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- W4386484712 endingPage "122076" @default.
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- W4386484712 abstract "The intracellular production of reactive oxygen species (ROS), composed of oxygen-reduced molecules, is important not only because of their lethal effects on microorganisms but also due to their potential inflammatory and metabolic regulation properties. The ROS pro-inflammatory properties are associated with the second signal to inflammasome activation, leading to cleaving pro-IL-1β and pro-IL18 before their secretion, as well as gasdermin-D, leading to pyroptosis. Some microorganisms can modulate NLRP3 and AIM-2 inflammasomes through ROS production: whilst Mycobacterium bovis, Mycobacterium kansasii, Francisella novicida, Brucella abortus, Listeria monocytogenes, Influenza virus, Syncytial respiratory virus, Porcine reproductive and respiratory syndrome virus, SARS-CoV, Mayaro virus, Leishmania amazonensis and Plasmodium sp. enhance inflammasome assembly, Hepatitis B virus, Mycobacterium marinum, Mycobacterium tuberculosis, Francisella tularensis and Leishmania sp. disrupt it. This process represents a recent cornerstone in our knowledge of the immunology of intracellular pathogens, which is reviewed in this mini-review." @default.
- W4386484712 created "2023-09-07" @default.
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- W4386484712 date "2023-10-01" @default.
- W4386484712 modified "2023-10-09" @default.
- W4386484712 title "Reactive oxygen species trigger inflammasome activation after intracellular microbial interaction" @default.
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- W4386484712 doi "https://doi.org/10.1016/j.lfs.2023.122076" @default.
- W4386484712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37683723" @default.
- W4386484712 hasPublicationYear "2023" @default.
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