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- W4386493982 abstract "Abstract Background During breastfeeding the macronutrient composition of breastmilk changes gradually from relatively low-fat (foremilk) to relatively high-fat (hindmilk), initially exposing the gastrointestinal tract to a relatively low fat concentration. In contrast, infant formulae (IF) are homogenous. Mild processing and addition of milk fat globule membrane (MFGM) may impact gastric emulsion instability, potentially impacting the phased release of nutrients as observed during breastfeeding. Objective To assess gastric emulsion stability, gastric emptying, and the postprandial plasma metabolome of an experimental minimally processed IF (EF) with an altered fat-globule interface and a control IF (CF). Methods Twenty healthy males participated in this double-blind randomized crossover trial. Gastric MRI scans and blood samples were obtained before and after consumption of 600 ml CF or EF over a 2-h period. Outcomes included gastric top layer formation, total gastric volume, and blood parameters (FFA, insulin, glucose, and NMR-metabolomics). Results EF showed an earlier onset (13.4 min, p=0.017), smaller maximum volume (49.0 ml, p= 0.033), and a shorter time to maximum top layer volume (13.9 min, p=0.022), but similar AUC (p=0.915) compared to CF. Total gastric volume did not show a treatment*time effect. Insulin concentrations were lower for EF. FFA and glucose did not differ. EF yielded higher serum concentrations of phospholipid-and cholesterol-related metabolites. Conclusion An EF displayed faster gastric creaming than a CF, thereby potentially better mimicking the behavior of breastmilk which leads to phased release of nutrients into the intestine. Overall physiological benefits of this difference in gastric behavior remain to be studied further in infants." @default.
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- W4386493982 date "2023-09-07" @default.
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- W4386493982 title "Intragastric behavior of an experimental infant formula may better mimic intragastric behavior of human milk as compared to a control formula" @default.
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- W4386493982 doi "https://doi.org/10.1101/2023.09.06.23295112" @default.
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