Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386494648> ?p ?o ?g. }
- W4386494648 abstract "Regulatory T cells (Tregs) modulate tissue homeostatic processes and immune responses. Understanding tissue-Treg biology will contribute to developing precision-targeting treatment strategies. Here, we show that Tregs maintain the tolerogenic state of the testis and epididymis, where sperm are produced and mature. We found that Treg depletion induces severe autoimmune orchitis and epididymitis, manifested by an exacerbated immune cell infiltration [CD4 T cells, monocytes, and mononuclear phagocytes (MPs)] and the development of antisperm antibodies (ASA). In Treg-depleted mice, MPs increased projections toward the epididymal lumen as well as invading the lumen. ASA-bound sperm enhance sperm agglutination and might facilitate sperm phagocytosis. Tolerance breakdown impaired epididymal epithelial function and altered extracellular vesicle cargo, both of which play crucial roles in the acquisition of sperm fertilizing ability and subsequent embryo development. The affected mice had reduced sperm number and motility and severe fertility defects. Deciphering these immunoregulatory mechanisms may help to design new strategies to treat male infertility, as well as to identify potential targets for immunocontraception." @default.
- W4386494648 created "2023-09-07" @default.
- W4386494648 creator A5019884351 @default.
- W4386494648 creator A5027818081 @default.
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- W4386494648 creator A5041566748 @default.
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- W4386494648 creator A5087672907 @default.
- W4386494648 date "2023-09-07" @default.
- W4386494648 modified "2023-09-28" @default.
- W4386494648 title "Regulatory T cells play a crucial role in maintaining sperm tolerance and male fertility" @default.
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