W4386477891 cites W1970272505 @default.
• W4386477891 cites W1993447746 @default.
• W4386477891 cites W2003476217 @default.
• W4386477891 cites W2011657487 @default.
• W4386477891 cites W2014274241 @default.
• W4386477891 cites W2034595187 @default.
• W4386477891 cites W2058919317 @default.
• W4386477891 cites W2066875472 @default.
• W4386477891 cites W2078533938 @default.
• W4386477891 cites W2079273803 @default.
• W4386477891 cites W2083416546 @default.
• W4386477891 cites W2084845164 @default.
• W4386477891 cites W2088155937 @default.
• W4386477891 cites W2096431838 @default.
• W4386477891 cites W2096775086 @default.
• W4386477891 cites W2098300761 @default.
• W4386477891 cites W2118911320 @default.
• W4386477891 cites W2131271579 @default.
• W4386477891 cites W2153099927 @default.
• W4386477891 cites W2175270296 @default.
• W4386477891 cites W2315129821 @default.
• W4386477891 cites W2322844633 @default.
• W4386477891 cites W2329751725 @default.
• W4386477891 cites W2344689512 @default.
• W4386477891 cites W2406764016 @default.
• W4386477891 cites W2418269076 @default.
• W4386477891 cites W243303449 @default.
• W4386477891 cites W2591017015 @default.
• W4386477891 cites W2741494659 @default.
• W4386477891 cites W2769426045 @default.
• W4386477891 cites W2776278222 @default.
• W4386477891 cites W2791655454 @default.
• W4386477891 cites W2795309385 @default.
• W4386477891 cites W2803451318 @default.
• W4386477891 cites W2886119798 @default.
• W4386477891 cites W2902591970 @default.
• W4386477891 cites W2945701292 @default.
• W4386477891 cites W2948261638 @default.
• W4386477891 cites W2950408930 @default.
• W4386477891 cites W2969598413 @default.
• W4386477891 cites W2981285269 @default.
• W4386477891 cites W2997131071 @default.
• W4386477891 cites W3004034924 @default.
• W4386477891 cites W3017681812 @default.
• W4386477891 cites W3017832761 @default.
• W4386477891 cites W3041538267 @default.
• W4386477891 cites W3082296977 @default.
• W4386477891 cites W3083406432 @default.
• W4386477891 cites W3084418569 @default.
• W4386477891 cites W3121106137 @default.
• W4386477891 cites W3124281795 @default.
• W4386477891 cites W3127985967 @default.
• W4386477891 cites W3143638934 @default.
• W4386477891 cites W3153418506 @default.
• W4386477891 cites W3164122911 @default.
• W4386477891 cites W3177373379 @default.
• W4386477891 cites W4220766535 @default.
• W4386477891 cites W4223936888 @default.
• W4386477891 cites W4236150737 @default.
• W4386477891 cites W4238077010 @default.
• W4386477891 cites W4310599874 @default.
• W4386477891 cites W978854240 @default.
• W4386477891 doi "https://doi.org/10.1038/s41598-023-41581-9" @default.
• W4386477891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37673929" @default.
• W4386477891 hasPublicationYear "2023" @default.
• W4386477891 type Work @default.
• W4386477891 citedByCount "0" @default.
• W4386477891 crossrefType "journal-article" @default.
• W4386477891 hasAuthorship W4386477891A5005333059 @default.
• W4386477891 hasAuthorship W4386477891A5021086121 @default.
• W4386477891 hasAuthorship W4386477891A5032555527 @default.
• W4386477891 hasAuthorship W4386477891A5059498160 @default.
• W4386477891 hasAuthorship W4386477891A5090957294 @default.
• W4386477891 hasBestOaLocation W43864778911 @default.
• W4386477891 hasConcept C104317684 @default.
• W4386477891 hasConcept C121608353 @default.
• W4386477891 hasConcept C150194340 @default.
• W4386477891 hasConcept C162317418 @default.
• W4386477891 hasConcept C181199279 @default.
• W4386477891 hasConcept C182220744 @default.
• W4386477891 hasConcept C2775905019 @default.
• W4386477891 hasConcept C2776841996 @default.
• W4386477891 hasConcept C4937899 @default.
• W4386477891 hasConcept C505870484 @default.
• W4386477891 hasConcept C523546767 @default.
• W4386477891 hasConcept C54355233 @default.
• W4386477891 hasConcept C55493867 @default.
• W4386477891 hasConcept C58123911 @default.
• W4386477891 hasConcept C70721500 @default.

• next