Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386484487> ?p ?o ?g. }
- W4386484487 endingPage "16545" @default.
- W4386484487 startingPage "16536" @default.
- W4386484487 abstract "Direct transplantation of cardiomyocytes (CMs) holds great potential to address the risk of arrhythmia and tumorigenesis associated with transplantation of pluripotent stem cell-derived CMs and the off-target issue related to in situ activation of cardiomyocyte proliferation using small molecules or genes for treating cardiovascular diseases (CVD). However, there remain several challenges associated with CM transplantation, such as limited proliferation capability, poor survival caused by immunosuppression from T lymphocytes, and a lack of information about CMs after in vivo administration. In this paper, we developed dual gene-loaded near-infrared AIEgen nanoplatforms with enhanced proliferation, relieved immunosuppression, and tracking capabilities for CM transplantation. First, we encapsulated a near-infrared emitting AIEgen (AIE810) with a customized amphiphilic polymer DSPE-PEI 2000 to afford AIE810@PEI nanoparticles (NPs). Then, we loaded the NPs with microRNA-302 for activating CM proliferation and siSOCS1 for attenuating immunosuppression from T lymphocytes by facilely mixing with nanoparticles to yield final nanoplatforms (i.e., AIE810@PEI-miR302-siSOCS1 NPFs). We demonstrated both in vitro and in vivo that CMs treated with the developed NPFs show significantly enhanced viability, proliferation, and in vivo survival as indicated by the MTT assay, Ki-67 staining, and in vivo subcutaneous CM tracking, respectively. The developed AIE810@PEI-miR302-siSOCS1 NPFs would be a powerful tool in advancing CM transplantation for treating CVD and optimizing the therapeutic route by in vivo CM tracking for accelerating clinical translation." @default.
- W4386484487 created "2023-09-07" @default.
- W4386484487 creator A5027632849 @default.
- W4386484487 creator A5029538452 @default.
- W4386484487 creator A5030041291 @default.
- W4386484487 creator A5036359199 @default.
- W4386484487 creator A5040370936 @default.
- W4386484487 creator A5042186161 @default.
- W4386484487 creator A5055919572 @default.
- W4386484487 creator A5064135755 @default.
- W4386484487 creator A5068392270 @default.
- W4386484487 creator A5072245810 @default.
- W4386484487 creator A5078674610 @default.
- W4386484487 date "2023-09-06" @default.
- W4386484487 modified "2023-09-29" @default.
- W4386484487 title "Dual Gene-Loaded Near-Infrared AIEgen Nanoplatforms with Promoted Proliferation, Relieved Immunosuppression, and Tracking Capabilities for Cardiomyocyte Transplantation" @default.
- W4386484487 cites W1965622240 @default.
- W4386484487 cites W2000643914 @default.
- W4386484487 cites W2015904405 @default.
- W4386484487 cites W2035435963 @default.
- W4386484487 cites W2039551908 @default.
- W4386484487 cites W2065667184 @default.
- W4386484487 cites W2088148644 @default.
- W4386484487 cites W2098861374 @default.
- W4386484487 cites W2102632736 @default.
- W4386484487 cites W2125299334 @default.
- W4386484487 cites W2140775408 @default.
- W4386484487 cites W2146803540 @default.
- W4386484487 cites W2177603935 @default.
- W4386484487 cites W2231393017 @default.
- W4386484487 cites W2320515052 @default.
- W4386484487 cites W2418551143 @default.
- W4386484487 cites W2507109864 @default.
- W4386484487 cites W2606416018 @default.
- W4386484487 cites W2607294132 @default.
- W4386484487 cites W2792523566 @default.
- W4386484487 cites W2793201398 @default.
- W4386484487 cites W2801567408 @default.
- W4386484487 cites W2808491607 @default.
- W4386484487 cites W2810485115 @default.
- W4386484487 cites W2884895909 @default.
- W4386484487 cites W2896852102 @default.
- W4386484487 cites W2899305057 @default.
- W4386484487 cites W2936738922 @default.
- W4386484487 cites W2953837354 @default.
- W4386484487 cites W2957215044 @default.
- W4386484487 cites W2990914781 @default.
- W4386484487 cites W3003671612 @default.
- W4386484487 cites W3004299218 @default.
- W4386484487 cites W3006887679 @default.
- W4386484487 cites W3015394846 @default.
- W4386484487 cites W3020675770 @default.
- W4386484487 cites W3046764254 @default.
- W4386484487 cites W3153441824 @default.
- W4386484487 cites W3212454452 @default.
- W4386484487 cites W4220711829 @default.
- W4386484487 cites W4220765453 @default.
- W4386484487 cites W4223569383 @default.
- W4386484487 doi "https://doi.org/10.1021/acsanm.3c02753" @default.
- W4386484487 hasPublicationYear "2023" @default.
- W4386484487 type Work @default.
- W4386484487 citedByCount "0" @default.
- W4386484487 crossrefType "journal-article" @default.
- W4386484487 hasAuthorship W4386484487A5027632849 @default.
- W4386484487 hasAuthorship W4386484487A5029538452 @default.
- W4386484487 hasAuthorship W4386484487A5030041291 @default.
- W4386484487 hasAuthorship W4386484487A5036359199 @default.
- W4386484487 hasAuthorship W4386484487A5040370936 @default.
- W4386484487 hasAuthorship W4386484487A5042186161 @default.
- W4386484487 hasAuthorship W4386484487A5055919572 @default.
- W4386484487 hasAuthorship W4386484487A5064135755 @default.
- W4386484487 hasAuthorship W4386484487A5068392270 @default.
- W4386484487 hasAuthorship W4386484487A5072245810 @default.
- W4386484487 hasAuthorship W4386484487A5078674610 @default.
- W4386484487 hasConcept C141071460 @default.
- W4386484487 hasConcept C150903083 @default.
- W4386484487 hasConcept C185592680 @default.
- W4386484487 hasConcept C202751555 @default.
- W4386484487 hasConcept C203014093 @default.
- W4386484487 hasConcept C207001950 @default.
- W4386484487 hasConcept C2780252810 @default.
- W4386484487 hasConcept C2911091166 @default.
- W4386484487 hasConcept C502942594 @default.
- W4386484487 hasConcept C55493867 @default.
- W4386484487 hasConcept C71924100 @default.
- W4386484487 hasConcept C86803240 @default.
- W4386484487 hasConceptScore W4386484487C141071460 @default.
- W4386484487 hasConceptScore W4386484487C150903083 @default.
- W4386484487 hasConceptScore W4386484487C185592680 @default.
- W4386484487 hasConceptScore W4386484487C202751555 @default.
- W4386484487 hasConceptScore W4386484487C203014093 @default.
- W4386484487 hasConceptScore W4386484487C207001950 @default.
- W4386484487 hasConceptScore W4386484487C2780252810 @default.
- W4386484487 hasConceptScore W4386484487C2911091166 @default.
- W4386484487 hasConceptScore W4386484487C502942594 @default.
- W4386484487 hasConceptScore W4386484487C55493867 @default.
- W4386484487 hasConceptScore W4386484487C71924100 @default.
- W4386484487 hasConceptScore W4386484487C86803240 @default.