FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386493713> ?p ?o ?g. }

• W4386493713 endingPage "9" @default.
• W4386493713 startingPage "1" @default.
• W4386493713 abstract "Background: Evidence on the risk of second primary cancer (SPC) following primary laryngeal squamous cell carcinoma (LSCC) is limited, especially in Europe.Methods: Patients diagnosed with primary LSCC from 1953-2018 were retrieved from the Finnish Cancer Registry. A total of 6241 LSCC patients were identified adding to 49,393 person-years (PY) of follow-up until the end of 2019. Only one patient emigrated and was lost to follow-up. Both standardized incidence ratios (SIR) and excess absolute risk (EAR) per 1000 person-years at risk (PYR) of second primary cancer (SPC) were calculated relative to the general population. Only non-laryngeal SPCs diagnosed six months after diagnosis of primary LSCC were included.Results: A SPC was diagnosed in 1244 LSCC patients (20% of all LSCC patients) over the 65-year period, predominantly in men (92%, n = 1170). Out of all SPCs, 34% were diagnosed within 0.5 to 5 years and 66% after 5 years from primary LSCC. Among male patients, the overall SIR for SPC at any location was 1.61 (95% CI: 1.52-1.71), corresponding to 9.49 excess SPCs per 1000 PYR (95% CI: 8.19-11). The corresponding SIR for women was 1.47 (95% CI: 1.15-1.84), yielding 4.82 excess SPCs per 1000 PYR (95% CI: 2.36-9.84). The risk remained significant even after 20 years of follow-up (SIR for all 1.73, 95% CI: 1.49-2.01 and EAR 16.8 per 1000 PY, 11.88-23.75). The risk for SPC was also significantly elevated in all age groups, except <40. The highest SIRs were for SPCs arising in the mouth/pharynx (SIR for all 3.08, 95% CI: 2.36-3.95 and EAR 0.80 per 1000 PY, 0.55-1.15) and lungs (3.02, 2.75-3.30 and 5.90 per 1000, 5.13-6.78).Conclusion: Patients with LSCC as primary cancer have a 60% excess risk for an SPC, especially for tobacco-associated cancers, remaining significantly elevated even decades after treatment.Although prior research on the risk of second primary cancer (SPC) among laryngeal squamous cell carcinoma (LSCC) patients has been conducted in other regions, the European perspective remains notably underrepresented. Moreover, studies on the subject focusing especially on LSCC are, even globally, only a few. The present study, with over 6000 LSCC patients followed-up over six decades, consists of the largest reported cohort of LSCC patients in Europe, and with the longest follow-up. Patients with LSCC as a primary cancer have a 60% excess risk for an SPC, which remains significantly elevated even 20 years after the diagnosis of the first primary cancer, especially for those with a tobacco/alcohol-related cancer. Healthcare professionals should be aware of the SPC risk among LSCC survivors who should be counseled about this phenomenon." @default.
• W4386493713 created "2023-09-07" @default.
• W4386493713 creator A5004302738 @default.
• W4386493713 creator A5007965763 @default.
• W4386493713 creator A5017412937 @default.
• W4386493713 creator A5038969994 @default.
• W4386493713 creator A5044863159 @default.
• W4386493713 creator A5064690189 @default.
• W4386493713 creator A5082823961 @default.
• W4386493713 date "2023-09-06" @default.
• W4386493713 modified "2023-10-16" @default.
• W4386493713 title "Significant risk of second primary cancer among laryngeal squamous cell carcinoma patients even after 20 years" @default.
• W4386493713 cites W1594464537 @default.
• W4386493713 cites W1969879877 @default.
• W4386493713 cites W1991949008 @default.
• W4386493713 cites W2016336976 @default.
• W4386493713 cites W2033696247 @default.
• W4386493713 cites W2034224744 @default.
• W4386493713 cites W2039435031 @default.
• W4386493713 cites W2058787857 @default.
• W4386493713 cites W2066511556 @default.
• W4386493713 cites W2077942885 @default.
• W4386493713 cites W2116389010 @default.
• W4386493713 cites W2118994154 @default.
• W4386493713 cites W2120044809 @default.
• W4386493713 cites W2122054636 @default.
• W4386493713 cites W2157290796 @default.
• W4386493713 cites W2291078124 @default.
