Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386484346> ?p ?o ?g. }
- W4386484346 abstract "Subjective cognitive decline (SCD) may represent the earliest preclinical stage of Alzheimer's Disease (AD) for some older adults. However, the underlying neurobiology of SCD is not completely understood. Since executive function may be affected earlier than memory function in the progression of AD, we aimed to characterize SCD symptoms in terms of fMRI brain activity during the computerized digit-symbol substitution task (DSST), an executive function task. We also explored associations of DSST task performance with brain activation, SCD severity, and amyloid-ß (Aß) load.We analyzed data from 63 cognitively normal older individuals (mean age 73.6 ± 7.2) with varying degree of SCD symptoms. Participants completed a computerized version of DSST in the MR scanner and a Pittsburgh Compound-B (PiB)-PET scan to measure global cerebral Aß load.A voxel-wise analysis revealed that greater SCD severity was associated with lower dorsomedial thalamus activation. While task performance was not associated with brain activation nor Aß load, slower reaction time was associated with greater SCD severity.The observed lower dorsomedial thalamus activation may reflect declining familiarity-based working memory and the trans-thalamic executive function pathway in SCD. SCD symptoms may reflect altered neural function and subtle decline of executive function, while Aß load may have an indirect impact on neural function and performance. Self-perceived cognitive decline may serve as a psychological/subjective marker reflecting subtle brain changes." @default.
- W4386484346 created "2023-09-07" @default.
- W4386484346 creator A5002115637 @default.
- W4386484346 creator A5024995302 @default.
- W4386484346 creator A5027487816 @default.
- W4386484346 creator A5029440312 @default.
- W4386484346 creator A5036841670 @default.
- W4386484346 creator A5053071315 @default.
- W4386484346 creator A5056508217 @default.
- W4386484346 creator A5068192630 @default.
- W4386484346 creator A5078214450 @default.
- W4386484346 creator A5090741064 @default.
- W4386484346 date "2023-09-06" @default.
- W4386484346 modified "2023-09-27" @default.
- W4386484346 title "Low thalamic activity during a digit-symbol substitution task is associated with symptoms of subjective cognitive decline" @default.
- W4386484346 cites W1569100977 @default.
- W4386484346 cites W1782068133 @default.
- W4386484346 cites W1829710617 @default.
- W4386484346 cites W1974058328 @default.
- W4386484346 cites W1980111435 @default.
- W4386484346 cites W1983850663 @default.
- W4386484346 cites W1984624356 @default.
- W4386484346 cites W1985056536 @default.
- W4386484346 cites W1985968648 @default.
- W4386484346 cites W1990134753 @default.
- W4386484346 cites W1998292101 @default.
- W4386484346 cites W2000174278 @default.
- W4386484346 cites W2001277786 @default.
- W4386484346 cites W2012305168 @default.
- W4386484346 cites W2015167727 @default.
- W4386484346 cites W2017185691 @default.
- W4386484346 cites W2019930104 @default.
- W4386484346 cites W2025084014 @default.
- W4386484346 cites W2031516346 @default.
- W4386484346 cites W2031906533 @default.
- W4386484346 cites W2032986765 @default.
- W4386484346 cites W2034502763 @default.
- W4386484346 cites W2038244455 @default.
- W4386484346 cites W2041361760 @default.
- W4386484346 cites W2044349793 @default.
- W4386484346 cites W2046638602 @default.
- W4386484346 cites W2046741874 @default.
- W4386484346 cites W2048505725 @default.
- W4386484346 cites W2048662976 @default.
- W4386484346 cites W2049177120 @default.
- W4386484346 cites W2049199032 @default.
- W4386484346 cites W2050627935 @default.
- W4386484346 cites W2051809205 @default.
- W4386484346 cites W2062449052 @default.
- W4386484346 cites W2062630539 @default.
- W4386484346 cites W2066135058 @default.
- W4386484346 cites W2067442759 @default.
- W4386484346 cites W2072743331 @default.
- W4386484346 cites W2073061978 @default.
- W4386484346 cites W2075623307 @default.
- W4386484346 cites W2078184061 @default.
- W4386484346 cites W2083183563 @default.
- W4386484346 cites W2090579112 @default.
- W4386484346 cites W2106592748 @default.
- W4386484346 cites W2106869028 @default.
- W4386484346 cites W2108051154 @default.
- W4386484346 cites W2123081065 @default.
- W4386484346 cites W2127169747 @default.
- W4386484346 cites W2128136330 @default.
- W4386484346 cites W2131820071 @default.
- W4386484346 cites W2134305330 @default.
- W4386484346 cites W2135367355 @default.
- W4386484346 cites W2138790588 @default.
- W4386484346 cites W2144138616 @default.
- W4386484346 cites W2154521931 @default.
- W4386484346 cites W2170994321 @default.
- W4386484346 cites W2258646945 @default.
- W4386484346 cites W2316564488 @default.
- W4386484346 cites W2324056313 @default.
- W4386484346 cites W2412268812 @default.
- W4386484346 cites W2471096910 @default.
- W4386484346 cites W2522995391 @default.
- W4386484346 cites W2603760225 @default.
- W4386484346 cites W2745563016 @default.
- W4386484346 cites W2763250779 @default.
- W4386484346 cites W2763258862 @default.
- W4386484346 cites W2765201225 @default.
- W4386484346 cites W2775199901 @default.
- W4386484346 cites W2890269627 @default.
- W4386484346 cites W2911758536 @default.
- W4386484346 cites W2946832188 @default.
- W4386484346 cites W2963590605 @default.
- W4386484346 cites W2975971368 @default.
- W4386484346 cites W3011052031 @default.
- W4386484346 cites W3090998762 @default.
- W4386484346 cites W3147053507 @default.
- W4386484346 cites W3211262491 @default.
- W4386484346 cites W4211081781 @default.
- W4386484346 cites W4233768626 @default.
- W4386484346 doi "https://doi.org/10.3389/fpsyt.2023.1242822" @default.
- W4386484346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37743995" @default.
- W4386484346 hasPublicationYear "2023" @default.
- W4386484346 type Work @default.
- W4386484346 citedByCount "0" @default.
- W4386484346 crossrefType "journal-article" @default.