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- W4386483919 abstract "Abstract Background: Uveal melanoma (UM) is the most prevalent primary aggressive intraocular tumor, often exhibiting low immunogenicity. Therefore, identifying novel immune-related therapeutic targets for UM are crucial. Methods: The public bioinformatics database was used to comprehensively examine the link between MTMR14 expression, immune checkpoint blockade molecules, and the clinical data of patients with UM. Moreover, the potential predictive value of MTMR14 during immune checkpoint inhibitor therapy was investigated. Using gene expression databases, we examined the expression of MTMR14, as well as its genetic alterations, functional networks, and cancer immune infiltrates. Results: The expression of MTMR14 gradually declined as UM tumors progressed, and low MTMR14 expression was linked to poor overall survival (OS) and disease-free survival (DFS). Secondly, functional network analysis indicated a role for MTMR14 in regulating endoplasmic reticulum localization as well as kinase protein receptor activity in patients with UM. Notably, MTMR14 exhibited a close positive link toimmune-stimulatory molecules and a significant negative correlation with immune-suppressive molecules in patients with UM. Conclusions: These findings suggested that MTMR14 is useful in predicting the therapeutic effect of immune checkpoint inhibitor therapy due to its close correlation with immune cell infiltration as well as immune checkpoint molecule expression, thereby providing a solid framework for future investigation into the immunomodulatory function of MTMR14 in UM." @default.
- W4386483919 created "2023-09-07" @default.
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- W4386483919 date "2023-09-06" @default.
- W4386483919 modified "2023-09-27" @default.
- W4386483919 title "MTMR14 as a novel prognostic predictor and potential immunotherapy target in uveal melanoma" @default.
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- W4386483919 doi "https://doi.org/10.21203/rs.3.rs-3262955/v1" @default.
- W4386483919 hasPublicationYear "2023" @default.
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