• W4386493713 cites W2552678540 @default.
• W4386493713 cites W2598151303 @default.
• W4386493713 cites W2975274775 @default.
• W4386493713 cites W2989850411 @default.
• W4386493713 cites W3010822594 @default.
• W4386493713 cites W3025849701 @default.
• W4386493713 cites W3087026701 @default.
• W4386493713 cites W3201753313 @default.
• W4386493713 cites W4282052909 @default.
• W4386493713 doi "https://doi.org/10.1080/0284186x.2023.2254482" @default.
• W4386493713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37672344" @default.
• W4386493713 hasPublicationYear "2023" @default.
• W4386493713 type Work @default.
• W4386493713 citedByCount "0" @default.
• W4386493713 crossrefType "journal-article" @default.
• W4386493713 hasAuthorship W4386493713A5004302738 @default.
• W4386493713 hasAuthorship W4386493713A5007965763 @default.
• W4386493713 hasAuthorship W4386493713A5017412937 @default.
• W4386493713 hasAuthorship W4386493713A5038969994 @default.
• W4386493713 hasAuthorship W4386493713A5044863159 @default.
• W4386493713 hasAuthorship W4386493713A5064690189 @default.
• W4386493713 hasAuthorship W4386493713A5082823961 @default.
• W4386493713 hasConcept C120195587 @default.
• W4386493713 hasConcept C120665830 @default.
• W4386493713 hasConcept C121332964 @default.
• W4386493713 hasConcept C121608353 @default.
• W4386493713 hasConcept C126322002 @default.
• W4386493713 hasConcept C141071460 @default.
• W4386493713 hasConcept C2777546739 @default.
• W4386493713 hasConcept C2778527826 @default.
• W4386493713 hasConcept C2908647359 @default.
• W4386493713 hasConcept C3019992690 @default.
• W4386493713 hasConcept C44249647 @default.
• W4386493713 hasConcept C61511704 @default.
• W4386493713 hasConcept C71924100 @default.
• W4386493713 hasConcept C82789193 @default.
• W4386493713 hasConcept C90924648 @default.
• W4386493713 hasConcept C99454951 @default.
• W4386493713 hasConceptScore W4386493713C120195587 @default.
• W4386493713 hasConceptScore W4386493713C120665830 @default.
• W4386493713 hasConceptScore W4386493713C121332964 @default.
• W4386493713 hasConceptScore W4386493713C121608353 @default.
• W4386493713 hasConceptScore W4386493713C126322002 @default.
• W4386493713 hasConceptScore W4386493713C141071460 @default.
• W4386493713 hasConceptScore W4386493713C2777546739 @default.
• W4386493713 hasConceptScore W4386493713C2778527826 @default.
• W4386493713 hasConceptScore W4386493713C2908647359 @default.
• W4386493713 hasConceptScore W4386493713C3019992690 @default.
• W4386493713 hasConceptScore W4386493713C44249647 @default.
• W4386493713 hasConceptScore W4386493713C61511704 @default.
• W4386493713 hasConceptScore W4386493713C71924100 @default.
• W4386493713 hasConceptScore W4386493713C82789193 @default.
• W4386493713 hasConceptScore W4386493713C90924648 @default.
• W4386493713 hasConceptScore W4386493713C99454951 @default.
• W4386493713 hasLocation W43864937131 @default.
• W4386493713 hasLocation W43864937132 @default.
• W4386493713 hasOpenAccess W4386493713 @default.
• W4386493713 hasPrimaryLocation W43864937131 @default.
• W4386493713 hasRelatedWork W1988454945 @default.
• W4386493713 hasRelatedWork W1993983059 @default.
• W4386493713 hasRelatedWork W2052024448 @default.
• W4386493713 hasRelatedWork W2108089761 @default.
• W4386493713 hasRelatedWork W2323028516 @default.
• W4386493713 hasRelatedWork W2373787968 @default.
• W4386493713 hasRelatedWork W2374149423 @default.
• W4386493713 hasRelatedWork W2586280594 @default.
• W4386493713 hasRelatedWork W3043892729 @default.
• W4386493713 hasRelatedWork W4250768597 @default.
• W4386493713 isParatext "false" @default.
• W4386493713 isRetracted "false" @default.

• next