FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386489714> ?p ?o ?g. }

• W4386489714 abstract "Arterial hypertension is a very heterogeneous disease, therefore the influence of environmental factors along with genetic factors leads to various options for the development and course of arterial hypertension. The aim of the study – to find out the effect of fixed combinations of antihypertensive drugs on the features of the clinical course of arterial hypertension in patients with gene polymorphism. We examined 86 patients. The patients were divided into 2 groups: group 1 consisted of 43 people who received a fixed combination of valsartan and amlodipine, group 2 included 43 patients who received a fixed combination of olmesartan and amlodipine. In patients of group 1, a significant decrease in average daily systolic blood pressure (SBP) in carriers of the AC genotype of the AGTR1 gene was established by 7.0% (p<0.01), as well as SBP and DBP (diastolic blood pressure) in carriers of the CC genotype by 11.3 % and 9.8% (p<0.01) respectively. Carriers of the TT, TC, and CC genotypes of the eNOS gene had a significant decrease in SBP by 7.8%, 8.3%, and 13.6% (p<0.01), respectively, and DBP was significantly different from the indicator before treatment in carriers of the CC genotype and decreased by 11.0% (p<0.02). In patients of group 2, a significant decrease in SBP in carriers of the AC genotype of the AGTR1 gene was established by 8.2 % and in DBP in carriers of the CC genotype by 11.2% (p<0.01). Carriers of TT, TC and CC genotypes of the eNOS gene had a probable decrease in the level of average daily SBP by 8.3%, 9.7% and 16.5%, respectively, compared to the level before treatment (p<0.01). In carriers of the CC genotype of the eNOS gene, BP decreased by 13.2% (p<0.01). It has been proven that the use of fixed combinations of valsartan with amlodipine and olmesartan with amlodipine in terms of its effect on the clinical course and the level of SBP and DBP in patients with arterial hypertension with a gene polymorphism is almost the same and is most pronounced in carriers of the CC genotype of the AGTR1 and eNOS genes. Keywords: valsartan, olmesartan, amlodipine." @default.
• W4386489714 created "2023-09-07" @default.
• W4386489714 creator A5019368660 @default.
• W4386489714 date "2021-12-31" @default.
• W4386489714 modified "2023-09-27" @default.
• W4386489714 title "Features of the clinical course of arterial hypertension in patients with gene polymorphism under the influence of antihypertensive medicines" @default.
• W4386489714 cites W1806941858 @default.
• W4386489714 cites W2108346443 @default.
• W4386489714 cites W2133416234 @default.
• W4386489714 cites W2316169010 @default.
• W4386489714 cites W2323430881 @default.
• W4386489714 cites W2596752773 @default.
• W4386489714 cites W2743705181 @default.
• W4386489714 cites W2767992133 @default.
• W4386489714 cites W2769003329 @default.
• W4386489714 cites W2898861888 @default.
• W4386489714 cites W2905827573 @default.
• W4386489714 cites W2990878859 @default.
• W4386489714 cites W3153746860 @default.
• W4386489714 cites W3194540869 @default.
• W4386489714 cites W4210545747 @default.
• W4386489714 cites W4382602778 @default.
• W4386489714 doi "https://doi.org/10.35339/msz.2021.90.4.hsh" @default.
• W4386489714 hasPublicationYear "2021" @default.
• W4386489714 type Work @default.
• W4386489714 citedByCount "0" @default.
• W4386489714 crossrefType "journal-article" @default.
• W4386489714 hasAuthorship W4386489714A5019368660 @default.
• W4386489714 hasBestOaLocation W43864897141 @default.
• W4386489714 hasConcept C104317684 @default.
• W4386489714 hasConcept C126322002 @default.
• W4386489714 hasConcept C135763542 @default.
• W4386489714 hasConcept C164705383 @default.
• W4386489714 hasConcept C2777387769 @default.
• W4386489714 hasConcept C2777622882 @default.
• W4386489714 hasConcept C2778326061 @default.
• W4386489714 hasConcept C2779646130 @default.
• W4386489714 hasConcept C2779766728 @default.
• W4386489714 hasConcept C519581460 @default.
• W4386489714 hasConcept C54355233 @default.
• W4386489714 hasConcept C71924100 @default.
• W4386489714 hasConcept C76252995 @default.
• W4386489714 hasConcept C84393581 @default.
• W4386489714 hasConcept C86803240 @default.
• W4386489714 hasConceptScore W4386489714C104317684 @default.
• W4386489714 hasConceptScore W4386489714C126322002 @default.
• W4386489714 hasConceptScore W4386489714C135763542 @default.
• W4386489714 hasConceptScore W4386489714C164705383 @default.
• W4386489714 hasConceptScore W4386489714C2777387769 @default.
• W4386489714 hasConceptScore W4386489714C2777622882 @default.
• W4386489714 hasConceptScore W4386489714C2778326061 @default.
• W4386489714 hasConceptScore W4386489714C2779646130 @default.
• W4386489714 hasConceptScore W4386489714C2779766728 @default.
• W4386489714 hasConceptScore W4386489714C519581460 @default.
• W4386489714 hasConceptScore W4386489714C54355233 @default.
• W4386489714 hasConceptScore W4386489714C71924100 @default.
• W4386489714 hasConceptScore W4386489714C76252995 @default.
• W4386489714 hasConceptScore W4386489714C84393581 @default.
• W4386489714 hasConceptScore W4386489714C86803240 @default.
• W4386489714 hasIssue "4" @default.
• W4386489714 hasLocation W43864897141 @default.
• W4386489714 hasOpenAccess W4386489714 @default.
• W4386489714 hasPrimaryLocation W43864897141 @default.
• W4386489714 hasRelatedWork W1998396678 @default.
• W4386489714 hasRelatedWork W2044178472 @default.
• W4386489714 hasRelatedWork W2052290674 @default.
• W4386489714 hasRelatedWork W2075317296 @default.
• W4386489714 hasRelatedWork W2168680225 @default.
• W4386489714 hasRelatedWork W2348529459 @default.
• W4386489714 hasRelatedWork W2350587434 @default.
• W4386489714 hasRelatedWork W2354086771 @default.
• W4386489714 hasRelatedWork W2805259746 @default.
• W4386489714 hasRelatedWork W3028927003 @default.
• W4386489714 hasVolume "90" @default.
• W4386489714 isParatext "false" @default.
• W4386489714 isRetracted "false" @default.
• W4386489714 workType "article" @default.