Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386490197> ?p ?o ?g. }
- W4386490197 endingPage "106677" @default.
- W4386490197 startingPage "106677" @default.
- W4386490197 abstract "Sexually mature female guppies (Poecilia reticulata) were exposed to environmentally relevant concentrations (20, 200, and 2000 ng/L) of 17β-trenbolone for four weeks. As evidenced by the increased caudal fin index and anal fins developing into gonopodium-like structures, exposed females displayed masculinized secondary sexual characteristics. Differential gene expression and subsequent pathway analysis of mRNA sequencing data revealed that the transcription of transforming growth factor beta/bone morphogenetic protein signaling pathway and Wnt signaling pathway were upregulated following 17β-trenbolone exposure. Enzyme-linked immunosorbent assays showed that the bone morphogenetic protein 7 protein content was elevated after 17β-trenbolone exposure. Finally, real-time PCR revealed that 17β-trenbolone treatment significantly increased androgen receptor mRNA levels, and molecular docking showed potent interaction between 17β-trenbolone and guppy androgen receptor. Furthermore, 17β-trenbolone-induced masculinization of caudal and anal fins in female guppies, concomitant to the upregulated expression of differentially expressed genes involved in the above-mentioned two signaling pathways, was significantly inhibited by flutamide (androgen receptor antagonist). These findings demonstrated that 17β-trenbolone masculinized fins of female guppies by activating the androgen receptor. This study revealed that 17β-trenbolone could upregulate signaling pathways related to fin growth and differentiation, and eventually cause caudal and anal fin masculinization in female guppies." @default.
- W4386490197 created "2023-09-07" @default.
- W4386490197 creator A5028552092 @default.
- W4386490197 creator A5048287456 @default.
- W4386490197 creator A5061720935 @default.
- W4386490197 creator A5064019234 @default.
- W4386490197 creator A5068451238 @default.
- W4386490197 creator A5085098106 @default.
- W4386490197 date "2023-10-01" @default.
- W4386490197 modified "2023-10-11" @default.
- W4386490197 title "17β-Trenbolone activates androgen receptor, upregulates transforming growth factor beta/bone morphogenetic protein and Wnt signaling pathways, and induces masculinization of caudal and anal fins in female guppies (Poecilia reticulata)" @default.
- W4386490197 cites W1662555992 @default.
- W4386490197 cites W1688913580 @default.
- W4386490197 cites W1900337607 @default.
- W4386490197 cites W1963598605 @default.
- W4386490197 cites W1973923387 @default.
- W4386490197 cites W1977089694 @default.
- W4386490197 cites W1978873013 @default.
- W4386490197 cites W1980223730 @default.
- W4386490197 cites W1985207433 @default.
- W4386490197 cites W1985538729 @default.
- W4386490197 cites W1997180258 @default.
- W4386490197 cites W1998320916 @default.
- W4386490197 cites W2005727548 @default.
- W4386490197 cites W2007164914 @default.
- W4386490197 cites W2033113579 @default.
- W4386490197 cites W2047640180 @default.
- W4386490197 cites W2050008248 @default.
- W4386490197 cites W2052001846 @default.
- W4386490197 cites W2052579845 @default.
- W4386490197 cites W2063434280 @default.
- W4386490197 cites W2067149182 @default.
- W4386490197 cites W2068009433 @default.
- W4386490197 cites W2072453541 @default.
- W4386490197 cites W2081366074 @default.
- W4386490197 cites W2083404673 @default.
- W4386490197 cites W2094022965 @default.
- W4386490197 cites W2108207596 @default.
- W4386490197 cites W2108433100 @default.
- W4386490197 cites W2113252442 @default.
- W4386490197 cites W2114765756 @default.
- W4386490197 cites W2118975893 @default.
- W4386490197 cites W2134545654 @default.
- W4386490197 cites W2135213305 @default.
- W4386490197 cites W2137222466 @default.
- W4386490197 cites W2139631347 @default.
- W4386490197 cites W2143239115 @default.
- W4386490197 cites W2147639568 @default.
- W4386490197 cites W2150899619 @default.
- W4386490197 cites W2153895746 @default.
- W4386490197 cites W2172270516 @default.
- W4386490197 cites W2271335135 @default.
- W4386490197 cites W2314372172 @default.
- W4386490197 cites W2343938601 @default.
- W4386490197 cites W2509178044 @default.
- W4386490197 cites W2522054472 @default.
- W4386490197 cites W2571772682 @default.
- W4386490197 cites W2751556508 @default.
- W4386490197 cites W2754451119 @default.
- W4386490197 cites W2766945138 @default.
- W4386490197 cites W2767671906 @default.
- W4386490197 cites W2789782126 @default.
- W4386490197 cites W2791562505 @default.
- W4386490197 cites W2801974053 @default.
- W4386490197 cites W2809925151 @default.
- W4386490197 cites W2896236201 @default.
- W4386490197 cites W2903109140 @default.
- W4386490197 cites W3010661276 @default.
- W4386490197 cites W3048002767 @default.
- W4386490197 cites W3103164917 @default.
- W4386490197 cites W3128857654 @default.
- W4386490197 cites W3179473554 @default.
- W4386490197 cites W3189058363 @default.
- W4386490197 cites W3194419397 @default.
- W4386490197 cites W4236708194 @default.
- W4386490197 doi "https://doi.org/10.1016/j.aquatox.2023.106677" @default.
- W4386490197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37677862" @default.
- W4386490197 hasPublicationYear "2023" @default.
- W4386490197 type Work @default.
- W4386490197 citedByCount "0" @default.
- W4386490197 crossrefType "journal-article" @default.
- W4386490197 hasAuthorship W4386490197A5028552092 @default.
- W4386490197 hasAuthorship W4386490197A5048287456 @default.
- W4386490197 hasAuthorship W4386490197A5061720935 @default.
- W4386490197 hasAuthorship W4386490197A5064019234 @default.
- W4386490197 hasAuthorship W4386490197A5068451238 @default.
- W4386490197 hasAuthorship W4386490197A5085098106 @default.
- W4386490197 hasConcept C104317684 @default.
- W4386490197 hasConcept C121608353 @default.
- W4386490197 hasConcept C126322002 @default.
- W4386490197 hasConcept C134018914 @default.
- W4386490197 hasConcept C137620995 @default.
- W4386490197 hasConcept C2777911890 @default.
- W4386490197 hasConcept C2780192828 @default.
- W4386490197 hasConcept C31507581 @default.
- W4386490197 hasConcept C54355233 @default.
- W4386490197 hasConcept C61367390 @default.
- W4386490197 hasConcept C62478195 @default.