FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386494088> ?p ?o ?g. }

• W4386494088 abstract "The natural Fisetin and its derivatives have been shown to have effective bioactivity and strong pharmacological profile, which is continuously drawing the interest of therapeutic applications to the development of new biomolecules against Breast cancer and Monkeypox, and Marburg viral infection, while computational approaches and the study of their structure-activity relationship (SAR) are the most eloquent and reliable platform for performing their hypothetical profile renovation. So, the main perspective of this investigation is to evaluate dual function of Fisetin and its derivatives against both virus and cancerous target. First and foremost, the prediction of activity spectra for materials (PASS) valuation has provided preliminary data on the antiviral, antibacterial, antiparasitic, and anti-cancer possibilities of the mentioned compounds. According to the evidence, PASS predicted scores were shown to perform better in antineoplastic and antiviral than antibacterial, and antiparasitic efficiency; as evidenced by their higher PASS scores in antineoplastic and antiviral drug tests. Breast cancer, Monkeypox, and Marburg virus have been selected as targeted pathogens, and different in silico studies were conducted to determine the dual function of mention derivatives. The Lipinski five rules, on the other hand, has been subjected to extensive testing for drug-like characteristics. Molecular docking against Breast cancer, Monkeypox, and Marburg virus have been accomplished after confirmation of their bioactivity. The molecular docking evaluation against targeted disease displayed re-markable binding affinity and non-bonding engagement, with most of the results indicating that derivatives are more effective than the FDA approved standard antiviral, and antineoplastic drugs. Finally, the ADMET characteristics have been computed, and they indicate that the substance is suitable to use and did not have any chance to produce adverse effects on aquatic or non-aquatic environment, as well as having a highly soluble capacity in water medium, high G.I absorption rate, with outstanding bioavailability index. Therefore, these mentioned Fisetin derivatives could be suggested as potential medication against Breast cancer and newly reported Monkeypox, and Marburg virus, and may further proceed for laboratory experiment, synthesis, and clinical trials to evaluate their practical value." @default.
• W4386494088 created "2023-09-07" @default.
• W4386494088 creator A5016252197 @default.
• W4386494088 creator A5028901993 @default.
• W4386494088 creator A5030392171 @default.
• W4386494088 creator A5033449880 @default.
• W4386494088 creator A5038525959 @default.
• W4386494088 creator A5042194510 @default.
• W4386494088 creator A5043283243 @default.
• W4386494088 creator A5050884324 @default.
• W4386494088 creator A5065787550 @default.
• W4386494088 creator A5086715747 @default.
• W4386494088 date "2023-09-07" @default.
• W4386494088 modified "2023-09-27" @default.
• W4386494088 title "Design and development of new inhibitors against breast cancer, Monkeypox and Marburg virus by modification of natural Fisetin via in silico and SAR studies" @default.
• W4386494088 doi "https://doi.org/10.18388/abp.2020_6667" @default.
• W4386494088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37677069" @default.
• W4386494088 hasPublicationYear "2023" @default.
• W4386494088 type Work @default.
• W4386494088 citedByCount "0" @default.
• W4386494088 crossrefType "journal-article" @default.
• W4386494088 hasAuthorship W4386494088A5016252197 @default.
• W4386494088 hasAuthorship W4386494088A5028901993 @default.
• W4386494088 hasAuthorship W4386494088A5030392171 @default.
• W4386494088 hasAuthorship W4386494088A5033449880 @default.
• W4386494088 hasAuthorship W4386494088A5038525959 @default.
• W4386494088 hasAuthorship W4386494088A5042194510 @default.
• W4386494088 hasAuthorship W4386494088A5043283243 @default.
• W4386494088 hasAuthorship W4386494088A5050884324 @default.
• W4386494088 hasAuthorship W4386494088A5065787550 @default.
• W4386494088 hasAuthorship W4386494088A5086715747 @default.
• W4386494088 hasBestOaLocation W43864940881 @default.
• W4386494088 hasConcept C104317684 @default.
• W4386494088 hasConcept C112705442 @default.
• W4386494088 hasConcept C159047783 @default.
• W4386494088 hasConcept C22979827 @default.
• W4386494088 hasConcept C2775905019 @default.
• W4386494088 hasConcept C2777376040 @default.
• W4386494088 hasConcept C2778004101 @default.
• W4386494088 hasConcept C2778335254 @default.
• W4386494088 hasConcept C2779054382 @default.
• W4386494088 hasConcept C41847442 @default.
• W4386494088 hasConcept C55493867 @default.
• W4386494088 hasConcept C86803240 @default.
• W4386494088 hasConcept C98274493 @default.
• W4386494088 hasConceptScore W4386494088C104317684 @default.
• W4386494088 hasConceptScore W4386494088C112705442 @default.
• W4386494088 hasConceptScore W4386494088C159047783 @default.
• W4386494088 hasConceptScore W4386494088C22979827 @default.
• W4386494088 hasConceptScore W4386494088C2775905019 @default.
• W4386494088 hasConceptScore W4386494088C2777376040 @default.
• W4386494088 hasConceptScore W4386494088C2778004101 @default.
• W4386494088 hasConceptScore W4386494088C2778335254 @default.
• W4386494088 hasConceptScore W4386494088C2779054382 @default.
• W4386494088 hasConceptScore W4386494088C41847442 @default.
• W4386494088 hasConceptScore W4386494088C55493867 @default.
• W4386494088 hasConceptScore W4386494088C86803240 @default.
• W4386494088 hasConceptScore W4386494088C98274493 @default.
• W4386494088 hasLocation W43864940881 @default.
• W4386494088 hasLocation W43864940882 @default.
• W4386494088 hasOpenAccess W4386494088 @default.
• W4386494088 hasPrimaryLocation W43864940881 @default.
• W4386494088 hasRelatedWork W2051978736 @default.
• W4386494088 hasRelatedWork W2804603998 @default.
• W4386494088 hasRelatedWork W2898114801 @default.
• W4386494088 hasRelatedWork W2952562261 @default.
• W4386494088 hasRelatedWork W3003214739 @default.
• W4386494088 hasRelatedWork W3080387325 @default.
• W4386494088 hasRelatedWork W4313207771 @default.
• W4386494088 hasRelatedWork W4362648959 @default.
• W4386494088 hasRelatedWork W4384696194 @default.
• W4386494088 hasRelatedWork W2183715099 @default.
• W4386494088 isParatext "false" @default.
• W4386494088 isRetracted "false" @default.
• W4386494088 workType "article" @default.