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- W4386480707 abstract "Abstract Cancer remains a significant global health challenge, necessitating the exploration of novel and more precise therapeutic options beyond conventional treatments. In this regard, clustered regularly interspaced short palindromic repeats (CRISPR) systems have emerged as highly promising tools for clinical gene editing applications. The CRISPR family encompasses diverse CRISPR-associated (Cas) proteins that possess the ability to recognize specific target sequences. The initial CRISPR system consisted of the Cas9 protein and a single-guide RNA, which guide Cas9 to the desired target sequence, facilitating precise double-stranded cleavage. In addition to the traditional cis-cleavage activity, the more recently discovered Cas12 and Cas13 proteins exhibit trans-cleavage activity, which expands their potential applications in cancer diagnosis. In this review, we provide an overview of the functional characteristics of Cas9, Cas12, and Cas13. Furthermore, we highlight the latest advancements and applications of these CRISPR systems in cancer gene therapy and molecular diagnosis. We also emphasize the importance of understanding the strengths and limitations of each CRISPR system to maximize their clinical utility. By providing a comprehensive overview of the current state of CRISPR technology in cancer research, we aim to inspire further exploration and innovation in this rapidly evolving field. Graphical abstract" @default.
- W4386480707 created "2023-09-07" @default.
- W4386480707 creator A5000195931 @default.
- W4386480707 creator A5022867463 @default.
- W4386480707 creator A5031265522 @default.
- W4386480707 creator A5048738841 @default.
- W4386480707 creator A5068956785 @default.
- W4386480707 date "2023-09-06" @default.
- W4386480707 modified "2023-09-28" @default.
- W4386480707 title "CRISPR applications in cancer diagnosis and treatment" @default.
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